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Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies

This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO, mainly located in leukocytes and which in turn contribute to cellular oxidative stress. The reactions of RCS with various organic m...

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Autores principales: Andrés, Celia María Curieses, Pérez de la Lastra, José Manuel, Juan, Celia Andrés, Plou, Francisco J., Pérez-Lebeña, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504810/
https://www.ncbi.nlm.nih.gov/pubmed/36142645
http://dx.doi.org/10.3390/ijms231810735
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author Andrés, Celia María Curieses
Pérez de la Lastra, José Manuel
Juan, Celia Andrés
Plou, Francisco J.
Pérez-Lebeña, Eduardo
author_facet Andrés, Celia María Curieses
Pérez de la Lastra, José Manuel
Juan, Celia Andrés
Plou, Francisco J.
Pérez-Lebeña, Eduardo
author_sort Andrés, Celia María Curieses
collection PubMed
description This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO, mainly located in leukocytes and which in turn contribute to cellular oxidative stress. The reactions of RCS with various organic molecules such as amines, amino acids, proteins, lipids, carbohydrates, nucleic acids, and DNA are described, and an attempt is made to explain the chemical mechanisms of the formation of the various chlorinated derivatives and the data available so far on the effects of MPO, RCS and halogenative stress. Their presence in numerous pathologies such as atherosclerosis, arthritis, neurological and renal diseases, diabetes, and obesity is reviewed and were found to be a feature of debilitating diseases.
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spelling pubmed-95048102022-09-24 Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies Andrés, Celia María Curieses Pérez de la Lastra, José Manuel Juan, Celia Andrés Plou, Francisco J. Pérez-Lebeña, Eduardo Int J Mol Sci Review This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO, mainly located in leukocytes and which in turn contribute to cellular oxidative stress. The reactions of RCS with various organic molecules such as amines, amino acids, proteins, lipids, carbohydrates, nucleic acids, and DNA are described, and an attempt is made to explain the chemical mechanisms of the formation of the various chlorinated derivatives and the data available so far on the effects of MPO, RCS and halogenative stress. Their presence in numerous pathologies such as atherosclerosis, arthritis, neurological and renal diseases, diabetes, and obesity is reviewed and were found to be a feature of debilitating diseases. MDPI 2022-09-14 /pmc/articles/PMC9504810/ /pubmed/36142645 http://dx.doi.org/10.3390/ijms231810735 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Andrés, Celia María Curieses
Pérez de la Lastra, José Manuel
Juan, Celia Andrés
Plou, Francisco J.
Pérez-Lebeña, Eduardo
Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
title Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
title_full Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
title_fullStr Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
title_full_unstemmed Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
title_short Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
title_sort hypochlorous acid chemistry in mammalian cells—influence on infection and role in various pathologies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504810/
https://www.ncbi.nlm.nih.gov/pubmed/36142645
http://dx.doi.org/10.3390/ijms231810735
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