Cargando…
Complexation: An Interesting Pathway for Combining Two APIs at the Solid State
Combining different drugs into a single crystal form is one of the current challenges in crystal engineering, with the number of reported multi-drug solid forms remaining limited. This paper builds upon an efficient approach to combining Active Pharmaceutical Ingredients (APIs) containing carboxylic...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503796/ https://www.ncbi.nlm.nih.gov/pubmed/36145706 http://dx.doi.org/10.3390/pharmaceutics14091960 |
_version_ | 1784796054732931072 |
---|---|
author | Leng, Fucheng Shemchuk, Oleksii Robeyns, Koen Leyssens, Tom |
author_facet | Leng, Fucheng Shemchuk, Oleksii Robeyns, Koen Leyssens, Tom |
author_sort | Leng, Fucheng |
collection | PubMed |
description | Combining different drugs into a single crystal form is one of the current challenges in crystal engineering, with the number of reported multi-drug solid forms remaining limited. This paper builds upon an efficient approach to combining Active Pharmaceutical Ingredients (APIs) containing carboxylic groups in their structure with APIs containing pyridine moieties. By transforming the former into their zinc salts, they can be successfully combined with the pyridine-containing APIs. This work highlights the successfulness of this approach, as well as the improvement in the physical properties of the obtained solid forms. |
format | Online Article Text |
id | pubmed-9503796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95037962022-09-24 Complexation: An Interesting Pathway for Combining Two APIs at the Solid State Leng, Fucheng Shemchuk, Oleksii Robeyns, Koen Leyssens, Tom Pharmaceutics Article Combining different drugs into a single crystal form is one of the current challenges in crystal engineering, with the number of reported multi-drug solid forms remaining limited. This paper builds upon an efficient approach to combining Active Pharmaceutical Ingredients (APIs) containing carboxylic groups in their structure with APIs containing pyridine moieties. By transforming the former into their zinc salts, they can be successfully combined with the pyridine-containing APIs. This work highlights the successfulness of this approach, as well as the improvement in the physical properties of the obtained solid forms. MDPI 2022-09-16 /pmc/articles/PMC9503796/ /pubmed/36145706 http://dx.doi.org/10.3390/pharmaceutics14091960 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Leng, Fucheng Shemchuk, Oleksii Robeyns, Koen Leyssens, Tom Complexation: An Interesting Pathway for Combining Two APIs at the Solid State |
title | Complexation: An Interesting Pathway for Combining Two APIs at the Solid State |
title_full | Complexation: An Interesting Pathway for Combining Two APIs at the Solid State |
title_fullStr | Complexation: An Interesting Pathway for Combining Two APIs at the Solid State |
title_full_unstemmed | Complexation: An Interesting Pathway for Combining Two APIs at the Solid State |
title_short | Complexation: An Interesting Pathway for Combining Two APIs at the Solid State |
title_sort | complexation: an interesting pathway for combining two apis at the solid state |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503796/ https://www.ncbi.nlm.nih.gov/pubmed/36145706 http://dx.doi.org/10.3390/pharmaceutics14091960 |
work_keys_str_mv | AT lengfucheng complexationaninterestingpathwayforcombiningtwoapisatthesolidstate AT shemchukoleksii complexationaninterestingpathwayforcombiningtwoapisatthesolidstate AT robeynskoen complexationaninterestingpathwayforcombiningtwoapisatthesolidstate AT leyssenstom complexationaninterestingpathwayforcombiningtwoapisatthesolidstate |