Cargando…

Antibodies against SARS-CoV-2 Alpha, Beta, and Gamma Variants in Pregnant Women and Their Neonates under Antenatal Vaccination with Moderna (mRNA-1273) Vaccine

The aim of the study was to examine the impact of COVID-19 vaccination on the anti-SARS-CoV-2 spike receptor binding domain IgG antibody (SRBD IgG) binding ratio (SBR) from Alpha, Beta, and Gamma variants of SARS-CoV-2 in pregnant women and neonates. The impact of antenatal influenza (flu) and pertu...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Wei-Chun, Lin, Yen-Pin, Cheng, Chao-Min, Shen, Ching-Fen, Ching, Alex, Chang, Ting-Chang, Shen, Ching-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505142/
https://www.ncbi.nlm.nih.gov/pubmed/36146492
http://dx.doi.org/10.3390/vaccines10091415
_version_ 1784796398720385024
author Chen, Wei-Chun
Lin, Yen-Pin
Cheng, Chao-Min
Shen, Ching-Fen
Ching, Alex
Chang, Ting-Chang
Shen, Ching-Ju
author_facet Chen, Wei-Chun
Lin, Yen-Pin
Cheng, Chao-Min
Shen, Ching-Fen
Ching, Alex
Chang, Ting-Chang
Shen, Ching-Ju
author_sort Chen, Wei-Chun
collection PubMed
description The aim of the study was to examine the impact of COVID-19 vaccination on the anti-SARS-CoV-2 spike receptor binding domain IgG antibody (SRBD IgG) binding ratio (SBR) from Alpha, Beta, and Gamma variants of SARS-CoV-2 in pregnant women and neonates. The impact of antenatal influenza (flu) and pertussis (Tdap) vaccines was also studied. We enrolled pregnant women vaccinated with the Moderna (mRNA-1273) vaccine during pregnancy and collected maternal plasma (MP) and neonatal cord blood (CB) during delivery to determine the SBR via enzyme-linked immunosorbent assays (ELISA). A total of 78 samples were collected from 39 pregnant women. The SBR was higher for Alpha variants compared to Beta/Gamma variants (MP: 63.95% vs. 47.91% vs. 43.48%, p = 0.0001; CB: 72.14% vs. 56.78% vs. 53.66%, p = 0.006). Pregnant women receiving two doses of the COVID-19 vaccine demonstrated a better SBR against SARS-CoV-2 Alpha, Beta, and Gamma variants than women receiving just a single dose. Women who received the Tdap/flu vaccines demonstrated a better SBR when two COVID-19 vaccine doses were < 6 weeks apart. A better SBR was detected among women who had more recently received their second COVID-19 vaccine dose. Two doses of the COVID-19 vaccine provided recipients with a better SBR for Alpha/Beta/Gamma variants. Although Tdap/flu vaccines may affect the efficacy of the COVID-19 vaccine, different vaccination timings can improve the SBR.
format Online
Article
Text
id pubmed-9505142
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95051422022-09-24 Antibodies against SARS-CoV-2 Alpha, Beta, and Gamma Variants in Pregnant Women and Their Neonates under Antenatal Vaccination with Moderna (mRNA-1273) Vaccine Chen, Wei-Chun Lin, Yen-Pin Cheng, Chao-Min Shen, Ching-Fen Ching, Alex Chang, Ting-Chang Shen, Ching-Ju Vaccines (Basel) Article The aim of the study was to examine the impact of COVID-19 vaccination on the anti-SARS-CoV-2 spike receptor binding domain IgG antibody (SRBD IgG) binding ratio (SBR) from Alpha, Beta, and Gamma variants of SARS-CoV-2 in pregnant women and neonates. The impact of antenatal influenza (flu) and pertussis (Tdap) vaccines was also studied. We enrolled pregnant women vaccinated with the Moderna (mRNA-1273) vaccine during pregnancy and collected maternal plasma (MP) and neonatal cord blood (CB) during delivery to determine the SBR via enzyme-linked immunosorbent assays (ELISA). A total of 78 samples were collected from 39 pregnant women. The SBR was higher for Alpha variants compared to Beta/Gamma variants (MP: 63.95% vs. 47.91% vs. 43.48%, p = 0.0001; CB: 72.14% vs. 56.78% vs. 53.66%, p = 0.006). Pregnant women receiving two doses of the COVID-19 vaccine demonstrated a better SBR against SARS-CoV-2 Alpha, Beta, and Gamma variants than women receiving just a single dose. Women who received the Tdap/flu vaccines demonstrated a better SBR when two COVID-19 vaccine doses were < 6 weeks apart. A better SBR was detected among women who had more recently received their second COVID-19 vaccine dose. Two doses of the COVID-19 vaccine provided recipients with a better SBR for Alpha/Beta/Gamma variants. Although Tdap/flu vaccines may affect the efficacy of the COVID-19 vaccine, different vaccination timings can improve the SBR. MDPI 2022-08-28 /pmc/articles/PMC9505142/ /pubmed/36146492 http://dx.doi.org/10.3390/vaccines10091415 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Wei-Chun
Lin, Yen-Pin
Cheng, Chao-Min
Shen, Ching-Fen
Ching, Alex
Chang, Ting-Chang
Shen, Ching-Ju
Antibodies against SARS-CoV-2 Alpha, Beta, and Gamma Variants in Pregnant Women and Their Neonates under Antenatal Vaccination with Moderna (mRNA-1273) Vaccine
title Antibodies against SARS-CoV-2 Alpha, Beta, and Gamma Variants in Pregnant Women and Their Neonates under Antenatal Vaccination with Moderna (mRNA-1273) Vaccine
title_full Antibodies against SARS-CoV-2 Alpha, Beta, and Gamma Variants in Pregnant Women and Their Neonates under Antenatal Vaccination with Moderna (mRNA-1273) Vaccine
title_fullStr Antibodies against SARS-CoV-2 Alpha, Beta, and Gamma Variants in Pregnant Women and Their Neonates under Antenatal Vaccination with Moderna (mRNA-1273) Vaccine
title_full_unstemmed Antibodies against SARS-CoV-2 Alpha, Beta, and Gamma Variants in Pregnant Women and Their Neonates under Antenatal Vaccination with Moderna (mRNA-1273) Vaccine
title_short Antibodies against SARS-CoV-2 Alpha, Beta, and Gamma Variants in Pregnant Women and Their Neonates under Antenatal Vaccination with Moderna (mRNA-1273) Vaccine
title_sort antibodies against sars-cov-2 alpha, beta, and gamma variants in pregnant women and their neonates under antenatal vaccination with moderna (mrna-1273) vaccine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505142/
https://www.ncbi.nlm.nih.gov/pubmed/36146492
http://dx.doi.org/10.3390/vaccines10091415
work_keys_str_mv AT chenweichun antibodiesagainstsarscov2alphabetaandgammavariantsinpregnantwomenandtheirneonatesunderantenatalvaccinationwithmodernamrna1273vaccine
AT linyenpin antibodiesagainstsarscov2alphabetaandgammavariantsinpregnantwomenandtheirneonatesunderantenatalvaccinationwithmodernamrna1273vaccine
AT chengchaomin antibodiesagainstsarscov2alphabetaandgammavariantsinpregnantwomenandtheirneonatesunderantenatalvaccinationwithmodernamrna1273vaccine
AT shenchingfen antibodiesagainstsarscov2alphabetaandgammavariantsinpregnantwomenandtheirneonatesunderantenatalvaccinationwithmodernamrna1273vaccine
AT chingalex antibodiesagainstsarscov2alphabetaandgammavariantsinpregnantwomenandtheirneonatesunderantenatalvaccinationwithmodernamrna1273vaccine
AT changtingchang antibodiesagainstsarscov2alphabetaandgammavariantsinpregnantwomenandtheirneonatesunderantenatalvaccinationwithmodernamrna1273vaccine
AT shenchingju antibodiesagainstsarscov2alphabetaandgammavariantsinpregnantwomenandtheirneonatesunderantenatalvaccinationwithmodernamrna1273vaccine