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Antioxidant, Antibacterial, and Antifungal Activities of the Ethanolic Extract Obtained from Berberis vulgaris Roots and Leaves

This work assessed the phenolic and flavonoid components and their antioxidant, antifungal, and antibacterial effects in the ethanolic extract of barberry leaf and roots. The antibactericidal activity of root and leaf extracts against pathogenic bacteria was tested using agar diffusion and microdilu...

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Autores principales: El-Zahar, Khaled Meghawry, Al-Jamaan, Mubarak Eid, Al-Mutairi, Faisal Rasmi, Al-Hudiab, Abdallah Mohamed, Al-Einzi, Mohamed Saleh, Mohamed, Ahmed Abdel-Zaher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503718/
https://www.ncbi.nlm.nih.gov/pubmed/36144846
http://dx.doi.org/10.3390/molecules27186114
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author El-Zahar, Khaled Meghawry
Al-Jamaan, Mubarak Eid
Al-Mutairi, Faisal Rasmi
Al-Hudiab, Abdallah Mohamed
Al-Einzi, Mohamed Saleh
Mohamed, Ahmed Abdel-Zaher
author_facet El-Zahar, Khaled Meghawry
Al-Jamaan, Mubarak Eid
Al-Mutairi, Faisal Rasmi
Al-Hudiab, Abdallah Mohamed
Al-Einzi, Mohamed Saleh
Mohamed, Ahmed Abdel-Zaher
author_sort El-Zahar, Khaled Meghawry
collection PubMed
description This work assessed the phenolic and flavonoid components and their antioxidant, antifungal, and antibacterial effects in the ethanolic extract of barberry leaf and roots. The antibactericidal activity of root and leaf extracts against pathogenic bacteria was tested using agar diffusion and microdilution broth production for the lowest inhibitory concentration (MIC). Berberis vulgaris root and leaf extracts inhibited Staphylococcus aureus ATCC9973, Escherichia coli HB101, Staphylococcus enteritis, and Escherichia coli Cip812. The disc assay technique was used to assess the bactericidal activity of the extracts versus both pathogenic Gram-positive and Gram-negative strains. Hydro alcoholic extract was more effective against bacterial than fungal strains. The results showed that Berberis vulgaris leaf and roots extract had similar antifungal activities. Berberis vulgaris root extract inhibited the mycelial growth of Penicillium verrucosum, Fusarium proliferatum, Aspergillus ochraceous, Aspergillus niger, and Aspergillus flavus. Berberis vulgaris root extract has excellent antioxidant, antibacterial, and antifungal effects. Berberis vulgaris exhibited antimicrobial activity in vitro, and MIC showed that Berberis vulgaris parts efficiently affected pathogens in vitro. In conclusion, both Berberis vulgaris roots and leaves have considerable antibacterial activity and can be used as a source of antibacterial, antioxidant, and bioactive compounds to benefit human health.
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spelling pubmed-95037182022-09-24 Antioxidant, Antibacterial, and Antifungal Activities of the Ethanolic Extract Obtained from Berberis vulgaris Roots and Leaves El-Zahar, Khaled Meghawry Al-Jamaan, Mubarak Eid Al-Mutairi, Faisal Rasmi Al-Hudiab, Abdallah Mohamed Al-Einzi, Mohamed Saleh Mohamed, Ahmed Abdel-Zaher Molecules Article This work assessed the phenolic and flavonoid components and their antioxidant, antifungal, and antibacterial effects in the ethanolic extract of barberry leaf and roots. The antibactericidal activity of root and leaf extracts against pathogenic bacteria was tested using agar diffusion and microdilution broth production for the lowest inhibitory concentration (MIC). Berberis vulgaris root and leaf extracts inhibited Staphylococcus aureus ATCC9973, Escherichia coli HB101, Staphylococcus enteritis, and Escherichia coli Cip812. The disc assay technique was used to assess the bactericidal activity of the extracts versus both pathogenic Gram-positive and Gram-negative strains. Hydro alcoholic extract was more effective against bacterial than fungal strains. The results showed that Berberis vulgaris leaf and roots extract had similar antifungal activities. Berberis vulgaris root extract inhibited the mycelial growth of Penicillium verrucosum, Fusarium proliferatum, Aspergillus ochraceous, Aspergillus niger, and Aspergillus flavus. Berberis vulgaris root extract has excellent antioxidant, antibacterial, and antifungal effects. Berberis vulgaris exhibited antimicrobial activity in vitro, and MIC showed that Berberis vulgaris parts efficiently affected pathogens in vitro. In conclusion, both Berberis vulgaris roots and leaves have considerable antibacterial activity and can be used as a source of antibacterial, antioxidant, and bioactive compounds to benefit human health. MDPI 2022-09-19 /pmc/articles/PMC9503718/ /pubmed/36144846 http://dx.doi.org/10.3390/molecules27186114 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
El-Zahar, Khaled Meghawry
Al-Jamaan, Mubarak Eid
Al-Mutairi, Faisal Rasmi
Al-Hudiab, Abdallah Mohamed
Al-Einzi, Mohamed Saleh
Mohamed, Ahmed Abdel-Zaher
Antioxidant, Antibacterial, and Antifungal Activities of the Ethanolic Extract Obtained from Berberis vulgaris Roots and Leaves
title Antioxidant, Antibacterial, and Antifungal Activities of the Ethanolic Extract Obtained from Berberis vulgaris Roots and Leaves
title_full Antioxidant, Antibacterial, and Antifungal Activities of the Ethanolic Extract Obtained from Berberis vulgaris Roots and Leaves
title_fullStr Antioxidant, Antibacterial, and Antifungal Activities of the Ethanolic Extract Obtained from Berberis vulgaris Roots and Leaves
title_full_unstemmed Antioxidant, Antibacterial, and Antifungal Activities of the Ethanolic Extract Obtained from Berberis vulgaris Roots and Leaves
title_short Antioxidant, Antibacterial, and Antifungal Activities of the Ethanolic Extract Obtained from Berberis vulgaris Roots and Leaves
title_sort antioxidant, antibacterial, and antifungal activities of the ethanolic extract obtained from berberis vulgaris roots and leaves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503718/
https://www.ncbi.nlm.nih.gov/pubmed/36144846
http://dx.doi.org/10.3390/molecules27186114
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