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Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure—Preliminary In Vivo Study

Background and Objectives: Conditions such as trauma, burns, sepsis, or acute intoxications have considerable consequences on the endocrine status, causing “sick euthyroid syndrome”. Organophosphate exposure may induce an increase in acetylcholine levels, thus altering the thyroid’s hormonal status....

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Autores principales: Cobilinschi, Cristian, Țincu, Radu, Ungureanu, Raluca, Dumitru, Ioana, Băetu, Alexandru, Isac, Sebastian, Cobilinschi, Claudia Oana, Grințescu, Ioana Marina, Mirea, Liliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503844/
https://www.ncbi.nlm.nih.gov/pubmed/36136476
http://dx.doi.org/10.3390/toxics10090511
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author Cobilinschi, Cristian
Țincu, Radu
Ungureanu, Raluca
Dumitru, Ioana
Băetu, Alexandru
Isac, Sebastian
Cobilinschi, Claudia Oana
Grințescu, Ioana Marina
Mirea, Liliana
author_facet Cobilinschi, Cristian
Țincu, Radu
Ungureanu, Raluca
Dumitru, Ioana
Băetu, Alexandru
Isac, Sebastian
Cobilinschi, Claudia Oana
Grințescu, Ioana Marina
Mirea, Liliana
author_sort Cobilinschi, Cristian
collection PubMed
description Background and Objectives: Conditions such as trauma, burns, sepsis, or acute intoxications have considerable consequences on the endocrine status, causing “sick euthyroid syndrome”. Organophosphate exposure may induce an increase in acetylcholine levels, thus altering the thyroid’s hormonal status. The present study aims to identify the effects of acetylcholinesterase inhibition on thyroid hormones. Material and methods: A prospective experimental study was conducted on twenty Wistar rats. Blood samples were drawn to set baseline values for thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4). Chlorpyrifos 0.1 mg/kg was administered by oral gavage to induce acetyl-cholinesterase inhibition. After exhibiting cholinergic symptoms, blood samples were collected to assess levels of cholinesterase and thyroid hormones using ELISA. Results: Butyrylcholinesterase levels confirmed major inhibition immediately after intoxication compared to the baseline, certifying the intoxication. A significant increase in T4 levels was noted (p = 0.01) both at 2 h and 48 h after administration of organophosphate in sample rats. Similarly, T3 almost doubled its value 2 h after poisoning (4.2 ng/mL versus 2.5 ng/mL at baseline). Surprisingly, TSH displayed acute elevation with an afterward slow descending trend at 48 h (p = 0.1), reaching baseline value. Conclusions: This study demonstrated that cholinesterase inhibition caused major alterations in thyroid hormone levels, which may be characterized by a transient hypothyroidism status with an impact on survival prognosis.
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spelling pubmed-95038442022-09-24 Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure—Preliminary In Vivo Study Cobilinschi, Cristian Țincu, Radu Ungureanu, Raluca Dumitru, Ioana Băetu, Alexandru Isac, Sebastian Cobilinschi, Claudia Oana Grințescu, Ioana Marina Mirea, Liliana Toxics Article Background and Objectives: Conditions such as trauma, burns, sepsis, or acute intoxications have considerable consequences on the endocrine status, causing “sick euthyroid syndrome”. Organophosphate exposure may induce an increase in acetylcholine levels, thus altering the thyroid’s hormonal status. The present study aims to identify the effects of acetylcholinesterase inhibition on thyroid hormones. Material and methods: A prospective experimental study was conducted on twenty Wistar rats. Blood samples were drawn to set baseline values for thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4). Chlorpyrifos 0.1 mg/kg was administered by oral gavage to induce acetyl-cholinesterase inhibition. After exhibiting cholinergic symptoms, blood samples were collected to assess levels of cholinesterase and thyroid hormones using ELISA. Results: Butyrylcholinesterase levels confirmed major inhibition immediately after intoxication compared to the baseline, certifying the intoxication. A significant increase in T4 levels was noted (p = 0.01) both at 2 h and 48 h after administration of organophosphate in sample rats. Similarly, T3 almost doubled its value 2 h after poisoning (4.2 ng/mL versus 2.5 ng/mL at baseline). Surprisingly, TSH displayed acute elevation with an afterward slow descending trend at 48 h (p = 0.1), reaching baseline value. Conclusions: This study demonstrated that cholinesterase inhibition caused major alterations in thyroid hormone levels, which may be characterized by a transient hypothyroidism status with an impact on survival prognosis. MDPI 2022-08-29 /pmc/articles/PMC9503844/ /pubmed/36136476 http://dx.doi.org/10.3390/toxics10090511 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cobilinschi, Cristian
Țincu, Radu
Ungureanu, Raluca
Dumitru, Ioana
Băetu, Alexandru
Isac, Sebastian
Cobilinschi, Claudia Oana
Grințescu, Ioana Marina
Mirea, Liliana
Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure—Preliminary In Vivo Study
title Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure—Preliminary In Vivo Study
title_full Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure—Preliminary In Vivo Study
title_fullStr Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure—Preliminary In Vivo Study
title_full_unstemmed Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure—Preliminary In Vivo Study
title_short Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure—Preliminary In Vivo Study
title_sort toxic-induced nonthyroidal illness syndrome induced by acute low-dose pesticides exposure—preliminary in vivo study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503844/
https://www.ncbi.nlm.nih.gov/pubmed/36136476
http://dx.doi.org/10.3390/toxics10090511
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