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Development of Parkinsonism in a Patient with Central Pontine Myelinolysis

Osmotic demyelination syndrome (ODS) is caused by damage to the pons myelin sheath and nerve cells. Although the pathophysiological mechanism responsible for the damage is not yet fully understood, it is currently believed that osmotic-type changes (especially if they are massive and too rapid) caus...

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Autores principales: Antonioni, Annibale, Rispoli, Vittorio, Fazio, Patrik, Golfrè Andreasi, Nico, Govoni, Vittorio, Granieri, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503931/
https://www.ncbi.nlm.nih.gov/pubmed/36135990
http://dx.doi.org/10.3390/neurolint14030055
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author Antonioni, Annibale
Rispoli, Vittorio
Fazio, Patrik
Golfrè Andreasi, Nico
Govoni, Vittorio
Granieri, Enrico
author_facet Antonioni, Annibale
Rispoli, Vittorio
Fazio, Patrik
Golfrè Andreasi, Nico
Govoni, Vittorio
Granieri, Enrico
author_sort Antonioni, Annibale
collection PubMed
description Osmotic demyelination syndrome (ODS) is caused by damage to the pons myelin sheath and nerve cells. Although the pathophysiological mechanism responsible for the damage is not yet fully understood, it is currently believed that osmotic-type changes (especially if they are massive and too rapid) cause oedema that leads to compression and, subsequently, demyelination of white matter fibres. It generally manifests with acute paraparesis/tetraparesis, dysphagia, dysarthria, diplopia, and loss of consciousness, as well as hallucinations, spasms, and other neurological symptoms related to brainstem damage. In extreme cases, the locked-in syndrome may also appear. Of note, in some cases an association between osmotic demyelinating damage and the onset of movement disorders has been documented and, although the pathophysiology is still unknown, a correlation has been postulated between ODS and movement disorders. Here, we present a patient with ODS who developed parkinsonism, thus supporting the hypothesis of a correlation between these pathological events.
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spelling pubmed-95039312022-09-24 Development of Parkinsonism in a Patient with Central Pontine Myelinolysis Antonioni, Annibale Rispoli, Vittorio Fazio, Patrik Golfrè Andreasi, Nico Govoni, Vittorio Granieri, Enrico Neurol Int Interesting Images Osmotic demyelination syndrome (ODS) is caused by damage to the pons myelin sheath and nerve cells. Although the pathophysiological mechanism responsible for the damage is not yet fully understood, it is currently believed that osmotic-type changes (especially if they are massive and too rapid) cause oedema that leads to compression and, subsequently, demyelination of white matter fibres. It generally manifests with acute paraparesis/tetraparesis, dysphagia, dysarthria, diplopia, and loss of consciousness, as well as hallucinations, spasms, and other neurological symptoms related to brainstem damage. In extreme cases, the locked-in syndrome may also appear. Of note, in some cases an association between osmotic demyelinating damage and the onset of movement disorders has been documented and, although the pathophysiology is still unknown, a correlation has been postulated between ODS and movement disorders. Here, we present a patient with ODS who developed parkinsonism, thus supporting the hypothesis of a correlation between these pathological events. MDPI 2022-08-25 /pmc/articles/PMC9503931/ /pubmed/36135990 http://dx.doi.org/10.3390/neurolint14030055 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Antonioni, Annibale
Rispoli, Vittorio
Fazio, Patrik
Golfrè Andreasi, Nico
Govoni, Vittorio
Granieri, Enrico
Development of Parkinsonism in a Patient with Central Pontine Myelinolysis
title Development of Parkinsonism in a Patient with Central Pontine Myelinolysis
title_full Development of Parkinsonism in a Patient with Central Pontine Myelinolysis
title_fullStr Development of Parkinsonism in a Patient with Central Pontine Myelinolysis
title_full_unstemmed Development of Parkinsonism in a Patient with Central Pontine Myelinolysis
title_short Development of Parkinsonism in a Patient with Central Pontine Myelinolysis
title_sort development of parkinsonism in a patient with central pontine myelinolysis
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503931/
https://www.ncbi.nlm.nih.gov/pubmed/36135990
http://dx.doi.org/10.3390/neurolint14030055
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