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Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD
Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the moment, therapy alternatives demonstrate limited...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503665/ https://www.ncbi.nlm.nih.gov/pubmed/36145321 http://dx.doi.org/10.3390/ph15091100 |
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author | Kostareva, Irina Kirgizov, Kirill Machneva, Elena Ustyuzhanina, Nadezhda Nifantiev, Nikolay Skvortsova, Yulia Shubina, Irina Reshetnikova, Vera Valiev, Timur Varfolomeeva, Svetlana Kiselevskiy, Mikhail |
author_facet | Kostareva, Irina Kirgizov, Kirill Machneva, Elena Ustyuzhanina, Nadezhda Nifantiev, Nikolay Skvortsova, Yulia Shubina, Irina Reshetnikova, Vera Valiev, Timur Varfolomeeva, Svetlana Kiselevskiy, Mikhail |
author_sort | Kostareva, Irina |
collection | PubMed |
description | Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the moment, therapy alternatives demonstrate limited effectiveness in steroid-refractory illness; in addition, we have no reliable data on the mechanism of this condition. The lack of drugs of choice for the treatment of GVHD underscores the significance of the design of new therapies. Improved understanding of the mechanism of chronic GVHD has secured new therapy goals, and organized diagnostic recommendations and the development of medical tests have ensured a general language and routes for studies in this field. These factors, combined with the rapid development of pharmacology, have helped speed up the search of medicines and medical studies regarding chronic GVHD. At present, we can hope for success in curing this formidable complication. This review summarizes the latest clinical developments in new treatments for chronic GVHD. |
format | Online Article Text |
id | pubmed-9503665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95036652022-09-24 Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD Kostareva, Irina Kirgizov, Kirill Machneva, Elena Ustyuzhanina, Nadezhda Nifantiev, Nikolay Skvortsova, Yulia Shubina, Irina Reshetnikova, Vera Valiev, Timur Varfolomeeva, Svetlana Kiselevskiy, Mikhail Pharmaceuticals (Basel) Review Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the moment, therapy alternatives demonstrate limited effectiveness in steroid-refractory illness; in addition, we have no reliable data on the mechanism of this condition. The lack of drugs of choice for the treatment of GVHD underscores the significance of the design of new therapies. Improved understanding of the mechanism of chronic GVHD has secured new therapy goals, and organized diagnostic recommendations and the development of medical tests have ensured a general language and routes for studies in this field. These factors, combined with the rapid development of pharmacology, have helped speed up the search of medicines and medical studies regarding chronic GVHD. At present, we can hope for success in curing this formidable complication. This review summarizes the latest clinical developments in new treatments for chronic GVHD. MDPI 2022-09-03 /pmc/articles/PMC9503665/ /pubmed/36145321 http://dx.doi.org/10.3390/ph15091100 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kostareva, Irina Kirgizov, Kirill Machneva, Elena Ustyuzhanina, Nadezhda Nifantiev, Nikolay Skvortsova, Yulia Shubina, Irina Reshetnikova, Vera Valiev, Timur Varfolomeeva, Svetlana Kiselevskiy, Mikhail Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD |
title | Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD |
title_full | Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD |
title_fullStr | Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD |
title_full_unstemmed | Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD |
title_short | Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD |
title_sort | novel and promising strategies for therapy of post-transplant chronic gvhd |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503665/ https://www.ncbi.nlm.nih.gov/pubmed/36145321 http://dx.doi.org/10.3390/ph15091100 |
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