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Racial/Ethnic Differences in the Pharmacokinetics of Antipsychotics: Focusing on East Asians

Empirical clinical studies have suggested that East Asian patients may require lower dosages of psychotropic drugs, such as antipsychotics, lithium, and antidepressants, than non-Asians. Both the pharmacokinetic and pharmacodynamic properties of a drug can affect the clinical response of an illness....

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Autor principal: Lin, Shih-Ku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504618/
https://www.ncbi.nlm.nih.gov/pubmed/36143147
http://dx.doi.org/10.3390/jpm12091362
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author Lin, Shih-Ku
author_facet Lin, Shih-Ku
author_sort Lin, Shih-Ku
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description Empirical clinical studies have suggested that East Asian patients may require lower dosages of psychotropic drugs, such as antipsychotics, lithium, and antidepressants, than non-Asians. Both the pharmacokinetic and pharmacodynamic properties of a drug can affect the clinical response of an illness. The levels of antipsychotics used for the treatment of schizophrenia may affect patient clinical responses; several factors can affect these levels, including patient medication adherence, body weight (BW) or body mass index, smoking habits, and sex. The cytochrome P450 (CYP) system is a major factor affecting the blood levels of antipsychotics because many antipsychotics are metabolized by this system. There were notable genetic differences between people of different races. In this study, we determined the racial or ethnic differences in the metabolic patterns of some selected antipsychotics by reviewing therapeutic drug monitoring studies in East Asian populations. The plasma concentrations of haloperidol, clozapine, quetiapine, aripiprazole, and lurasidone, which are metabolized by specific CYP enzymes, were determined to be higher, under the same daily dose, in East Asian populations than in Western populations.
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spelling pubmed-95046182022-09-24 Racial/Ethnic Differences in the Pharmacokinetics of Antipsychotics: Focusing on East Asians Lin, Shih-Ku J Pers Med Review Empirical clinical studies have suggested that East Asian patients may require lower dosages of psychotropic drugs, such as antipsychotics, lithium, and antidepressants, than non-Asians. Both the pharmacokinetic and pharmacodynamic properties of a drug can affect the clinical response of an illness. The levels of antipsychotics used for the treatment of schizophrenia may affect patient clinical responses; several factors can affect these levels, including patient medication adherence, body weight (BW) or body mass index, smoking habits, and sex. The cytochrome P450 (CYP) system is a major factor affecting the blood levels of antipsychotics because many antipsychotics are metabolized by this system. There were notable genetic differences between people of different races. In this study, we determined the racial or ethnic differences in the metabolic patterns of some selected antipsychotics by reviewing therapeutic drug monitoring studies in East Asian populations. The plasma concentrations of haloperidol, clozapine, quetiapine, aripiprazole, and lurasidone, which are metabolized by specific CYP enzymes, were determined to be higher, under the same daily dose, in East Asian populations than in Western populations. MDPI 2022-08-24 /pmc/articles/PMC9504618/ /pubmed/36143147 http://dx.doi.org/10.3390/jpm12091362 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin, Shih-Ku
Racial/Ethnic Differences in the Pharmacokinetics of Antipsychotics: Focusing on East Asians
title Racial/Ethnic Differences in the Pharmacokinetics of Antipsychotics: Focusing on East Asians
title_full Racial/Ethnic Differences in the Pharmacokinetics of Antipsychotics: Focusing on East Asians
title_fullStr Racial/Ethnic Differences in the Pharmacokinetics of Antipsychotics: Focusing on East Asians
title_full_unstemmed Racial/Ethnic Differences in the Pharmacokinetics of Antipsychotics: Focusing on East Asians
title_short Racial/Ethnic Differences in the Pharmacokinetics of Antipsychotics: Focusing on East Asians
title_sort racial/ethnic differences in the pharmacokinetics of antipsychotics: focusing on east asians
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504618/
https://www.ncbi.nlm.nih.gov/pubmed/36143147
http://dx.doi.org/10.3390/jpm12091362
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