Sinonasal Meningioma in a Siberian Tiger (Panthera tigris altaica)

SIMPLE SUMMARY: Meningiomas are the most common primary brain tumour in dogs and cats. However, whilst there are numerous reports of meningiomas at extracranial sites in the dog (such as the spine, the eye and near the nasal cavity), in cats there have only been a few case reports of meningiomas arising in the spine, and no reports of post-mortem confirmed meningiomas arising in the eyes or near the nasal cavity. In this report, a 20-year-old captive tiger (Panthera tigris altaica) with a history of chronic eye inflammation, resulting in eventual removal of the eye, spontaneously developed epilepsy. Over the course of 2 years, the seizures worsened to the point where the animal was eventually euthanized. At autopsy, a mass was found near the nasal cavity and histological analysis showed tumour cells surrounded by a collagenous matrix. The diagnosis was sinonasal transitional meningioma. This is the first report of a captive wild felid with an extracranial meningioma, specifically a tiger with a sinonasal transitional meningioma. ABSTRACT: Meningiomas are the most common primary brain tumour in dogs and cats. However, whilst there are numerous reports of extracranial (spinal, orbital and sinonasal) meningiomas in the dog, there have only been a few case reports of spinal meningiomas, and no post-mortem confirmed orbital or sinonasal meningiomas in cats. In this report, a 20-year-old captive tiger (Panthera tigris altaica) with a history of chronic ocular inflammation resulting in enucleation, spontaneously developed tetanic convulsions (epileptic seizures) that over a 2-year period resulted in a gradually worsening condition and the animal was eventually euthanized. At autopsy, a focal, expansile, neoplastic mass was found in the caudal nasal cavity midline, abutting the cribriform plate and slightly compressing the calvarium. Histological analysis revealed nasal turbinates attached to a well-circumscribed expansile multi-lobular mass consisting of interlacing whorls and streams of neoplastic cells supported by a variably fibrous to microcystic collagenous matrix displaying rare psammoma bodies. The diagnosis was sinonasal transitional meningioma. This is the first report of a captive wild felid with an extracranial meningioma, specifically a tiger with a sinonasal transitional meningioma.