Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells

Allo-HSCT with CCR5Δ32/Δ32 donor cells is the only curative HIV-1 intervention. We investigated the impact of allo-HSCT on the viral reservoir in PBMCs and post-mortem tissue in two patients. IciS-05 and IciS-11 both received a CCR5Δ32/Δ32 allo-HSCT. Before allo-HSCT, ultrasensitive HIV-1 RNA quanti...

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Autores principales: Huyveneers, Laura E. P., Bruns, Anke, Stam, Arjen, Ellerbroek, Pauline, de Jong, Dorien, Nagy, Noémi A., Gumbs, Stephanie B. H., Tesselaar, Kiki, Bosman, Kobus, Salgado, Maria, Hütter, Gero, Brosens, Lodewijk A. A., Kwon, Mi, Diez Martin, Jose, van der Meer, Jan T. M., de Kort, Theun M., Sáez-Cirión, Asier, Schulze zur Wiesch, Julian, Boelens, Jaap Jan, Martinez-Picado, Javier, Kuball, Jürgen H. E., Wensing, Annemarie M. J., Nijhuis, Monique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503691/
https://www.ncbi.nlm.nih.gov/pubmed/36146874
http://dx.doi.org/10.3390/v14092069

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