Cargando…

Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity

The reductionist concept, based on the ligand–receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in many conditions. This review, for the first time...

Descripción completa

Detalles Bibliográficos
Autores principales: Panossian, Alexander, Efferth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504187/
https://www.ncbi.nlm.nih.gov/pubmed/36145272
http://dx.doi.org/10.3390/ph15091051
_version_ 1784796152737038336
author Panossian, Alexander
Efferth, Thomas
author_facet Panossian, Alexander
Efferth, Thomas
author_sort Panossian, Alexander
collection PubMed
description The reductionist concept, based on the ligand–receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in many conditions. This review, for the first time, provides a rationale for the pleiotropic therapeutic efficacy of adaptogens based on evidence from recent gene expression studies in target cells and where the network pharmacology and systems biology approaches were applied. The specific molecular targets and adaptive stress response signaling mechanisms involved in nonspecific modes of action of adaptogens are identified.
format Online
Article
Text
id pubmed-9504187
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95041872022-09-24 Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity Panossian, Alexander Efferth, Thomas Pharmaceuticals (Basel) Review The reductionist concept, based on the ligand–receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in many conditions. This review, for the first time, provides a rationale for the pleiotropic therapeutic efficacy of adaptogens based on evidence from recent gene expression studies in target cells and where the network pharmacology and systems biology approaches were applied. The specific molecular targets and adaptive stress response signaling mechanisms involved in nonspecific modes of action of adaptogens are identified. MDPI 2022-08-25 /pmc/articles/PMC9504187/ /pubmed/36145272 http://dx.doi.org/10.3390/ph15091051 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Panossian, Alexander
Efferth, Thomas
Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
title Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
title_full Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
title_fullStr Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
title_full_unstemmed Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
title_short Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
title_sort network pharmacology of adaptogens in the assessment of their pleiotropic therapeutic activity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504187/
https://www.ncbi.nlm.nih.gov/pubmed/36145272
http://dx.doi.org/10.3390/ph15091051
work_keys_str_mv AT panossianalexander networkpharmacologyofadaptogensintheassessmentoftheirpleiotropictherapeuticactivity
AT efferththomas networkpharmacologyofadaptogensintheassessmentoftheirpleiotropictherapeuticactivity