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Effects of Dexamethasone and Pentoxifylline on Mania-like and Depression-like Behaviors in Rats
Several studies support the notion that inflammation plays a role in the pathophysiology and treatment approaches of psychiatric illnesses, particularly mood disorders. Congruently, classic anti-inflammatory drugs were found efficacious in randomized clinical trials of patients with mood disorders....
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503945/ https://www.ncbi.nlm.nih.gov/pubmed/36145284 http://dx.doi.org/10.3390/ph15091063 |
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author | Nassar, Ahmad Azab, Abed N. |
author_facet | Nassar, Ahmad Azab, Abed N. |
author_sort | Nassar, Ahmad |
collection | PubMed |
description | Several studies support the notion that inflammation plays a role in the pathophysiology and treatment approaches of psychiatric illnesses, particularly mood disorders. Congruently, classic anti-inflammatory drugs were found efficacious in randomized clinical trials of patients with mood disorders. Moreover, accumulating data indicate that psychotropic drugs exhibit some anti-inflammatory effects. This study was undertaken to examine the efficacy of dexamethasone (a potent corticosteroid) and pentoxifylline (a methylxanthine drug with proven anti-tumor necrosis factor-α inhibitory activity) in behavioral models in rats, which were treated intraperitoneally with either dexamethasone or pentoxifylline for two weeks and then subjected to a battery of behavioral tests. Treatment with pentoxifylline, but not dexamethasone, was associated with antidepressant-like and anti-manic-like effects. The beneficial behavioral effects of pentoxifylline were accompanied by a prominent reduction in pro-inflammatory mediator levels in the brain. For the first time, the current work proves the efficacy of pentoxifylline against both mania-like and depressive-like behaviors. These results suggest that pentoxifylline may be a promising therapeutic intervention for patients with mood disorders. Taking into account the excellent tolerability profile of pentoxifylline in humans, it is warranted to conduct randomized clinical trials to investigate its therapeutic efficacy in patients with psychiatric disorders. |
format | Online Article Text |
id | pubmed-9503945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95039452022-09-24 Effects of Dexamethasone and Pentoxifylline on Mania-like and Depression-like Behaviors in Rats Nassar, Ahmad Azab, Abed N. Pharmaceuticals (Basel) Article Several studies support the notion that inflammation plays a role in the pathophysiology and treatment approaches of psychiatric illnesses, particularly mood disorders. Congruently, classic anti-inflammatory drugs were found efficacious in randomized clinical trials of patients with mood disorders. Moreover, accumulating data indicate that psychotropic drugs exhibit some anti-inflammatory effects. This study was undertaken to examine the efficacy of dexamethasone (a potent corticosteroid) and pentoxifylline (a methylxanthine drug with proven anti-tumor necrosis factor-α inhibitory activity) in behavioral models in rats, which were treated intraperitoneally with either dexamethasone or pentoxifylline for two weeks and then subjected to a battery of behavioral tests. Treatment with pentoxifylline, but not dexamethasone, was associated with antidepressant-like and anti-manic-like effects. The beneficial behavioral effects of pentoxifylline were accompanied by a prominent reduction in pro-inflammatory mediator levels in the brain. For the first time, the current work proves the efficacy of pentoxifylline against both mania-like and depressive-like behaviors. These results suggest that pentoxifylline may be a promising therapeutic intervention for patients with mood disorders. Taking into account the excellent tolerability profile of pentoxifylline in humans, it is warranted to conduct randomized clinical trials to investigate its therapeutic efficacy in patients with psychiatric disorders. MDPI 2022-08-26 /pmc/articles/PMC9503945/ /pubmed/36145284 http://dx.doi.org/10.3390/ph15091063 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nassar, Ahmad Azab, Abed N. Effects of Dexamethasone and Pentoxifylline on Mania-like and Depression-like Behaviors in Rats |
title | Effects of Dexamethasone and Pentoxifylline on Mania-like and Depression-like Behaviors in Rats |
title_full | Effects of Dexamethasone and Pentoxifylline on Mania-like and Depression-like Behaviors in Rats |
title_fullStr | Effects of Dexamethasone and Pentoxifylline on Mania-like and Depression-like Behaviors in Rats |
title_full_unstemmed | Effects of Dexamethasone and Pentoxifylline on Mania-like and Depression-like Behaviors in Rats |
title_short | Effects of Dexamethasone and Pentoxifylline on Mania-like and Depression-like Behaviors in Rats |
title_sort | effects of dexamethasone and pentoxifylline on mania-like and depression-like behaviors in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503945/ https://www.ncbi.nlm.nih.gov/pubmed/36145284 http://dx.doi.org/10.3390/ph15091063 |
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