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Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies

The colonization of Helicobacter pylori (H. pylori) in human gastric mucosa is highly associated with the occurrence of gastritis, peptic ulcer, and gastric cancer. Antibiotics, including amoxicillin, clarithromycin, furazolidone, levofloxacin, metronidazole, and tetracycline, are commonly used and...

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Detalles Bibliográficos
Autores principales: Zeng, Judeng, Xie, Chuan, Zhang, Lin, Liu, Xiaodong, Chan, Matthew Tak Vai, Wu, William Ka Kei, Chen, Huarong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504325/
https://www.ncbi.nlm.nih.gov/pubmed/36142852
http://dx.doi.org/10.3390/ijms231810941
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author Zeng, Judeng
Xie, Chuan
Zhang, Lin
Liu, Xiaodong
Chan, Matthew Tak Vai
Wu, William Ka Kei
Chen, Huarong
author_facet Zeng, Judeng
Xie, Chuan
Zhang, Lin
Liu, Xiaodong
Chan, Matthew Tak Vai
Wu, William Ka Kei
Chen, Huarong
author_sort Zeng, Judeng
collection PubMed
description The colonization of Helicobacter pylori (H. pylori) in human gastric mucosa is highly associated with the occurrence of gastritis, peptic ulcer, and gastric cancer. Antibiotics, including amoxicillin, clarithromycin, furazolidone, levofloxacin, metronidazole, and tetracycline, are commonly used and considered the major treatment regimens for H. pylori eradication, which is, however, becoming less effective by the increasing prevalence of H pylori resistance. Thus, it is urgent to understand the molecular mechanisms of H. pylori pathogenesis and develop alternative therapeutic strategies. In this review, we focus on the virulence factors for H. pylori colonization and survival within host gastric mucosa and the host antimicrobial responses against H. pylori infection. Moreover, we describe the current treatments for H. pylori eradication and provide some insights into new therapeutic strategies for H. pylori infection.
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spelling pubmed-95043252022-09-24 Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies Zeng, Judeng Xie, Chuan Zhang, Lin Liu, Xiaodong Chan, Matthew Tak Vai Wu, William Ka Kei Chen, Huarong Int J Mol Sci Review The colonization of Helicobacter pylori (H. pylori) in human gastric mucosa is highly associated with the occurrence of gastritis, peptic ulcer, and gastric cancer. Antibiotics, including amoxicillin, clarithromycin, furazolidone, levofloxacin, metronidazole, and tetracycline, are commonly used and considered the major treatment regimens for H. pylori eradication, which is, however, becoming less effective by the increasing prevalence of H pylori resistance. Thus, it is urgent to understand the molecular mechanisms of H. pylori pathogenesis and develop alternative therapeutic strategies. In this review, we focus on the virulence factors for H. pylori colonization and survival within host gastric mucosa and the host antimicrobial responses against H. pylori infection. Moreover, we describe the current treatments for H. pylori eradication and provide some insights into new therapeutic strategies for H. pylori infection. MDPI 2022-09-19 /pmc/articles/PMC9504325/ /pubmed/36142852 http://dx.doi.org/10.3390/ijms231810941 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zeng, Judeng
Xie, Chuan
Zhang, Lin
Liu, Xiaodong
Chan, Matthew Tak Vai
Wu, William Ka Kei
Chen, Huarong
Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies
title Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies
title_full Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies
title_fullStr Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies
title_full_unstemmed Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies
title_short Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies
title_sort host cell antimicrobial responses against helicobacter pylori infection: from biological aspects to therapeutic strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504325/
https://www.ncbi.nlm.nih.gov/pubmed/36142852
http://dx.doi.org/10.3390/ijms231810941
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