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Prevalence of Escherichia coli ST1193 Causing Intracranial Infection in Changsha, China

ST1193 is an emerging new virulent and resistant clone among Escherichia coli with a tendency to spread rapidly across the globe. However, the prevalence of intracranial infection-causing E. coli ST1193 is rarely reported. This study aimed at determining the prevalence of E. coli ST1193 isolates, ca...

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Autores principales: Zhong, Yi-Ming, Zhang, Xiao-He, Ma, Zheng, Liu, Wen-En
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504535/
https://www.ncbi.nlm.nih.gov/pubmed/36136628
http://dx.doi.org/10.3390/tropicalmed7090217
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author Zhong, Yi-Ming
Zhang, Xiao-He
Ma, Zheng
Liu, Wen-En
author_facet Zhong, Yi-Ming
Zhang, Xiao-He
Ma, Zheng
Liu, Wen-En
author_sort Zhong, Yi-Ming
collection PubMed
description ST1193 is an emerging new virulent and resistant clone among Escherichia coli with a tendency to spread rapidly across the globe. However, the prevalence of intracranial infection-causing E. coli ST1193 is rarely reported. This study aimed at determining the prevalence of E. coli ST1193 isolates, causing intracranial infections in Changsha, central China. A total of 28 E. coli isolates were collected from the cerebrospinal fluid of patients with intracranial infection over a four-year period. All isolates were differentiated using multilocus sequence typing (MLST), and phylogenetic grouping, and tested for antibiotic resistance. MLST analysis showed 11 sequence types (ST) among the 28 E. coli isolates. The most prevalent ST was B2-ST1193 (28.6%, 8/28), followed by B2-ST131 (21.4%, 6/28) and F-ST648 (10.7%, 3/28). Of the eight ST1193 isolates, three carried CTX-M-55, and one carried CTX-M-27. All eight ST1193 isolates were resistant to Ciprofloxacin, showing gyrA1AB/parC4A mutations. Two ST1193 isolates carried the aac(6′)-Ib-cr gene. All ST1193 isolates were recovered from infants with meningitis, with a fatal outcome for one three-month-old infant. ST1193 has emerged as the predominant type of E. coli strain causing intracranial infections in Changsha, China. This study highlights the importance of implementing appropriate surveillance measures to prevent the spread of this emerging public health threat.
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spelling pubmed-95045352022-09-24 Prevalence of Escherichia coli ST1193 Causing Intracranial Infection in Changsha, China Zhong, Yi-Ming Zhang, Xiao-He Ma, Zheng Liu, Wen-En Trop Med Infect Dis Article ST1193 is an emerging new virulent and resistant clone among Escherichia coli with a tendency to spread rapidly across the globe. However, the prevalence of intracranial infection-causing E. coli ST1193 is rarely reported. This study aimed at determining the prevalence of E. coli ST1193 isolates, causing intracranial infections in Changsha, central China. A total of 28 E. coli isolates were collected from the cerebrospinal fluid of patients with intracranial infection over a four-year period. All isolates were differentiated using multilocus sequence typing (MLST), and phylogenetic grouping, and tested for antibiotic resistance. MLST analysis showed 11 sequence types (ST) among the 28 E. coli isolates. The most prevalent ST was B2-ST1193 (28.6%, 8/28), followed by B2-ST131 (21.4%, 6/28) and F-ST648 (10.7%, 3/28). Of the eight ST1193 isolates, three carried CTX-M-55, and one carried CTX-M-27. All eight ST1193 isolates were resistant to Ciprofloxacin, showing gyrA1AB/parC4A mutations. Two ST1193 isolates carried the aac(6′)-Ib-cr gene. All ST1193 isolates were recovered from infants with meningitis, with a fatal outcome for one three-month-old infant. ST1193 has emerged as the predominant type of E. coli strain causing intracranial infections in Changsha, China. This study highlights the importance of implementing appropriate surveillance measures to prevent the spread of this emerging public health threat. MDPI 2022-08-31 /pmc/articles/PMC9504535/ /pubmed/36136628 http://dx.doi.org/10.3390/tropicalmed7090217 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhong, Yi-Ming
Zhang, Xiao-He
Ma, Zheng
Liu, Wen-En
Prevalence of Escherichia coli ST1193 Causing Intracranial Infection in Changsha, China
title Prevalence of Escherichia coli ST1193 Causing Intracranial Infection in Changsha, China
title_full Prevalence of Escherichia coli ST1193 Causing Intracranial Infection in Changsha, China
title_fullStr Prevalence of Escherichia coli ST1193 Causing Intracranial Infection in Changsha, China
title_full_unstemmed Prevalence of Escherichia coli ST1193 Causing Intracranial Infection in Changsha, China
title_short Prevalence of Escherichia coli ST1193 Causing Intracranial Infection in Changsha, China
title_sort prevalence of escherichia coli st1193 causing intracranial infection in changsha, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504535/
https://www.ncbi.nlm.nih.gov/pubmed/36136628
http://dx.doi.org/10.3390/tropicalmed7090217
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