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Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications
Bioactive collagen–chitosan–lemongrass (COL–CS–LG) membranes were prepared by casting method and analyzed for potential biomedical applications. For COL–CS–LG membranes, LG essential oil release, antioxidant properties, in vitro cytotoxicity and antimicrobial assessments were conducted, as well as f...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503703/ https://www.ncbi.nlm.nih.gov/pubmed/36146031 http://dx.doi.org/10.3390/polym14183884 |
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author | Râpă, Maria Zaharescu, Traian Stefan, Laura Mihaela Gaidău, Carmen Stănculescu, Ioana Constantinescu, Rodica Roxana Stanca, Maria |
author_facet | Râpă, Maria Zaharescu, Traian Stefan, Laura Mihaela Gaidău, Carmen Stănculescu, Ioana Constantinescu, Rodica Roxana Stanca, Maria |
author_sort | Râpă, Maria |
collection | PubMed |
description | Bioactive collagen–chitosan–lemongrass (COL–CS–LG) membranes were prepared by casting method and analyzed for potential biomedical applications. For COL–CS–LG membranes, LG essential oil release, antioxidant properties, in vitro cytotoxicity and antimicrobial assessments were conducted, as well as free radical determination after gamma irradiation by chemiluminescence, and structural characteristics analysis through Attenuated Total Reflection–Fourier Transform Infrared Spectroscopy (ATR–FTIR) and Differential Scanning Calorimetry (DSC). The evaluation of non-isothermal chemiluminescence after gamma radiation exposure to COL–CS–LG membranes revealed a slowing down of the oxidation process at temperatures exceeding 200 °C, in correlation with antioxidant activity. Antimicrobial properties and minimum inhibitory concentrations were found to be in correlation with cytotoxicity limits, offering the optimum composition for designing new biomaterials. |
format | Online Article Text |
id | pubmed-9503703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95037032022-09-24 Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications Râpă, Maria Zaharescu, Traian Stefan, Laura Mihaela Gaidău, Carmen Stănculescu, Ioana Constantinescu, Rodica Roxana Stanca, Maria Polymers (Basel) Article Bioactive collagen–chitosan–lemongrass (COL–CS–LG) membranes were prepared by casting method and analyzed for potential biomedical applications. For COL–CS–LG membranes, LG essential oil release, antioxidant properties, in vitro cytotoxicity and antimicrobial assessments were conducted, as well as free radical determination after gamma irradiation by chemiluminescence, and structural characteristics analysis through Attenuated Total Reflection–Fourier Transform Infrared Spectroscopy (ATR–FTIR) and Differential Scanning Calorimetry (DSC). The evaluation of non-isothermal chemiluminescence after gamma radiation exposure to COL–CS–LG membranes revealed a slowing down of the oxidation process at temperatures exceeding 200 °C, in correlation with antioxidant activity. Antimicrobial properties and minimum inhibitory concentrations were found to be in correlation with cytotoxicity limits, offering the optimum composition for designing new biomaterials. MDPI 2022-09-17 /pmc/articles/PMC9503703/ /pubmed/36146031 http://dx.doi.org/10.3390/polym14183884 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Râpă, Maria Zaharescu, Traian Stefan, Laura Mihaela Gaidău, Carmen Stănculescu, Ioana Constantinescu, Rodica Roxana Stanca, Maria Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications |
title | Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications |
title_full | Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications |
title_fullStr | Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications |
title_full_unstemmed | Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications |
title_short | Bioactivity and Thermal Stability of Collagen–Chitosan Containing Lemongrass Essential Oil for Potential Medical Applications |
title_sort | bioactivity and thermal stability of collagen–chitosan containing lemongrass essential oil for potential medical applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503703/ https://www.ncbi.nlm.nih.gov/pubmed/36146031 http://dx.doi.org/10.3390/polym14183884 |
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