Transgenerationally Transmitted DNA Demethylation of a Spontaneous Epialleles Using CRISPR/dCas9-TET1cd Targeted Epigenetic Editing in Arabidopsis

CRISPR/dCas9 is an important DNA modification tool in which a disarmed Cas9 protein with no nuclease activity is fused with a specific DNA modifying enzyme. A previous study reported that overexpression of the TET1 catalytic domain (TET1cd) reduces genome-wide methylation in Arabidopsis. A spontaneo...

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Detalles Bibliográficos
Autores principales: Wang, Min, He, Li, Chen, Bowei, Wang, Yanwei, Wang, Lishan, Zhou, Wei, Zhang, Tianxu, Cao, Lesheng, Zhang, Peng, Xie, Linan, Zhang, Qingzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504898/
https://www.ncbi.nlm.nih.gov/pubmed/36142407
http://dx.doi.org/10.3390/ijms231810492

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