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Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis

Current efforts to find novel treatments that counteract multiple sclerosis (MS) have pointed toward immunomodulation and remyelination. Currently, cell therapy has shown promising potential to achieve this purpose. However, disadvantages such as poor survival, differentiation, and integration into...

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Autores principales: Ojeda-Hernández, Doddy Denise, Hernández-Sapiéns, Mercedes A., Reza-Zaldívar, Edwin E., Canales-Aguirre, Alejandro, Matías-Guiu, Jordi A., Matías-Guiu, Jorge, Mateos-Díaz, Juan Carlos, Gómez-Pinedo, Ulises, Sancho-Bielsa, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504193/
https://www.ncbi.nlm.nih.gov/pubmed/36143453
http://dx.doi.org/10.3390/life12091417
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author Ojeda-Hernández, Doddy Denise
Hernández-Sapiéns, Mercedes A.
Reza-Zaldívar, Edwin E.
Canales-Aguirre, Alejandro
Matías-Guiu, Jordi A.
Matías-Guiu, Jorge
Mateos-Díaz, Juan Carlos
Gómez-Pinedo, Ulises
Sancho-Bielsa, Francisco
author_facet Ojeda-Hernández, Doddy Denise
Hernández-Sapiéns, Mercedes A.
Reza-Zaldívar, Edwin E.
Canales-Aguirre, Alejandro
Matías-Guiu, Jordi A.
Matías-Guiu, Jorge
Mateos-Díaz, Juan Carlos
Gómez-Pinedo, Ulises
Sancho-Bielsa, Francisco
author_sort Ojeda-Hernández, Doddy Denise
collection PubMed
description Current efforts to find novel treatments that counteract multiple sclerosis (MS) have pointed toward immunomodulation and remyelination. Currently, cell therapy has shown promising potential to achieve this purpose. However, disadvantages such as poor survival, differentiation, and integration into the target tissue have limited its application. A series of recent studies have focused on the cell secretome, showing it to provide the most benefits of cell therapy. Exosomes are a key component of the cell secretome, participating in the transfer of bioactive molecules. These nano-sized vesicles offer many therapeutical advantages, such as the capacity to cross the blood-brain barrier, an enrichable cargo, and a customizable membrane. Moreover, integrating of biomaterials into exosome therapy could lead to new tissue-specific therapeutic strategies. In this work, the use of exosomes and their integration with biomaterials is presented as a novel strategy in the treatment of MS.
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spelling pubmed-95041932022-09-24 Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis Ojeda-Hernández, Doddy Denise Hernández-Sapiéns, Mercedes A. Reza-Zaldívar, Edwin E. Canales-Aguirre, Alejandro Matías-Guiu, Jordi A. Matías-Guiu, Jorge Mateos-Díaz, Juan Carlos Gómez-Pinedo, Ulises Sancho-Bielsa, Francisco Life (Basel) Review Current efforts to find novel treatments that counteract multiple sclerosis (MS) have pointed toward immunomodulation and remyelination. Currently, cell therapy has shown promising potential to achieve this purpose. However, disadvantages such as poor survival, differentiation, and integration into the target tissue have limited its application. A series of recent studies have focused on the cell secretome, showing it to provide the most benefits of cell therapy. Exosomes are a key component of the cell secretome, participating in the transfer of bioactive molecules. These nano-sized vesicles offer many therapeutical advantages, such as the capacity to cross the blood-brain barrier, an enrichable cargo, and a customizable membrane. Moreover, integrating of biomaterials into exosome therapy could lead to new tissue-specific therapeutic strategies. In this work, the use of exosomes and their integration with biomaterials is presented as a novel strategy in the treatment of MS. MDPI 2022-09-11 /pmc/articles/PMC9504193/ /pubmed/36143453 http://dx.doi.org/10.3390/life12091417 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ojeda-Hernández, Doddy Denise
Hernández-Sapiéns, Mercedes A.
Reza-Zaldívar, Edwin E.
Canales-Aguirre, Alejandro
Matías-Guiu, Jordi A.
Matías-Guiu, Jorge
Mateos-Díaz, Juan Carlos
Gómez-Pinedo, Ulises
Sancho-Bielsa, Francisco
Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis
title Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis
title_full Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis
title_fullStr Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis
title_full_unstemmed Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis
title_short Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis
title_sort exosomes and biomaterials: in search of a new therapeutic strategy for multiple sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504193/
https://www.ncbi.nlm.nih.gov/pubmed/36143453
http://dx.doi.org/10.3390/life12091417
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