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Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France

Wild animals may act as efficient antimicrobial-resistance reservoirs and epidemiological links between humans, livestock, and natural environments. By using phenotypic and genotypic characterization, the present study highlighted the occurrence of an antimicrobial-resistant (i.e., amoxicillin, amox...

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Autores principales: Laidoudi, Younes, Ngaiganam, Edgarthe Priscilla, Marié, Jean-Lou, Pagnier, Isabelle, Rolain, Jean-Marc, Mouhamadou Diene, Seydina, Davoust, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504195/
https://www.ncbi.nlm.nih.gov/pubmed/36145454
http://dx.doi.org/10.3390/pathogens11091022
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author Laidoudi, Younes
Ngaiganam, Edgarthe Priscilla
Marié, Jean-Lou
Pagnier, Isabelle
Rolain, Jean-Marc
Mouhamadou Diene, Seydina
Davoust, Bernard
author_facet Laidoudi, Younes
Ngaiganam, Edgarthe Priscilla
Marié, Jean-Lou
Pagnier, Isabelle
Rolain, Jean-Marc
Mouhamadou Diene, Seydina
Davoust, Bernard
author_sort Laidoudi, Younes
collection PubMed
description Wild animals may act as efficient antimicrobial-resistance reservoirs and epidemiological links between humans, livestock, and natural environments. By using phenotypic and genotypic characterization, the present study highlighted the occurrence of an antimicrobial-resistant (i.e., amoxicillin, amoxicillin–clavulanic acid, cephalothin, and colistin) Enterobacter hormaechei subsp. steigerwaltii strain in wild boar (Sus scrofa) from France. The molecular analysis conducted showed non-synonymous mutations in the pmrA/pmrB and phoQ/phoP operons and the phoP/Q regulator mgrB gene, leading to colistin resistance. The present data highlight the need for continuous monitoring of multidrug-resistant bacteria in wild animals to limit the spread of these threatening pathogens.
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spelling pubmed-95041952022-09-24 Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France Laidoudi, Younes Ngaiganam, Edgarthe Priscilla Marié, Jean-Lou Pagnier, Isabelle Rolain, Jean-Marc Mouhamadou Diene, Seydina Davoust, Bernard Pathogens Article Wild animals may act as efficient antimicrobial-resistance reservoirs and epidemiological links between humans, livestock, and natural environments. By using phenotypic and genotypic characterization, the present study highlighted the occurrence of an antimicrobial-resistant (i.e., amoxicillin, amoxicillin–clavulanic acid, cephalothin, and colistin) Enterobacter hormaechei subsp. steigerwaltii strain in wild boar (Sus scrofa) from France. The molecular analysis conducted showed non-synonymous mutations in the pmrA/pmrB and phoQ/phoP operons and the phoP/Q regulator mgrB gene, leading to colistin resistance. The present data highlight the need for continuous monitoring of multidrug-resistant bacteria in wild animals to limit the spread of these threatening pathogens. MDPI 2022-09-07 /pmc/articles/PMC9504195/ /pubmed/36145454 http://dx.doi.org/10.3390/pathogens11091022 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Laidoudi, Younes
Ngaiganam, Edgarthe Priscilla
Marié, Jean-Lou
Pagnier, Isabelle
Rolain, Jean-Marc
Mouhamadou Diene, Seydina
Davoust, Bernard
Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France
title Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France
title_full Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France
title_fullStr Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France
title_full_unstemmed Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France
title_short Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France
title_sort colistin resistance mechanism in enterobacter hormaechei subsp. steigerwaltii isolated from wild boar (sus scrofa) in france
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504195/
https://www.ncbi.nlm.nih.gov/pubmed/36145454
http://dx.doi.org/10.3390/pathogens11091022
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