Cargando…

Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study

Maternal short-chain fatty acids (SCFAs) play a critical role in fetal development and metabolic programming. However, an important gap in the analysis of such relationships is the lack of reference values in pregnant women. Therefore, we establish serum SCFA percentile reference ranges both early a...

Descripción completa

Detalles Bibliográficos
Autores principales: Martín-Grau, Carla, Díaz-López, Andrés, Aparicio, Estefania, Arija, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503449/
https://www.ncbi.nlm.nih.gov/pubmed/36145175
http://dx.doi.org/10.3390/nu14183798
_version_ 1784795965958389760
author Martín-Grau, Carla
Díaz-López, Andrés
Aparicio, Estefania
Arija, Victoria
author_facet Martín-Grau, Carla
Díaz-López, Andrés
Aparicio, Estefania
Arija, Victoria
author_sort Martín-Grau, Carla
collection PubMed
description Maternal short-chain fatty acids (SCFAs) play a critical role in fetal development and metabolic programming. However, an important gap in the analysis of such relationships is the lack of reference values in pregnant women. Therefore, we establish serum SCFA percentile reference ranges both early and later in pregnancy in a population from a Mediterranean region of Northern Spain. A population-based follow-up study involving 455 healthy pregnant women (mean age 30.6 ± 5.0 years) from the ECLIPSES study is conducted. Sociodemographic, obstetric, anthropometric, lifestyle, dietary variables and blood samples were collected in the first and third trimesters. Serum SCFA concentrations were measured by LC-MS/MS. The 2.5/97.5 percentiles of the reference interval for serum acetic, propionic, isobutyric, and butyric acids were 16.4/103.8 µmol/L, 2.1/5.8 µmol/L, 0.16/1.01 µmol/L and 0.32/1.67 µmol/L in the first trimester of pregnancy, respectively. In the third trimester, butyrate levels increased with most of the maternal factors and categories studied, while acetic acid and isobutyric acid decreased only in some maternal categories. Propionic acid was not affected by maternal factors. Reference ranges did not vary with maternal age, body weight, social class or diet, but decreased with smoking, high physical activity, low BMI and primiparity. This study establishes for the first-time SCFAs reference ranges in serum for women in our region in both early and late pregnancy. This information can be useful to monitor pregnancy follow-up and detect risk values.
format Online
Article
Text
id pubmed-9503449
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95034492022-09-24 Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study Martín-Grau, Carla Díaz-López, Andrés Aparicio, Estefania Arija, Victoria Nutrients Article Maternal short-chain fatty acids (SCFAs) play a critical role in fetal development and metabolic programming. However, an important gap in the analysis of such relationships is the lack of reference values in pregnant women. Therefore, we establish serum SCFA percentile reference ranges both early and later in pregnancy in a population from a Mediterranean region of Northern Spain. A population-based follow-up study involving 455 healthy pregnant women (mean age 30.6 ± 5.0 years) from the ECLIPSES study is conducted. Sociodemographic, obstetric, anthropometric, lifestyle, dietary variables and blood samples were collected in the first and third trimesters. Serum SCFA concentrations were measured by LC-MS/MS. The 2.5/97.5 percentiles of the reference interval for serum acetic, propionic, isobutyric, and butyric acids were 16.4/103.8 µmol/L, 2.1/5.8 µmol/L, 0.16/1.01 µmol/L and 0.32/1.67 µmol/L in the first trimester of pregnancy, respectively. In the third trimester, butyrate levels increased with most of the maternal factors and categories studied, while acetic acid and isobutyric acid decreased only in some maternal categories. Propionic acid was not affected by maternal factors. Reference ranges did not vary with maternal age, body weight, social class or diet, but decreased with smoking, high physical activity, low BMI and primiparity. This study establishes for the first-time SCFAs reference ranges in serum for women in our region in both early and late pregnancy. This information can be useful to monitor pregnancy follow-up and detect risk values. MDPI 2022-09-15 /pmc/articles/PMC9503449/ /pubmed/36145175 http://dx.doi.org/10.3390/nu14183798 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martín-Grau, Carla
Díaz-López, Andrés
Aparicio, Estefania
Arija, Victoria
Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study
title Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study
title_full Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study
title_fullStr Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study
title_full_unstemmed Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study
title_short Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study
title_sort short-chain fatty acid reference ranges in pregnant women from a mediterranean region of northern spain: eclipses study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503449/
https://www.ncbi.nlm.nih.gov/pubmed/36145175
http://dx.doi.org/10.3390/nu14183798
work_keys_str_mv AT martingraucarla shortchainfattyacidreferencerangesinpregnantwomenfromamediterraneanregionofnorthernspaineclipsesstudy
AT diazlopezandres shortchainfattyacidreferencerangesinpregnantwomenfromamediterraneanregionofnorthernspaineclipsesstudy
AT aparicioestefania shortchainfattyacidreferencerangesinpregnantwomenfromamediterraneanregionofnorthernspaineclipsesstudy
AT arijavictoria shortchainfattyacidreferencerangesinpregnantwomenfromamediterraneanregionofnorthernspaineclipsesstudy