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Complexation: An Interesting Pathway for Combining Two APIs at the Solid State

Combining different drugs into a single crystal form is one of the current challenges in crystal engineering, with the number of reported multi-drug solid forms remaining limited. This paper builds upon an efficient approach to combining Active Pharmaceutical Ingredients (APIs) containing carboxylic...

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Detalles Bibliográficos
Autores principales: Leng, Fucheng, Shemchuk, Oleksii, Robeyns, Koen, Leyssens, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503796/
https://www.ncbi.nlm.nih.gov/pubmed/36145706
http://dx.doi.org/10.3390/pharmaceutics14091960
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author Leng, Fucheng
Shemchuk, Oleksii
Robeyns, Koen
Leyssens, Tom
author_facet Leng, Fucheng
Shemchuk, Oleksii
Robeyns, Koen
Leyssens, Tom
author_sort Leng, Fucheng
collection PubMed
description Combining different drugs into a single crystal form is one of the current challenges in crystal engineering, with the number of reported multi-drug solid forms remaining limited. This paper builds upon an efficient approach to combining Active Pharmaceutical Ingredients (APIs) containing carboxylic groups in their structure with APIs containing pyridine moieties. By transforming the former into their zinc salts, they can be successfully combined with the pyridine-containing APIs. This work highlights the successfulness of this approach, as well as the improvement in the physical properties of the obtained solid forms.
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spelling pubmed-95037962022-09-24 Complexation: An Interesting Pathway for Combining Two APIs at the Solid State Leng, Fucheng Shemchuk, Oleksii Robeyns, Koen Leyssens, Tom Pharmaceutics Article Combining different drugs into a single crystal form is one of the current challenges in crystal engineering, with the number of reported multi-drug solid forms remaining limited. This paper builds upon an efficient approach to combining Active Pharmaceutical Ingredients (APIs) containing carboxylic groups in their structure with APIs containing pyridine moieties. By transforming the former into their zinc salts, they can be successfully combined with the pyridine-containing APIs. This work highlights the successfulness of this approach, as well as the improvement in the physical properties of the obtained solid forms. MDPI 2022-09-16 /pmc/articles/PMC9503796/ /pubmed/36145706 http://dx.doi.org/10.3390/pharmaceutics14091960 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leng, Fucheng
Shemchuk, Oleksii
Robeyns, Koen
Leyssens, Tom
Complexation: An Interesting Pathway for Combining Two APIs at the Solid State
title Complexation: An Interesting Pathway for Combining Two APIs at the Solid State
title_full Complexation: An Interesting Pathway for Combining Two APIs at the Solid State
title_fullStr Complexation: An Interesting Pathway for Combining Two APIs at the Solid State
title_full_unstemmed Complexation: An Interesting Pathway for Combining Two APIs at the Solid State
title_short Complexation: An Interesting Pathway for Combining Two APIs at the Solid State
title_sort complexation: an interesting pathway for combining two apis at the solid state
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503796/
https://www.ncbi.nlm.nih.gov/pubmed/36145706
http://dx.doi.org/10.3390/pharmaceutics14091960
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