Cargando…
Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases
Gut microbiota dysbiosis has recently been reported in a number of clinical states, including neurological, psychiatric, cardiovascular, metabolic and autoimmune disorders. Yet, it is not completely understood how colonizing microorganisms are implicated in their pathophysiology and molecular pathwa...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503867/ https://www.ncbi.nlm.nih.gov/pubmed/36142642 http://dx.doi.org/10.3390/ijms231810729 |
_version_ | 1784796072273510400 |
---|---|
author | Belvoncikova, Paulina Maronek, Martin Gardlik, Roman |
author_facet | Belvoncikova, Paulina Maronek, Martin Gardlik, Roman |
author_sort | Belvoncikova, Paulina |
collection | PubMed |
description | Gut microbiota dysbiosis has recently been reported in a number of clinical states, including neurological, psychiatric, cardiovascular, metabolic and autoimmune disorders. Yet, it is not completely understood how colonizing microorganisms are implicated in their pathophysiology and molecular pathways. There are a number of suggested mechanisms of how gut microbiota dysbiosis triggers or sustains extraintestinal diseases; however, none of these have been widely accepted as part of the disease pathogenesis. Recent studies have proposed that gut microbiota and its metabolites could play a pivotal role in the modulation of immune system responses and the development of autoimmunity in diseases such as rheumatoid arthritis, multiple sclerosis or type 1 diabetes. Fecal microbiota transplantation (FMT) is a valuable tool for uncovering the role of gut microbiota in the pathological processes. This review aims to summarize the current knowledge about gut microbiota dysbiosis and the potential of FMT in studying the pathogeneses and therapies of autoimmune diseases. Herein, we discuss the extraintestinal autoimmune pathologies with at least one published or ongoing FMT study in human or animal models. |
format | Online Article Text |
id | pubmed-9503867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95038672022-09-24 Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases Belvoncikova, Paulina Maronek, Martin Gardlik, Roman Int J Mol Sci Review Gut microbiota dysbiosis has recently been reported in a number of clinical states, including neurological, psychiatric, cardiovascular, metabolic and autoimmune disorders. Yet, it is not completely understood how colonizing microorganisms are implicated in their pathophysiology and molecular pathways. There are a number of suggested mechanisms of how gut microbiota dysbiosis triggers or sustains extraintestinal diseases; however, none of these have been widely accepted as part of the disease pathogenesis. Recent studies have proposed that gut microbiota and its metabolites could play a pivotal role in the modulation of immune system responses and the development of autoimmunity in diseases such as rheumatoid arthritis, multiple sclerosis or type 1 diabetes. Fecal microbiota transplantation (FMT) is a valuable tool for uncovering the role of gut microbiota in the pathological processes. This review aims to summarize the current knowledge about gut microbiota dysbiosis and the potential of FMT in studying the pathogeneses and therapies of autoimmune diseases. Herein, we discuss the extraintestinal autoimmune pathologies with at least one published or ongoing FMT study in human or animal models. MDPI 2022-09-14 /pmc/articles/PMC9503867/ /pubmed/36142642 http://dx.doi.org/10.3390/ijms231810729 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Belvoncikova, Paulina Maronek, Martin Gardlik, Roman Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases |
title | Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases |
title_full | Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases |
title_fullStr | Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases |
title_full_unstemmed | Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases |
title_short | Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases |
title_sort | gut dysbiosis and fecal microbiota transplantation in autoimmune diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503867/ https://www.ncbi.nlm.nih.gov/pubmed/36142642 http://dx.doi.org/10.3390/ijms231810729 |
work_keys_str_mv | AT belvoncikovapaulina gutdysbiosisandfecalmicrobiotatransplantationinautoimmunediseases AT maronekmartin gutdysbiosisandfecalmicrobiotatransplantationinautoimmunediseases AT gardlikroman gutdysbiosisandfecalmicrobiotatransplantationinautoimmunediseases |