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Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones
An efficient, three-component reaction of aldehydes and benzofuran-3-ones was developed. This process provides a new approach for the preparation of synthetically and biologically important spirobenzofuran-3-one derivatives with moderate-to-good yields under mild conditions. A switch of intramolecul...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503435/ https://www.ncbi.nlm.nih.gov/pubmed/36144686 http://dx.doi.org/10.3390/molecules27185952 |
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author | Wang, Zhanyong Yang, Ting Liu, Dongfang Chen, Rongxiang Wang, Nan Liu, Hong Li, Jiarong Wang, Kaikai Liu, Hongxin |
author_facet | Wang, Zhanyong Yang, Ting Liu, Dongfang Chen, Rongxiang Wang, Nan Liu, Hong Li, Jiarong Wang, Kaikai Liu, Hongxin |
author_sort | Wang, Zhanyong |
collection | PubMed |
description | An efficient, three-component reaction of aldehydes and benzofuran-3-ones was developed. This process provides a new approach for the preparation of synthetically and biologically important spirobenzofuran-3-one derivatives with moderate-to-good yields under mild conditions. A switch of intramolecular to intermolecular domino Michael–aldol–lactonization leading to differential product formation was achieved by different NHCs catalysis. |
format | Online Article Text |
id | pubmed-9503435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95034352022-09-24 Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones Wang, Zhanyong Yang, Ting Liu, Dongfang Chen, Rongxiang Wang, Nan Liu, Hong Li, Jiarong Wang, Kaikai Liu, Hongxin Molecules Article An efficient, three-component reaction of aldehydes and benzofuran-3-ones was developed. This process provides a new approach for the preparation of synthetically and biologically important spirobenzofuran-3-one derivatives with moderate-to-good yields under mild conditions. A switch of intramolecular to intermolecular domino Michael–aldol–lactonization leading to differential product formation was achieved by different NHCs catalysis. MDPI 2022-09-13 /pmc/articles/PMC9503435/ /pubmed/36144686 http://dx.doi.org/10.3390/molecules27185952 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Zhanyong Yang, Ting Liu, Dongfang Chen, Rongxiang Wang, Nan Liu, Hong Li, Jiarong Wang, Kaikai Liu, Hongxin Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones |
title | Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones |
title_full | Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones |
title_fullStr | Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones |
title_full_unstemmed | Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones |
title_short | Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones |
title_sort | catalyst-controlled selectivity switch in three-component reaction: an nhc-catalyzed strategy for the synthesis of δ-lactone-fused spirobenzofuran-3-ones |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503435/ https://www.ncbi.nlm.nih.gov/pubmed/36144686 http://dx.doi.org/10.3390/molecules27185952 |
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