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Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications

Bioactive collagen–chitosan–lemongrass (COL–CS–LG) membranes were prepared by casting method and analyzed for potential biomedical applications. For COL–CS–LG membranes, LG essential oil release, antioxidant properties, in vitro cytotoxicity and antimicrobial assessments were conducted, as well as f...

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Autores principales: Râpă, Maria, Zaharescu, Traian, Stefan, Laura Mihaela, Gaidău, Carmen, Stănculescu, Ioana, Constantinescu, Rodica Roxana, Stanca, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503703/
https://www.ncbi.nlm.nih.gov/pubmed/36146031
http://dx.doi.org/10.3390/polym14183884
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author Râpă, Maria
Zaharescu, Traian
Stefan, Laura Mihaela
Gaidău, Carmen
Stănculescu, Ioana
Constantinescu, Rodica Roxana
Stanca, Maria
author_facet Râpă, Maria
Zaharescu, Traian
Stefan, Laura Mihaela
Gaidău, Carmen
Stănculescu, Ioana
Constantinescu, Rodica Roxana
Stanca, Maria
author_sort Râpă, Maria
collection PubMed
description Bioactive collagen–chitosan–lemongrass (COL–CS–LG) membranes were prepared by casting method and analyzed for potential biomedical applications. For COL–CS–LG membranes, LG essential oil release, antioxidant properties, in vitro cytotoxicity and antimicrobial assessments were conducted, as well as free radical determination after gamma irradiation by chemiluminescence, and structural characteristics analysis through Attenuated Total Reflection–Fourier Transform Infrared Spectroscopy (ATR–FTIR) and Differential Scanning Calorimetry (DSC). The evaluation of non-isothermal chemiluminescence after gamma radiation exposure to COL–CS–LG membranes revealed a slowing down of the oxidation process at temperatures exceeding 200 °C, in correlation with antioxidant activity. Antimicrobial properties and minimum inhibitory concentrations were found to be in correlation with cytotoxicity limits, offering the optimum composition for designing new biomaterials.
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spelling pubmed-95037032022-09-24 Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications Râpă, Maria Zaharescu, Traian Stefan, Laura Mihaela Gaidău, Carmen Stănculescu, Ioana Constantinescu, Rodica Roxana Stanca, Maria Polymers (Basel) Article Bioactive collagen–chitosan–lemongrass (COL–CS–LG) membranes were prepared by casting method and analyzed for potential biomedical applications. For COL–CS–LG membranes, LG essential oil release, antioxidant properties, in vitro cytotoxicity and antimicrobial assessments were conducted, as well as free radical determination after gamma irradiation by chemiluminescence, and structural characteristics analysis through Attenuated Total Reflection–Fourier Transform Infrared Spectroscopy (ATR–FTIR) and Differential Scanning Calorimetry (DSC). The evaluation of non-isothermal chemiluminescence after gamma radiation exposure to COL–CS–LG membranes revealed a slowing down of the oxidation process at temperatures exceeding 200 °C, in correlation with antioxidant activity. Antimicrobial properties and minimum inhibitory concentrations were found to be in correlation with cytotoxicity limits, offering the optimum composition for designing new biomaterials. MDPI 2022-09-17 /pmc/articles/PMC9503703/ /pubmed/36146031 http://dx.doi.org/10.3390/polym14183884 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Râpă, Maria
Zaharescu, Traian
Stefan, Laura Mihaela
Gaidău, Carmen
Stănculescu, Ioana
Constantinescu, Rodica Roxana
Stanca, Maria
Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications
title Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications
title_full Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications
title_fullStr Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications
title_full_unstemmed Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications
title_short Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications
title_sort bioactivity and thermal stability of collagen–chitosan containing lemongrass essential oil for potential medical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503703/
https://www.ncbi.nlm.nih.gov/pubmed/36146031
http://dx.doi.org/10.3390/polym14183884
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