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Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
The reductionist concept, based on the ligand–receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in many conditions. This review, for the first time...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504187/ https://www.ncbi.nlm.nih.gov/pubmed/36145272 http://dx.doi.org/10.3390/ph15091051 |
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author | Panossian, Alexander Efferth, Thomas |
author_facet | Panossian, Alexander Efferth, Thomas |
author_sort | Panossian, Alexander |
collection | PubMed |
description | The reductionist concept, based on the ligand–receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in many conditions. This review, for the first time, provides a rationale for the pleiotropic therapeutic efficacy of adaptogens based on evidence from recent gene expression studies in target cells and where the network pharmacology and systems biology approaches were applied. The specific molecular targets and adaptive stress response signaling mechanisms involved in nonspecific modes of action of adaptogens are identified. |
format | Online Article Text |
id | pubmed-9504187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95041872022-09-24 Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity Panossian, Alexander Efferth, Thomas Pharmaceuticals (Basel) Review The reductionist concept, based on the ligand–receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in many conditions. This review, for the first time, provides a rationale for the pleiotropic therapeutic efficacy of adaptogens based on evidence from recent gene expression studies in target cells and where the network pharmacology and systems biology approaches were applied. The specific molecular targets and adaptive stress response signaling mechanisms involved in nonspecific modes of action of adaptogens are identified. MDPI 2022-08-25 /pmc/articles/PMC9504187/ /pubmed/36145272 http://dx.doi.org/10.3390/ph15091051 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Panossian, Alexander Efferth, Thomas Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity |
title | Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity |
title_full | Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity |
title_fullStr | Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity |
title_full_unstemmed | Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity |
title_short | Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity |
title_sort | network pharmacology of adaptogens in the assessment of their pleiotropic therapeutic activity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504187/ https://www.ncbi.nlm.nih.gov/pubmed/36145272 http://dx.doi.org/10.3390/ph15091051 |
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