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Steps towards a Multiple Myeloma Cure?

Multiple myeloma survival has increased in last 20 years because of new treatments, better clinical management due to novel diagnostic tools such as imaging, and better understanding of the disease, biologically and genetically. Novel drugs have been introduced that act with different therapeutic me...

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Detalles Bibliográficos
Autores principales: Gozzetti, Alessandro, Bocchia, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504254/
https://www.ncbi.nlm.nih.gov/pubmed/36143236
http://dx.doi.org/10.3390/jpm12091451
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author Gozzetti, Alessandro
Bocchia, Monica
author_facet Gozzetti, Alessandro
Bocchia, Monica
author_sort Gozzetti, Alessandro
collection PubMed
description Multiple myeloma survival has increased in last 20 years because of new treatments, better clinical management due to novel diagnostic tools such as imaging, and better understanding of the disease, biologically and genetically. Novel drugs have been introduced that act with different therapeutic mechanisms, but so have novel therapeutic strategies such as consolidation and maintenance after autologous stem cell transplant. Imaging (such as PET-CT and MRI) has been applied at diagnosis and after therapy for minimal residual disease monitoring. Multiparametric flow and molecular NGS may detect, with high-sensitivity, residual monoclonal plasma cells in the bone marrow. With this novel therapeutic and biological approach, a considerable fraction of multiple myeloma patients can achieve durable remission or even MGUS-like regression, which can ultimately lead to disease disappearance. The big dogma, “Myeloma is an incurable disease”, is hopefully fading.
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spelling pubmed-95042542022-09-24 Steps towards a Multiple Myeloma Cure? Gozzetti, Alessandro Bocchia, Monica J Pers Med Perspective Multiple myeloma survival has increased in last 20 years because of new treatments, better clinical management due to novel diagnostic tools such as imaging, and better understanding of the disease, biologically and genetically. Novel drugs have been introduced that act with different therapeutic mechanisms, but so have novel therapeutic strategies such as consolidation and maintenance after autologous stem cell transplant. Imaging (such as PET-CT and MRI) has been applied at diagnosis and after therapy for minimal residual disease monitoring. Multiparametric flow and molecular NGS may detect, with high-sensitivity, residual monoclonal plasma cells in the bone marrow. With this novel therapeutic and biological approach, a considerable fraction of multiple myeloma patients can achieve durable remission or even MGUS-like regression, which can ultimately lead to disease disappearance. The big dogma, “Myeloma is an incurable disease”, is hopefully fading. MDPI 2022-09-03 /pmc/articles/PMC9504254/ /pubmed/36143236 http://dx.doi.org/10.3390/jpm12091451 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Gozzetti, Alessandro
Bocchia, Monica
Steps towards a Multiple Myeloma Cure?
title Steps towards a Multiple Myeloma Cure?
title_full Steps towards a Multiple Myeloma Cure?
title_fullStr Steps towards a Multiple Myeloma Cure?
title_full_unstemmed Steps towards a Multiple Myeloma Cure?
title_short Steps towards a Multiple Myeloma Cure?
title_sort steps towards a multiple myeloma cure?
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504254/
https://www.ncbi.nlm.nih.gov/pubmed/36143236
http://dx.doi.org/10.3390/jpm12091451
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