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Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD

Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the moment, therapy alternatives demonstrate limited...

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Autores principales: Kostareva, Irina, Kirgizov, Kirill, Machneva, Elena, Ustyuzhanina, Nadezhda, Nifantiev, Nikolay, Skvortsova, Yulia, Shubina, Irina, Reshetnikova, Vera, Valiev, Timur, Varfolomeeva, Svetlana, Kiselevskiy, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503665/
https://www.ncbi.nlm.nih.gov/pubmed/36145321
http://dx.doi.org/10.3390/ph15091100
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author Kostareva, Irina
Kirgizov, Kirill
Machneva, Elena
Ustyuzhanina, Nadezhda
Nifantiev, Nikolay
Skvortsova, Yulia
Shubina, Irina
Reshetnikova, Vera
Valiev, Timur
Varfolomeeva, Svetlana
Kiselevskiy, Mikhail
author_facet Kostareva, Irina
Kirgizov, Kirill
Machneva, Elena
Ustyuzhanina, Nadezhda
Nifantiev, Nikolay
Skvortsova, Yulia
Shubina, Irina
Reshetnikova, Vera
Valiev, Timur
Varfolomeeva, Svetlana
Kiselevskiy, Mikhail
author_sort Kostareva, Irina
collection PubMed
description Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the moment, therapy alternatives demonstrate limited effectiveness in steroid-refractory illness; in addition, we have no reliable data on the mechanism of this condition. The lack of drugs of choice for the treatment of GVHD underscores the significance of the design of new therapies. Improved understanding of the mechanism of chronic GVHD has secured new therapy goals, and organized diagnostic recommendations and the development of medical tests have ensured a general language and routes for studies in this field. These factors, combined with the rapid development of pharmacology, have helped speed up the search of medicines and medical studies regarding chronic GVHD. At present, we can hope for success in curing this formidable complication. This review summarizes the latest clinical developments in new treatments for chronic GVHD.
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spelling pubmed-95036652022-09-24 Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD Kostareva, Irina Kirgizov, Kirill Machneva, Elena Ustyuzhanina, Nadezhda Nifantiev, Nikolay Skvortsova, Yulia Shubina, Irina Reshetnikova, Vera Valiev, Timur Varfolomeeva, Svetlana Kiselevskiy, Mikhail Pharmaceuticals (Basel) Review Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the moment, therapy alternatives demonstrate limited effectiveness in steroid-refractory illness; in addition, we have no reliable data on the mechanism of this condition. The lack of drugs of choice for the treatment of GVHD underscores the significance of the design of new therapies. Improved understanding of the mechanism of chronic GVHD has secured new therapy goals, and organized diagnostic recommendations and the development of medical tests have ensured a general language and routes for studies in this field. These factors, combined with the rapid development of pharmacology, have helped speed up the search of medicines and medical studies regarding chronic GVHD. At present, we can hope for success in curing this formidable complication. This review summarizes the latest clinical developments in new treatments for chronic GVHD. MDPI 2022-09-03 /pmc/articles/PMC9503665/ /pubmed/36145321 http://dx.doi.org/10.3390/ph15091100 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kostareva, Irina
Kirgizov, Kirill
Machneva, Elena
Ustyuzhanina, Nadezhda
Nifantiev, Nikolay
Skvortsova, Yulia
Shubina, Irina
Reshetnikova, Vera
Valiev, Timur
Varfolomeeva, Svetlana
Kiselevskiy, Mikhail
Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD
title Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD
title_full Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD
title_fullStr Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD
title_full_unstemmed Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD
title_short Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD
title_sort novel and promising strategies for therapy of post-transplant chronic gvhd
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503665/
https://www.ncbi.nlm.nih.gov/pubmed/36145321
http://dx.doi.org/10.3390/ph15091100
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