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The Role of TGFβ and Other Cytokines in Regulating Mast Cell Functions in Allergic Inflammation

Mast cells (MC) are a key effector cell in multiple types of immune responses, including atopic conditions. Allergic diseases have been steadily rising across the globe, creating a growing public health problem. IgE-mediated activation of MCs leads to the release of potent mediators that can have di...

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Detalles Bibliográficos
Autores principales: Haque, Tamara T., Frischmeyer-Guerrerio, Pamela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503477/
https://www.ncbi.nlm.nih.gov/pubmed/36142776
http://dx.doi.org/10.3390/ijms231810864
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author Haque, Tamara T.
Frischmeyer-Guerrerio, Pamela A.
author_facet Haque, Tamara T.
Frischmeyer-Guerrerio, Pamela A.
author_sort Haque, Tamara T.
collection PubMed
description Mast cells (MC) are a key effector cell in multiple types of immune responses, including atopic conditions. Allergic diseases have been steadily rising across the globe, creating a growing public health problem. IgE-mediated activation of MCs leads to the release of potent mediators that can have dire clinical consequences. Current therapeutic options to inhibit MC activation and degranulation are limited; thus, a better understanding of the mechanisms that regulate MC effector functions in allergic inflammation are necessary in order to develop effective treatment options with minimal side effects. Several cytokines have been identified that play multifaceted roles in regulating MC activation, including TGFβ, IL-10, and IL-33, and others that appear to serve primarily anti-inflammatory functions, including IL-35 and IL-37. Here, we review the literature examining cytokines that regulate MC-mediated allergic immune responses.
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spelling pubmed-95034772022-09-24 The Role of TGFβ and Other Cytokines in Regulating Mast Cell Functions in Allergic Inflammation Haque, Tamara T. Frischmeyer-Guerrerio, Pamela A. Int J Mol Sci Review Mast cells (MC) are a key effector cell in multiple types of immune responses, including atopic conditions. Allergic diseases have been steadily rising across the globe, creating a growing public health problem. IgE-mediated activation of MCs leads to the release of potent mediators that can have dire clinical consequences. Current therapeutic options to inhibit MC activation and degranulation are limited; thus, a better understanding of the mechanisms that regulate MC effector functions in allergic inflammation are necessary in order to develop effective treatment options with minimal side effects. Several cytokines have been identified that play multifaceted roles in regulating MC activation, including TGFβ, IL-10, and IL-33, and others that appear to serve primarily anti-inflammatory functions, including IL-35 and IL-37. Here, we review the literature examining cytokines that regulate MC-mediated allergic immune responses. MDPI 2022-09-17 /pmc/articles/PMC9503477/ /pubmed/36142776 http://dx.doi.org/10.3390/ijms231810864 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Haque, Tamara T.
Frischmeyer-Guerrerio, Pamela A.
The Role of TGFβ and Other Cytokines in Regulating Mast Cell Functions in Allergic Inflammation
title The Role of TGFβ and Other Cytokines in Regulating Mast Cell Functions in Allergic Inflammation
title_full The Role of TGFβ and Other Cytokines in Regulating Mast Cell Functions in Allergic Inflammation
title_fullStr The Role of TGFβ and Other Cytokines in Regulating Mast Cell Functions in Allergic Inflammation
title_full_unstemmed The Role of TGFβ and Other Cytokines in Regulating Mast Cell Functions in Allergic Inflammation
title_short The Role of TGFβ and Other Cytokines in Regulating Mast Cell Functions in Allergic Inflammation
title_sort role of tgfβ and other cytokines in regulating mast cell functions in allergic inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503477/
https://www.ncbi.nlm.nih.gov/pubmed/36142776
http://dx.doi.org/10.3390/ijms231810864
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