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Development of Parkinsonism in a Patient with Central Pontine Myelinolysis
Osmotic demyelination syndrome (ODS) is caused by damage to the pons myelin sheath and nerve cells. Although the pathophysiological mechanism responsible for the damage is not yet fully understood, it is currently believed that osmotic-type changes (especially if they are massive and too rapid) caus...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503931/ https://www.ncbi.nlm.nih.gov/pubmed/36135990 http://dx.doi.org/10.3390/neurolint14030055 |
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author | Antonioni, Annibale Rispoli, Vittorio Fazio, Patrik Golfrè Andreasi, Nico Govoni, Vittorio Granieri, Enrico |
author_facet | Antonioni, Annibale Rispoli, Vittorio Fazio, Patrik Golfrè Andreasi, Nico Govoni, Vittorio Granieri, Enrico |
author_sort | Antonioni, Annibale |
collection | PubMed |
description | Osmotic demyelination syndrome (ODS) is caused by damage to the pons myelin sheath and nerve cells. Although the pathophysiological mechanism responsible for the damage is not yet fully understood, it is currently believed that osmotic-type changes (especially if they are massive and too rapid) cause oedema that leads to compression and, subsequently, demyelination of white matter fibres. It generally manifests with acute paraparesis/tetraparesis, dysphagia, dysarthria, diplopia, and loss of consciousness, as well as hallucinations, spasms, and other neurological symptoms related to brainstem damage. In extreme cases, the locked-in syndrome may also appear. Of note, in some cases an association between osmotic demyelinating damage and the onset of movement disorders has been documented and, although the pathophysiology is still unknown, a correlation has been postulated between ODS and movement disorders. Here, we present a patient with ODS who developed parkinsonism, thus supporting the hypothesis of a correlation between these pathological events. |
format | Online Article Text |
id | pubmed-9503931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95039312022-09-24 Development of Parkinsonism in a Patient with Central Pontine Myelinolysis Antonioni, Annibale Rispoli, Vittorio Fazio, Patrik Golfrè Andreasi, Nico Govoni, Vittorio Granieri, Enrico Neurol Int Interesting Images Osmotic demyelination syndrome (ODS) is caused by damage to the pons myelin sheath and nerve cells. Although the pathophysiological mechanism responsible for the damage is not yet fully understood, it is currently believed that osmotic-type changes (especially if they are massive and too rapid) cause oedema that leads to compression and, subsequently, demyelination of white matter fibres. It generally manifests with acute paraparesis/tetraparesis, dysphagia, dysarthria, diplopia, and loss of consciousness, as well as hallucinations, spasms, and other neurological symptoms related to brainstem damage. In extreme cases, the locked-in syndrome may also appear. Of note, in some cases an association between osmotic demyelinating damage and the onset of movement disorders has been documented and, although the pathophysiology is still unknown, a correlation has been postulated between ODS and movement disorders. Here, we present a patient with ODS who developed parkinsonism, thus supporting the hypothesis of a correlation between these pathological events. MDPI 2022-08-25 /pmc/articles/PMC9503931/ /pubmed/36135990 http://dx.doi.org/10.3390/neurolint14030055 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Interesting Images Antonioni, Annibale Rispoli, Vittorio Fazio, Patrik Golfrè Andreasi, Nico Govoni, Vittorio Granieri, Enrico Development of Parkinsonism in a Patient with Central Pontine Myelinolysis |
title | Development of Parkinsonism in a Patient with Central Pontine Myelinolysis |
title_full | Development of Parkinsonism in a Patient with Central Pontine Myelinolysis |
title_fullStr | Development of Parkinsonism in a Patient with Central Pontine Myelinolysis |
title_full_unstemmed | Development of Parkinsonism in a Patient with Central Pontine Myelinolysis |
title_short | Development of Parkinsonism in a Patient with Central Pontine Myelinolysis |
title_sort | development of parkinsonism in a patient with central pontine myelinolysis |
topic | Interesting Images |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503931/ https://www.ncbi.nlm.nih.gov/pubmed/36135990 http://dx.doi.org/10.3390/neurolint14030055 |
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