Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications

Modified vaccinia virus Ankara (MVA) is a promising viral vector for vaccine development. MVA is well studied and has been widely used for vaccination against smallpox in Germany. This review describes the history of the origin of the virus and its properties as a vaccine, including a high safety pr...

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Autores principales: Orlova, Olga Vladimirovna, Glazkova, Dina Viktorovna, Bogoslovskaya, Elena Vladimirovna, Shipulin, German Alexandrovich, Yudin, Sergey Mikhailovich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503770/
https://www.ncbi.nlm.nih.gov/pubmed/36146594
http://dx.doi.org/10.3390/vaccines10091516
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author Orlova, Olga Vladimirovna
Glazkova, Dina Viktorovna
Bogoslovskaya, Elena Vladimirovna
Shipulin, German Alexandrovich
Yudin, Sergey Mikhailovich
author_facet Orlova, Olga Vladimirovna
Glazkova, Dina Viktorovna
Bogoslovskaya, Elena Vladimirovna
Shipulin, German Alexandrovich
Yudin, Sergey Mikhailovich
author_sort Orlova, Olga Vladimirovna
collection PubMed
description Modified vaccinia virus Ankara (MVA) is a promising viral vector for vaccine development. MVA is well studied and has been widely used for vaccination against smallpox in Germany. This review describes the history of the origin of the virus and its properties as a vaccine, including a high safety profile. In recent years, MVA has found its place as a vector for the creation of vaccines against various diseases. To date, a large number of vaccine candidates based on the MVA vector have already been developed, many of which have been tested in preclinical and clinical studies. We discuss data on the immunogenicity and efficacy of some of these vaccines.
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spelling pubmed-95037702022-09-24 Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications Orlova, Olga Vladimirovna Glazkova, Dina Viktorovna Bogoslovskaya, Elena Vladimirovna Shipulin, German Alexandrovich Yudin, Sergey Mikhailovich Vaccines (Basel) Review Modified vaccinia virus Ankara (MVA) is a promising viral vector for vaccine development. MVA is well studied and has been widely used for vaccination against smallpox in Germany. This review describes the history of the origin of the virus and its properties as a vaccine, including a high safety profile. In recent years, MVA has found its place as a vector for the creation of vaccines against various diseases. To date, a large number of vaccine candidates based on the MVA vector have already been developed, many of which have been tested in preclinical and clinical studies. We discuss data on the immunogenicity and efficacy of some of these vaccines. MDPI 2022-09-13 /pmc/articles/PMC9503770/ /pubmed/36146594 http://dx.doi.org/10.3390/vaccines10091516 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Orlova, Olga Vladimirovna
Glazkova, Dina Viktorovna
Bogoslovskaya, Elena Vladimirovna
Shipulin, German Alexandrovich
Yudin, Sergey Mikhailovich
Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications
title Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications
title_full Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications
title_fullStr Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications
title_full_unstemmed Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications
title_short Development of Modified Vaccinia Virus Ankara-Based Vaccines: Advantages and Applications
title_sort development of modified vaccinia virus ankara-based vaccines: advantages and applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503770/
https://www.ncbi.nlm.nih.gov/pubmed/36146594
http://dx.doi.org/10.3390/vaccines10091516
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