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Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?

Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple...

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Autores principales: Morán-Serradilla, Cristina, Angulo-Elizari, Eduardo, Henriquez-Figuereo, Andreina, Sanmartín, Carmen, Sharma, Arun K., Plano, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504997/
https://www.ncbi.nlm.nih.gov/pubmed/36144278
http://dx.doi.org/10.3390/metabo12090874
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author Morán-Serradilla, Cristina
Angulo-Elizari, Eduardo
Henriquez-Figuereo, Andreina
Sanmartín, Carmen
Sharma, Arun K.
Plano, Daniel
author_facet Morán-Serradilla, Cristina
Angulo-Elizari, Eduardo
Henriquez-Figuereo, Andreina
Sanmartín, Carmen
Sharma, Arun K.
Plano, Daniel
author_sort Morán-Serradilla, Cristina
collection PubMed
description Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple factors, such as its chemical form, dose, and its metabolism. The understanding of its complex biochemistry is necessary as it has been demonstrated that the metabolites of the Se molecules used to be the ones that exert the biological activity. Therefore, the aim of this review is to summarize the recent information about its most remarkable metabolites of acknowledged biological effects: hydrogen selenide (HSe(−)/H(2)Se) and methylselenol (CH(3)SeH). In addition, special attention is paid to the main seleno-containing precursors of these derivatives and their role in different pathologies.
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spelling pubmed-95049972022-09-24 Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses? Morán-Serradilla, Cristina Angulo-Elizari, Eduardo Henriquez-Figuereo, Andreina Sanmartín, Carmen Sharma, Arun K. Plano, Daniel Metabolites Review Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple factors, such as its chemical form, dose, and its metabolism. The understanding of its complex biochemistry is necessary as it has been demonstrated that the metabolites of the Se molecules used to be the ones that exert the biological activity. Therefore, the aim of this review is to summarize the recent information about its most remarkable metabolites of acknowledged biological effects: hydrogen selenide (HSe(−)/H(2)Se) and methylselenol (CH(3)SeH). In addition, special attention is paid to the main seleno-containing precursors of these derivatives and their role in different pathologies. MDPI 2022-09-16 /pmc/articles/PMC9504997/ /pubmed/36144278 http://dx.doi.org/10.3390/metabo12090874 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Morán-Serradilla, Cristina
Angulo-Elizari, Eduardo
Henriquez-Figuereo, Andreina
Sanmartín, Carmen
Sharma, Arun K.
Plano, Daniel
Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?
title Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?
title_full Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?
title_fullStr Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?
title_full_unstemmed Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?
title_short Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?
title_sort seleno-metabolites and their precursors: a new dawn for several illnesses?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504997/
https://www.ncbi.nlm.nih.gov/pubmed/36144278
http://dx.doi.org/10.3390/metabo12090874
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