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Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study

We investigated whether long-term consumption of two healthy diets (low-fat (LF) or Mediterranean (Med)) interacts with SIRT1 genotypes to modulate aging-related processes such as leucocyte telomere length (LTL), oxidative stress (OxS) and inflammation in patients with coronary heart disease (CHD)....

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Autores principales: Hidalgo-Moyano, Cristina, Rangel-Zuñiga, Oriol Alberto, Gomez-Delgado, Francisco, Alcala-Diaz, Juan F., Rodriguez-Cantalejo, Fernando, Yubero-Serrano, Elena M., Torres-Peña, Jose D., Arenas-de Larriva, Antonio P., Camargo, Antonio, Perez-Martinez, Pablo, Lopez-Miranda, Jose, Delgado-Lista, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504765/
https://www.ncbi.nlm.nih.gov/pubmed/36145164
http://dx.doi.org/10.3390/nu14183789
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author Hidalgo-Moyano, Cristina
Rangel-Zuñiga, Oriol Alberto
Gomez-Delgado, Francisco
Alcala-Diaz, Juan F.
Rodriguez-Cantalejo, Fernando
Yubero-Serrano, Elena M.
Torres-Peña, Jose D.
Arenas-de Larriva, Antonio P.
Camargo, Antonio
Perez-Martinez, Pablo
Lopez-Miranda, Jose
Delgado-Lista, Javier
author_facet Hidalgo-Moyano, Cristina
Rangel-Zuñiga, Oriol Alberto
Gomez-Delgado, Francisco
Alcala-Diaz, Juan F.
Rodriguez-Cantalejo, Fernando
Yubero-Serrano, Elena M.
Torres-Peña, Jose D.
Arenas-de Larriva, Antonio P.
Camargo, Antonio
Perez-Martinez, Pablo
Lopez-Miranda, Jose
Delgado-Lista, Javier
author_sort Hidalgo-Moyano, Cristina
collection PubMed
description We investigated whether long-term consumption of two healthy diets (low-fat (LF) or Mediterranean (Med)) interacts with SIRT1 genotypes to modulate aging-related processes such as leucocyte telomere length (LTL), oxidative stress (OxS) and inflammation in patients with coronary heart disease (CHD). LTL, inflammation, OxS markers (at baseline and after 4 years of follow-up) and SIRT1-Single Nucleotide Polymorphisms (SNPs) (rs7069102 and rs1885472) were determined in patients from the CORDIOPREV study. We analyzed the genotype-marker interactions and the effect of diet on these interactions. Regardless of the diet, we observed LTL maintenance in GG-carriers for the rs7069102, in contrast to carriers of the minor C allele, where it decreased after follow-up (p = 0.001). The GG-carriers showed an increase in reduced/oxidized glutathione (GSH/GSSG) ratio (p = 0.003), lower lipid peroxidation products (LPO) levels (p < 0.001) and a greater decrease in tumor necrosis factor-alpha (TNF-α) levels (p < 0.001) after follow-up. After the LF diet intervention, the GG-carriers showed stabilization in LTL which was significant compared to the C allele subjects (p = 0.037), although the protective effects found for inflammation and OxS markers remained significant after follow-up with the two diets. Patients who are homozygous for the SIRT1-SNP rs7069102 (the most common genotype) may benefit from healthy diets, as suggested by improvements in OxS and inflammation in patients with CHD, which may indicate the slowing-down of the aging process and its related diseases.
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spelling pubmed-95047652022-09-24 Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study Hidalgo-Moyano, Cristina Rangel-Zuñiga, Oriol Alberto Gomez-Delgado, Francisco Alcala-Diaz, Juan F. Rodriguez-Cantalejo, Fernando Yubero-Serrano, Elena M. Torres-Peña, Jose D. Arenas-de Larriva, Antonio P. Camargo, Antonio Perez-Martinez, Pablo Lopez-Miranda, Jose Delgado-Lista, Javier Nutrients Article We investigated whether long-term consumption of two healthy diets (low-fat (LF) or Mediterranean (Med)) interacts with SIRT1 genotypes to modulate aging-related processes such as leucocyte telomere length (LTL), oxidative stress (OxS) and inflammation in patients with coronary heart disease (CHD). LTL, inflammation, OxS markers (at baseline and after 4 years of follow-up) and SIRT1-Single Nucleotide Polymorphisms (SNPs) (rs7069102 and rs1885472) were determined in patients from the CORDIOPREV study. We analyzed the genotype-marker interactions and the effect of diet on these interactions. Regardless of the diet, we observed LTL maintenance in GG-carriers for the rs7069102, in contrast to carriers of the minor C allele, where it decreased after follow-up (p = 0.001). The GG-carriers showed an increase in reduced/oxidized glutathione (GSH/GSSG) ratio (p = 0.003), lower lipid peroxidation products (LPO) levels (p < 0.001) and a greater decrease in tumor necrosis factor-alpha (TNF-α) levels (p < 0.001) after follow-up. After the LF diet intervention, the GG-carriers showed stabilization in LTL which was significant compared to the C allele subjects (p = 0.037), although the protective effects found for inflammation and OxS markers remained significant after follow-up with the two diets. Patients who are homozygous for the SIRT1-SNP rs7069102 (the most common genotype) may benefit from healthy diets, as suggested by improvements in OxS and inflammation in patients with CHD, which may indicate the slowing-down of the aging process and its related diseases. MDPI 2022-09-14 /pmc/articles/PMC9504765/ /pubmed/36145164 http://dx.doi.org/10.3390/nu14183789 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hidalgo-Moyano, Cristina
Rangel-Zuñiga, Oriol Alberto
Gomez-Delgado, Francisco
Alcala-Diaz, Juan F.
Rodriguez-Cantalejo, Fernando
Yubero-Serrano, Elena M.
Torres-Peña, Jose D.
Arenas-de Larriva, Antonio P.
Camargo, Antonio
Perez-Martinez, Pablo
Lopez-Miranda, Jose
Delgado-Lista, Javier
Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study
title Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study
title_full Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study
title_fullStr Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study
title_full_unstemmed Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study
title_short Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study
title_sort diet and sirt1 genotype interact to modulate aging-related processes in patients with coronary heart disease: from the cordioprev study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504765/
https://www.ncbi.nlm.nih.gov/pubmed/36145164
http://dx.doi.org/10.3390/nu14183789
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