Cargando…

Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor

While antiretroviral drugs have transformed the lives of HIV-infected individuals, chronic treatment is required to prevent rebound from viral reservoir cells. People living with HIV also are at higher risk for cardiovascular and neurocognitive complications, as well as cancer. Finding a cure for HI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Emert-Sedlak, Lori A., Shi, Haibin, Tice, Colin M., Chen, Li, Alvarado, John J., Shu, Sherry T., Du, Shoucheng, Thomas, Catherine E., Wrobel, Jay E., Reitz, Allen B., Smithgall, Thomas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503669/ https://www.ncbi.nlm.nih.gov/pubmed/36146831 http://dx.doi.org/10.3390/v14092025

Ejemplares similares

Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen
por: Trible, Ronald P, et al.
Publicado: (2013)

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck
por: Pene-Dumitrescu, Teodora, et al.
Publicado: (2012)

Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action
por: Dikeakos, Jimmy D., et al.
Publicado: (2010)

A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding
por: Wu, Mousheng, et al.
Publicado: (2018)

Nef Alleles from All Major HIV-1 Clades Activate Src-Family Kinases and Enhance HIV-1 Replication in an Inhibitor-Sensitive Manner
por: Narute, Purushottam S., et al.
Publicado: (2012)

HIV-1 Nef Promotes Survival of Myeloid Cells by a Stat3-dependent Pathway
por: Briggs, Scott D., et al.
Publicado: (2001)

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity
por: Perrone, Rosalba, et al.
Publicado: (2013)

T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy
por: Thomas, Allison S., et al.
Publicado: (2017)

The Persistence of HIV Diversity, Transcription, and Nef Protein in Kaposi’s Sarcoma Tumors during Antiretroviral Therapy
por: Nolan, David J., et al.
Publicado: (2022)

Use of pediatric thymus to humanize mice for HIV-1 mucosal transmission
por: Roy, Chandra N., et al.
Publicado: (2023)

Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function
por: Grover, Prerna, et al.
Publicado: (2015)

Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck
por: Dorman, Heather R., et al.
Publicado: (2019)

HIV-1 Nef: at the crossroads
por: Foster, John L, et al.
Publicado: (2008)

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities
por: Martínez-Bonet, Marta, et al.
Publicado: (2015)

Aberrant Autophagy in Macrophages and Astrocytes after HIV Nef or Antiretroviral Treatment: Contribution to the Pathogenesis of HIV-associated Neurocognitive Disorders
por: Cheney, Laura, et al.
Publicado: (2017)

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages
por: Mwimanzi, Philip, et al.
Publicado: (2011)

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity
por: Sami Saribas, A, et al.
Publicado: (2017)

Self-association of the Lentivirus protein, Nef
por: Kwak, Youn Tae, et al.
Publicado: (2010)

The activity of Nef on HIV-1 infectivity
por: Basmaciogullari, Stéphane, et al.
Publicado: (2014)

HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders
por: Cheney, Laura, et al.
Publicado: (2020)

P03-04. Increased virulence of CAEV chimeras expressing Nef and Vpx/Vpr accessory proteins in infected goats
por: Jin, Y, et al.
Publicado: (2009)

Alterations in intracellular potassium concentration by HIV-1 and SIV Nef
por: Choi, Bongkun, et al.
Publicado: (2008)

c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution
por: Badger, John, et al.
Publicado: (2016)

HIV-1 release requires Nef-induced caspase activation
por: Segura, Jason, et al.
Publicado: (2023)

HIV-1 Nef targets calnexin: a novel mechanism behind Nef effects on host cell and viral proteins
por: Jennelle, Lucas, et al.
Publicado: (2013)

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
por: Naicker, Delon, et al.
Publicado: (2023)

Nef-mediated Clathrin-coated Pit Formation
por: Foti, Michelangelo, et al.
Publicado: (1997)

Exosomes Are Unlikely Involved in Intercellular Nef Transfer
por: Luo, Xiaoyu, et al.
Publicado: (2015)

TNF and HIV-1 Nef: An Intimate Interplay
por: Herbein, Georges
Publicado: (2016)

Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis
por: Serra-Moreno, Ruth, et al.
Publicado: (2013)

Genetic defects in the nef gene are associated with Korean Red Ginseng intake: monitoring of nef sequence polymorphisms over 20 years
por: Cho, Young-Keol, et al.
Publicado: (2017)

The impact of antiretroviral therapy on population-level virulence evolution of HIV-1
por: Roberts, Hannah E., et al.
Publicado: (2015)

Limited HIV-1 Subtype C nef 3′PPT Variation in Combination Antiretroviral Therapy Naïve and Experienced People Living with HIV in Botswana
por: Seatla, Kaelo K., et al.
Publicado: (2021)

Protein cargo of Nef-containing exosomal extracellular vesicles may predict HIV-associated Neurocognitive Impairment status
por: Caobi, Allen, et al.
Publicado: (2023)

Chemotactic activity of HIV-1 Nef for human monocytes
por: Lehmann, MH, et al.
Publicado: (2006)

The Nef-Infectivity Enigma: Mechanisms of Enhanced Lentiviral Infection
por: Vermeire, Jolien, et al.
Publicado: (2011)

Understanding the nature of the Nef requirement for HIV-1 infectivity
por: Rosa, Annachiara, et al.
Publicado: (2013)

HIV-1 Nef blocks autophagy in human astrocytes
por: Sardo, Luca, et al.
Publicado: (2015)

Neuromorphic NEF-Based Inverse Kinematics and PID Control
por: Zaidel, Yuval, et al.
Publicado: (2021)

Synergy and allostery in ligand binding by HIV-1 Nef
por: Aldehaiman, Abdullah, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3d346pu7enmu1933b4h27n4d89