Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling

Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk. Here we set out to examine the role of this pseudokinase in atherosclerotic plaque development. Human endarterectomy atherosclerotic tiss...

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Detalles Bibliográficos
Autores principales: Martinez-Campesino, Laura, Kocsy, Klaudia, Cañedo, Jaime, Johnston, Jessica M., Moss, Charlotte E., Johnston, Simon A., Hamby, Stephen, Goodall, Alison H., Redgrave, Jessica, Francis, Sheila E., Kiss-Toth, Endre, Wilson, Heather L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505024/
https://www.ncbi.nlm.nih.gov/pubmed/36158793
http://dx.doi.org/10.3389/fcvm.2022.948461

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