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IL-18 Signaling Is Essential for Causing Streptococcal Toxic Shock-like Syndrome (STSLS)

Streptococcus suis (S. suis) is an emerging zoonotic pathogen that can cause multiple diseases, including streptococcal toxic shock-like syndrome (STSLS). The S. suis SC-19 strain could cause NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammasome hyperactivation, then ind...

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Autores principales: Xu, Lei, Zeng, Yue, Gao, Peiying, Lu, Xi, Xia, Kunlong, Zhou, Liting, Zhang, Chengfeng, Yi, Chenyang, Zhang, Anding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503922/
https://www.ncbi.nlm.nih.gov/pubmed/36143361
http://dx.doi.org/10.3390/life12091324
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author Xu, Lei
Zeng, Yue
Gao, Peiying
Lu, Xi
Xia, Kunlong
Zhou, Liting
Zhang, Chengfeng
Yi, Chenyang
Zhang, Anding
author_facet Xu, Lei
Zeng, Yue
Gao, Peiying
Lu, Xi
Xia, Kunlong
Zhou, Liting
Zhang, Chengfeng
Yi, Chenyang
Zhang, Anding
author_sort Xu, Lei
collection PubMed
description Streptococcus suis (S. suis) is an emerging zoonotic pathogen that can cause multiple diseases, including streptococcal toxic shock-like syndrome (STSLS). The S. suis SC-19 strain could cause NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammasome hyperactivation, then induce a cytokine storm and STSLS. Although IL-18 is the downstream effector of NLRP3 signaling, the role of IL-18 signaling on STSLS remains to be elucidated. Thus, il18r1 gene knockout mice were constructed and challenged with the SC-19 strain. Alleviated clinical signs and tissue damages, as well as improved survival were observed in il18r−/− mice compared with the WT mice post-SC-19 challenge. Meanwhile, an obvious decrease in the inflammatory cytokine levels in blood was observed in the il18r-/- mice infected with SC-19. Therefore, IL-18, the downstream effector of NLRP3 inflammasome activation, was responsible for the cytokine storm and STSLS development caused by S. suis, suggesting that IL-18/IL-18Rα signaling could serve as a new target for STSLS.
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spelling pubmed-95039222022-09-24 IL-18 Signaling Is Essential for Causing Streptococcal Toxic Shock-like Syndrome (STSLS) Xu, Lei Zeng, Yue Gao, Peiying Lu, Xi Xia, Kunlong Zhou, Liting Zhang, Chengfeng Yi, Chenyang Zhang, Anding Life (Basel) Communication Streptococcus suis (S. suis) is an emerging zoonotic pathogen that can cause multiple diseases, including streptococcal toxic shock-like syndrome (STSLS). The S. suis SC-19 strain could cause NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammasome hyperactivation, then induce a cytokine storm and STSLS. Although IL-18 is the downstream effector of NLRP3 signaling, the role of IL-18 signaling on STSLS remains to be elucidated. Thus, il18r1 gene knockout mice were constructed and challenged with the SC-19 strain. Alleviated clinical signs and tissue damages, as well as improved survival were observed in il18r−/− mice compared with the WT mice post-SC-19 challenge. Meanwhile, an obvious decrease in the inflammatory cytokine levels in blood was observed in the il18r-/- mice infected with SC-19. Therefore, IL-18, the downstream effector of NLRP3 inflammasome activation, was responsible for the cytokine storm and STSLS development caused by S. suis, suggesting that IL-18/IL-18Rα signaling could serve as a new target for STSLS. MDPI 2022-08-26 /pmc/articles/PMC9503922/ /pubmed/36143361 http://dx.doi.org/10.3390/life12091324 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Xu, Lei
Zeng, Yue
Gao, Peiying
Lu, Xi
Xia, Kunlong
Zhou, Liting
Zhang, Chengfeng
Yi, Chenyang
Zhang, Anding
IL-18 Signaling Is Essential for Causing Streptococcal Toxic Shock-like Syndrome (STSLS)
title IL-18 Signaling Is Essential for Causing Streptococcal Toxic Shock-like Syndrome (STSLS)
title_full IL-18 Signaling Is Essential for Causing Streptococcal Toxic Shock-like Syndrome (STSLS)
title_fullStr IL-18 Signaling Is Essential for Causing Streptococcal Toxic Shock-like Syndrome (STSLS)
title_full_unstemmed IL-18 Signaling Is Essential for Causing Streptococcal Toxic Shock-like Syndrome (STSLS)
title_short IL-18 Signaling Is Essential for Causing Streptococcal Toxic Shock-like Syndrome (STSLS)
title_sort il-18 signaling is essential for causing streptococcal toxic shock-like syndrome (stsls)
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503922/
https://www.ncbi.nlm.nih.gov/pubmed/36143361
http://dx.doi.org/10.3390/life12091324
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