Cargando…

Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration

Progressive loss and dysfunction of islet β-cells has not yet been solved in the treatment of diabetes. Regenerating protein (Reg) has been identified as a trophic factor which is demonstrated to be associated with pancreatic tissue regeneration. We previously produced recombinant Reg3α protein (rRe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Luting, Li, Liang, Liu, Junli, Sun, Hao, Li, Xiang, Xiao, Hanyu, Alfred, Martin Omondi, Wang, Min, Wu, Xuri, Gao, Yan, Luo, Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504149/ https://www.ncbi.nlm.nih.gov/pubmed/36142497 http://dx.doi.org/10.3390/ijms231810584

Ejemplares similares

Recombinant Reg3β protein protects against streptozotocin-induced β-cell damage and diabetes
por: Luo, Chen, et al.
Publicado: (2016)

Regeneration of islet β‐cells in tree shrews and rats
por: Zhao, Yu‐Qiong, et al.
Publicado: (2018)

Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice
por: Shindo, Ryodai, et al.
Publicado: (2020)

Mangiferin Facilitates Islet Regeneration and β-Cell Proliferation through Upregulation of Cell Cycle and β-Cell Regeneration Regulators
por: Wang, Hai-Lian, et al.
Publicado: (2014)

Synergistic Activations of REG Iα and REG I β Promoters by IL-6 and Glucocorticoids through JAK/STAT Pathway in Human Pancreatic β Cells
por: Yamauchi, Akiyo, et al.
Publicado: (2015)

Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic
por: Jones, Edwin C., et al.
Publicado: (2018)

Distinct Cell Clusters Touching Islet Cells Induce Islet Cell Replication in Association with Over-Expression of Regenerating Gene (REG) Protein in Fulminant Type 1 Diabetes
por: Aida, Kaoru, et al.
Publicado: (2014)

Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges
por: Chen, Zijing, et al.
Publicado: (2019)

Unique Arrangement of α- and β-Cells in Human Islets of Langerhans
por: Bosco, Domenico, et al.
Publicado: (2010)

Correction: Distinct Cell Clusters Touching Islet Cells Induce Islet Cell Replication in Association with Over-Expression of Regenerating Gene (REG) Protein in Fulminant Type 1 Diabetes
Publicado: (2014)

DNase I aggravates islet β-cell apoptosis in type 2 diabetes
por: ZHU, BIN, et al.
Publicado: (2016)

Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration
por: Saunders, Diane C., et al.
Publicado: (2021)

IGFBP1 increases β‐cell regeneration by promoting α‐ to β‐cell transdifferentiation
por: Lu, Jing, et al.
Publicado: (2016)

Genetic modulation of islet β-cell iPLA(2)β expression provides evidence for its impact on β-cell apoptosis and autophagy
por: Lei, Xiaoyong, et al.
Publicado: (2013)

Assessment of β-Cell Mass and α- and β-Cell Survival and Function by Arginine Stimulation in Human Autologous Islet Recipients
por: Robertson, R. Paul, et al.
Publicado: (2015)

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo
por: Matsuoka, Taka-aki, et al.
Publicado: (2017)

Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival
por: Hayes, Heather L., et al.
Publicado: (2017)

Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice
por: Petrovic, Ivica, et al.
Publicado: (2020)

Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation
por: Narayanan, Siddharth, et al.
Publicado: (2017)

Pax4 Gene Delivery Improves Islet Transplantation Efficacy by Promoting β Cell Survival and α-to-β Cell Transdifferentiation
por: Parajuli, Keshab R., et al.
Publicado: (2020)

Expression of Mesenchymal and α-Cell Phenotypic Markers in Islet β-Cells in Recently Diagnosed Diabetes
por: White, Michael G., et al.
Publicado: (2013)

Cell Heterogeneity and Paracrine Interactions in Human Islet Function: A Perspective Focused in β-Cell Regeneration Strategies
por: Bru-Tari, Eva, et al.
Publicado: (2021)

Synergism of TNF-α and IFN-β triggers human airway epithelial cells death by apoptosis and pyroptosis
por: Sun, Rui, et al.
Publicado: (2023)

Islet cell plasticity and regeneration()
por: Migliorini, Adriana, et al.
Publicado: (2014)

INTRANUCLEAR RODS IN PANCREATIC ISLET β-CELLS
por: Boquist, Lennart
Publicado: (1969)

Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity
por: Liu, Yue, et al.
Publicado: (2023)

Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets
por: Aldous, Noura, et al.
Publicado: (2023)

Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest
por: Mellado-Gil, Jose Manuel, et al.
Publicado: (2012)

Vitamin B12-Induced Autophagy Alleviates High Glucose-Mediated Apoptosis of Islet β Cells
por: Zhang, Yu, et al.
Publicado: (2023)

REG3β modifies cell tumor function by impairing extracellular vesicle uptake
por: Bonjoch, Laia, et al.
Publicado: (2017)

MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy
por: Zhao, Tongjian, et al.
Publicado: (2020)

Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor
por: Hunter, Chad S., et al.
Publicado: (2013)

REG3β contributes to the immunosuppressive microenvironment of pancreatic cancer
por: Folch-Puy, Emma
Publicado: (2013)

MicroRNA-18 promotes apoptosis of islet β-cells via targeting NAV1
por: Fei, Honghua, et al.
Publicado: (2019)

Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity
por: QiNan, Wu, et al.
Publicado: (2016)

TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity
por: Sun, Xiang, et al.
Publicado: (2019)

Disturbed α-Cell Function in Mice with β-Cell Specific Overexpression of Human Islet Amyloid Polypeptide
por: Ahrén, Bo, et al.
Publicado: (2008)

Single-cell imaging of α and β cell metabolic response to glucose in living human Langerhans islets
por: Azzarello, Fabio, et al.
Publicado: (2022)

Dynamic pathology of islet endocrine cells in type 2 diabetes: β‐Cell growth, death, regeneration and their clinical implications
por: Yagihashi, Soroku, et al.
Publicado: (2015)

Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor
por: Zheng, Meiling, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uph18bjgk0l5i44umv3j634lcg