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Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury

Acute kidney injury (AKI) is a leading complication in hospitalized patients of different disciplines due to various aetiologies and is associated with the risk of chronic kidney disease, the need for dialysis and death. Since nephrons are not supplied with pain signals, kidney injury is mostly diag...

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Autores principales: Pajenda, Sahra, Wagner, Ludwig, Gerges, Daniela, Herkner, Harald, Tevdoradze, Tamar, Mechtler, Karl, Schmidt, Alice, Winnicki, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503639/
https://www.ncbi.nlm.nih.gov/pubmed/36143426
http://dx.doi.org/10.3390/life12091391
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author Pajenda, Sahra
Wagner, Ludwig
Gerges, Daniela
Herkner, Harald
Tevdoradze, Tamar
Mechtler, Karl
Schmidt, Alice
Winnicki, Wolfgang
author_facet Pajenda, Sahra
Wagner, Ludwig
Gerges, Daniela
Herkner, Harald
Tevdoradze, Tamar
Mechtler, Karl
Schmidt, Alice
Winnicki, Wolfgang
author_sort Pajenda, Sahra
collection PubMed
description Acute kidney injury (AKI) is a leading complication in hospitalized patients of different disciplines due to various aetiologies and is associated with the risk of chronic kidney disease, the need for dialysis and death. Since nephrons are not supplied with pain signals, kidney injury is mostly diagnosed by serum creatinine with a time delay. Recent work has shown that certain urinary biomarkers are available for early detection of AKI. In total, 155 subjects, including 102 patients with AKI at various stages and 53 subjects without AKI, were enrolled, and their course and laboratory data were recorded. Urinary collectrin (TMEM27) was measured by a commercially available ELISA assay. Changes in serum creatinine were used to determine AKI stage. Patients with AKI presented with significantly lower levels of urinary collectrin compared to patients without AKI (1597 ± 1827 pg/mL vs. 2855 ± 2073; p = 0.001). Collectrin was found to inversely correlate with serum creatinine and stages of AKI. Collectrin levels were lowest in AKI stage III (1576 ± 1686 pg/mL; p = 0.001) and also significantly lower in stage II (1616 ± 2148 pg/mL; p = 0.021) and stage I (1630 ± 1956 pg/mL; p = 0.019) compared to subjects without AKI. An optimal minimum collectrin cut-off value of 1606 [95% CI 1258 to 1954] pg/mL was determined to detect AKI. In conclusion, urinary collectrin represents an indicator of AKI that, unlike all other established AKI biomarkers, decreases with stage of AKI and thus may be associated with a novel pathogenic pathway.
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spelling pubmed-95036392022-09-24 Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury Pajenda, Sahra Wagner, Ludwig Gerges, Daniela Herkner, Harald Tevdoradze, Tamar Mechtler, Karl Schmidt, Alice Winnicki, Wolfgang Life (Basel) Article Acute kidney injury (AKI) is a leading complication in hospitalized patients of different disciplines due to various aetiologies and is associated with the risk of chronic kidney disease, the need for dialysis and death. Since nephrons are not supplied with pain signals, kidney injury is mostly diagnosed by serum creatinine with a time delay. Recent work has shown that certain urinary biomarkers are available for early detection of AKI. In total, 155 subjects, including 102 patients with AKI at various stages and 53 subjects without AKI, were enrolled, and their course and laboratory data were recorded. Urinary collectrin (TMEM27) was measured by a commercially available ELISA assay. Changes in serum creatinine were used to determine AKI stage. Patients with AKI presented with significantly lower levels of urinary collectrin compared to patients without AKI (1597 ± 1827 pg/mL vs. 2855 ± 2073; p = 0.001). Collectrin was found to inversely correlate with serum creatinine and stages of AKI. Collectrin levels were lowest in AKI stage III (1576 ± 1686 pg/mL; p = 0.001) and also significantly lower in stage II (1616 ± 2148 pg/mL; p = 0.021) and stage I (1630 ± 1956 pg/mL; p = 0.019) compared to subjects without AKI. An optimal minimum collectrin cut-off value of 1606 [95% CI 1258 to 1954] pg/mL was determined to detect AKI. In conclusion, urinary collectrin represents an indicator of AKI that, unlike all other established AKI biomarkers, decreases with stage of AKI and thus may be associated with a novel pathogenic pathway. MDPI 2022-09-06 /pmc/articles/PMC9503639/ /pubmed/36143426 http://dx.doi.org/10.3390/life12091391 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pajenda, Sahra
Wagner, Ludwig
Gerges, Daniela
Herkner, Harald
Tevdoradze, Tamar
Mechtler, Karl
Schmidt, Alice
Winnicki, Wolfgang
Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury
title Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury
title_full Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury
title_fullStr Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury
title_full_unstemmed Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury
title_short Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury
title_sort urinary collectrin (tmem27) as novel marker for acute kidney injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503639/
https://www.ncbi.nlm.nih.gov/pubmed/36143426
http://dx.doi.org/10.3390/life12091391
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