Cargando…
Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies
The colonization of Helicobacter pylori (H. pylori) in human gastric mucosa is highly associated with the occurrence of gastritis, peptic ulcer, and gastric cancer. Antibiotics, including amoxicillin, clarithromycin, furazolidone, levofloxacin, metronidazole, and tetracycline, are commonly used and...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504325/ https://www.ncbi.nlm.nih.gov/pubmed/36142852 http://dx.doi.org/10.3390/ijms231810941 |
_version_ | 1784796187350532096 |
---|---|
author | Zeng, Judeng Xie, Chuan Zhang, Lin Liu, Xiaodong Chan, Matthew Tak Vai Wu, William Ka Kei Chen, Huarong |
author_facet | Zeng, Judeng Xie, Chuan Zhang, Lin Liu, Xiaodong Chan, Matthew Tak Vai Wu, William Ka Kei Chen, Huarong |
author_sort | Zeng, Judeng |
collection | PubMed |
description | The colonization of Helicobacter pylori (H. pylori) in human gastric mucosa is highly associated with the occurrence of gastritis, peptic ulcer, and gastric cancer. Antibiotics, including amoxicillin, clarithromycin, furazolidone, levofloxacin, metronidazole, and tetracycline, are commonly used and considered the major treatment regimens for H. pylori eradication, which is, however, becoming less effective by the increasing prevalence of H pylori resistance. Thus, it is urgent to understand the molecular mechanisms of H. pylori pathogenesis and develop alternative therapeutic strategies. In this review, we focus on the virulence factors for H. pylori colonization and survival within host gastric mucosa and the host antimicrobial responses against H. pylori infection. Moreover, we describe the current treatments for H. pylori eradication and provide some insights into new therapeutic strategies for H. pylori infection. |
format | Online Article Text |
id | pubmed-9504325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95043252022-09-24 Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies Zeng, Judeng Xie, Chuan Zhang, Lin Liu, Xiaodong Chan, Matthew Tak Vai Wu, William Ka Kei Chen, Huarong Int J Mol Sci Review The colonization of Helicobacter pylori (H. pylori) in human gastric mucosa is highly associated with the occurrence of gastritis, peptic ulcer, and gastric cancer. Antibiotics, including amoxicillin, clarithromycin, furazolidone, levofloxacin, metronidazole, and tetracycline, are commonly used and considered the major treatment regimens for H. pylori eradication, which is, however, becoming less effective by the increasing prevalence of H pylori resistance. Thus, it is urgent to understand the molecular mechanisms of H. pylori pathogenesis and develop alternative therapeutic strategies. In this review, we focus on the virulence factors for H. pylori colonization and survival within host gastric mucosa and the host antimicrobial responses against H. pylori infection. Moreover, we describe the current treatments for H. pylori eradication and provide some insights into new therapeutic strategies for H. pylori infection. MDPI 2022-09-19 /pmc/articles/PMC9504325/ /pubmed/36142852 http://dx.doi.org/10.3390/ijms231810941 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zeng, Judeng Xie, Chuan Zhang, Lin Liu, Xiaodong Chan, Matthew Tak Vai Wu, William Ka Kei Chen, Huarong Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies |
title | Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies |
title_full | Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies |
title_fullStr | Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies |
title_full_unstemmed | Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies |
title_short | Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies |
title_sort | host cell antimicrobial responses against helicobacter pylori infection: from biological aspects to therapeutic strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504325/ https://www.ncbi.nlm.nih.gov/pubmed/36142852 http://dx.doi.org/10.3390/ijms231810941 |
work_keys_str_mv | AT zengjudeng hostcellantimicrobialresponsesagainsthelicobacterpyloriinfectionfrombiologicalaspectstotherapeuticstrategies AT xiechuan hostcellantimicrobialresponsesagainsthelicobacterpyloriinfectionfrombiologicalaspectstotherapeuticstrategies AT zhanglin hostcellantimicrobialresponsesagainsthelicobacterpyloriinfectionfrombiologicalaspectstotherapeuticstrategies AT liuxiaodong hostcellantimicrobialresponsesagainsthelicobacterpyloriinfectionfrombiologicalaspectstotherapeuticstrategies AT chanmatthewtakvai hostcellantimicrobialresponsesagainsthelicobacterpyloriinfectionfrombiologicalaspectstotherapeuticstrategies AT wuwilliamkakei hostcellantimicrobialresponsesagainsthelicobacterpyloriinfectionfrombiologicalaspectstotherapeuticstrategies AT chenhuarong hostcellantimicrobialresponsesagainsthelicobacterpyloriinfectionfrombiologicalaspectstotherapeuticstrategies |