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Extracellular Vesicles: A New Frontier for Cardiac Repair
The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been used to treat diseases. Growing evidence indicates that EVs play a cardioprotective role in heart disease by activating beneficial signaling pathways. Multiple functional components of EVs a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503573/ https://www.ncbi.nlm.nih.gov/pubmed/36145595 http://dx.doi.org/10.3390/pharmaceutics14091848 |
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author | You, Benshuai Yang, Yang Zhou, Zixuan Yan, Yongmin Zhang, Leilei Jin, Jianhua Qian, Hui |
author_facet | You, Benshuai Yang, Yang Zhou, Zixuan Yan, Yongmin Zhang, Leilei Jin, Jianhua Qian, Hui |
author_sort | You, Benshuai |
collection | PubMed |
description | The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been used to treat diseases. Growing evidence indicates that EVs play a cardioprotective role in heart disease by activating beneficial signaling pathways. Multiple functional components of EVs and intracellular molecular mechanisms are involved in the process. To overcome the shortcomings of native EVs such as their heterogeneity and limited tropism, a series of engineering approaches has been developed to improve the therapeutic efficiency of EVs. In this review, we present an overview of the research and future directions for EVs-based cardiac therapies with an emphasis on EVs-mediated delivery of therapeutic agents. The advantages and limitations of various modification strategies are discussed, and possible opportunities for improvement are proposed. An in-depth understanding of the endogenous properties of EVs and EVs engineering strategies could lead to a promising cell-free therapy for cardiac repair. |
format | Online Article Text |
id | pubmed-9503573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95035732022-09-24 Extracellular Vesicles: A New Frontier for Cardiac Repair You, Benshuai Yang, Yang Zhou, Zixuan Yan, Yongmin Zhang, Leilei Jin, Jianhua Qian, Hui Pharmaceutics Review The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been used to treat diseases. Growing evidence indicates that EVs play a cardioprotective role in heart disease by activating beneficial signaling pathways. Multiple functional components of EVs and intracellular molecular mechanisms are involved in the process. To overcome the shortcomings of native EVs such as their heterogeneity and limited tropism, a series of engineering approaches has been developed to improve the therapeutic efficiency of EVs. In this review, we present an overview of the research and future directions for EVs-based cardiac therapies with an emphasis on EVs-mediated delivery of therapeutic agents. The advantages and limitations of various modification strategies are discussed, and possible opportunities for improvement are proposed. An in-depth understanding of the endogenous properties of EVs and EVs engineering strategies could lead to a promising cell-free therapy for cardiac repair. MDPI 2022-09-01 /pmc/articles/PMC9503573/ /pubmed/36145595 http://dx.doi.org/10.3390/pharmaceutics14091848 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review You, Benshuai Yang, Yang Zhou, Zixuan Yan, Yongmin Zhang, Leilei Jin, Jianhua Qian, Hui Extracellular Vesicles: A New Frontier for Cardiac Repair |
title | Extracellular Vesicles: A New Frontier for Cardiac Repair |
title_full | Extracellular Vesicles: A New Frontier for Cardiac Repair |
title_fullStr | Extracellular Vesicles: A New Frontier for Cardiac Repair |
title_full_unstemmed | Extracellular Vesicles: A New Frontier for Cardiac Repair |
title_short | Extracellular Vesicles: A New Frontier for Cardiac Repair |
title_sort | extracellular vesicles: a new frontier for cardiac repair |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503573/ https://www.ncbi.nlm.nih.gov/pubmed/36145595 http://dx.doi.org/10.3390/pharmaceutics14091848 |
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