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Formulation of a Gastroretentive In Situ Oral Gel Containing Metformin HCl Based on DoE

A gastroretentive in situ oral gel containing metformin hydrochloride (Met HCl) was prepared based on sodium alginate (Sod ALG), calcium carbonate, and hydroxyethylcellulose (HEC). The optimal composition of the formulation was explored based on the design of experiments (DoE). First, a 3(2) full fa...

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Detalles Bibliográficos
Autores principales:	Kim, Jong Hee, Song, Seung Hyun, Joo, Sang Hoon, Park, Gyu Hwan, Weon, Kwon-Yeon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504191/ https://www.ncbi.nlm.nih.gov/pubmed/36145525 http://dx.doi.org/10.3390/pharmaceutics14091777

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