Cargando…

Characterization of Novel Bacteriophage vB_KpnP_ZX1 and Its Depolymerases with Therapeutic Potential for K57 Klebsiella pneumoniae Infection

A novel temperate phage vB_KpnP_ZX1 was isolated from hospital sewage samples using the clinically derived K57-type Klebsiella pneumoniae as a host. Phage vB_KpnP_ZX1, encoding three lysogen genes, the repressor, anti-repressor, and integrase, is the fourth phage of the genus Uetakevirus, family Pod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Ping, Ma, Wenjie, Shen, Jiayin, Zhou, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505181/ https://www.ncbi.nlm.nih.gov/pubmed/36145665 http://dx.doi.org/10.3390/pharmaceutics14091916

Ejemplares similares

Characterization and Therapeutic Potential of Bacteriophage-Encoded Polysaccharide Depolymerases with β Galactosidase Activity against Klebsiella pneumoniae K57 Capsular Type
por: V. Volozhantsev, Nikolay, et al.
Publicado: (2020)

Novel Klebsiella pneumoniae K23-Specific Bacteriophages From Different Families: Similarity of Depolymerases and Their Therapeutic Potential
por: Gorodnichev, Roman B., et al.
Publicado: (2021)

Bacteriophages with depolymerase activity in the control of antibiotic resistant Klebsiella pneumoniae biofilms
por: Zurabov, Fedor, et al.
Publicado: (2023)

Mechanistic Insights into the Capsule-Targeting Depolymerase from a Klebsiella pneumoniae Bacteriophage
por: Dunstan, Rhys A., et al.
Publicado: (2021)

Characterisation of Bacteriophage-Encoded Depolymerases Selective for Key Klebsiella pneumoniae Capsular Exopolysaccharides
por: Blundell-Hunter, George, et al.
Publicado: (2021)

Complete Nucleotide Sequence of Klebsiella pneumoniae Bacteriophage vB_KpnM_KpV477
por: Komisarova, Ekaterina V., et al.
Publicado: (2017)

Identification of three capsule depolymerases in a bacteriophage infecting Klebsiella pneumoniae capsular types K7, K20, and K27 and therapeutic application
por: Wu, Jia-Wen, et al.
Publicado: (2023)

Complete Genome Sequences of Lytic Polysaccharide-Degrading Klebsiella pneumoniae Bacteriophages vB_KpnS_FZ10, vB_KpnP_FZ12, vB_KpnM_FZ14, and vB_KpnS_FZ41
por: Zurabov, Fedor, et al.
Publicado: (2019)

Identification of a Depolymerase Specific for K64-Serotype Klebsiella pneumoniae: Potential Applications in Capsular Typing and Treatment
por: Li, Jiayin, et al.
Publicado: (2021)

Characterization and Genomic Analysis of Bacteriophage vB_KpnM_IME346 Targeting Clinical Klebsiella pneumoniae Strain of the K63 Capsular Type
por: Gao, Mingming, et al.
Publicado: (2022)

Characterization of vB_Kpn_F48, a Newly Discovered Lytic Bacteriophage for Klebsiella pneumoniae of Sequence Type 101
por: Ciacci, Nagaia, et al.
Publicado: (2018)

Isolation of a Bacteriophage Specific for a New Capsular Type of Klebsiella pneumoniae and Characterization of Its Polysaccharide Depolymerase
por: Hsu, Chun-Ru, et al.
Publicado: (2013)

Characterization and Functional Studies of a Novel Depolymerase Against K19-Type Klebsiella pneumoniae
por: Hua, Yunfen, et al.
Publicado: (2022)

Isolation, Genomic Analysis, and Preliminary Application of a Bovine Klebsiella pneumoniae Bacteriophage vB_Kpn_B01
por: Luo, Zidan, et al.
Publicado: (2021)

Characterization of a Lytic Bacteriophage and Demonstration of Its Combined Lytic Effect with a K2 Depolymerase on the Hypervirulent Klebsiella pneumoniae Strain 52145
por: Pertics, Botond Zsombor, et al.
Publicado: (2023)

Distribution of mcr-1 Harboring Hypervirulent Klebsiella pneumoniae in Clinical Specimens and Lytic Activity of Bacteriophage KpnM Against Isolates
por: Aslam, Bilal, et al.
Publicado: (2022)

Isolation and Characterization of Two Klebsiella pneumoniae Phages Encoding Divergent Depolymerases
por: Domingo-Calap, Pilar, et al.
Publicado: (2020)

Isolation and Characterization of a Novel Lytic Bacteriophage against the K2 Capsule-Expressing Hypervirulent Klebsiella pneumoniae Strain 52145, and Identification of Its Functional Depolymerase
por: Pertics, Botond Zsombor, et al.
Publicado: (2021)

Morphological, biological, and genomic characterization of Klebsiella pneumoniae phage vB_Kpn_ZC2
por: Fayez, Mohamed S., et al.
Publicado: (2023)

Characteristics of a Bacteriophage, vB_Kox_ZX8, Isolated From Clinical Klebsiella oxytoca and Its Therapeutic Effect on Mice Bacteremia
por: Li, Ping, et al.
Publicado: (2021)

Phenotypic and Genomic Comparison of Klebsiella pneumoniae Lytic Phages: vB_KpnM-VAC66 and vB_KpnM-VAC13
por: Pacios, Olga, et al.
Publicado: (2021)

Correction: Morphological, biological, and genomic characterization of Klebsiella pneumoniae phage vB_Kpn_ZC2
por: Fayez, Mohamed S., et al.
Publicado: (2023)

Complete Genome Sequence of Klebsiella pneumoniae Bacteriophage KpS110, Encoding Five Tail-Associated Proteins with Putative Polysaccharide Depolymerase Domains
por: Volozhantsev, Nikolay V., et al.
Publicado: (2023)

Bacteriophage-Derived Depolymerases against Bacterial Biofilm
por: Topka-Bielecka, Gracja, et al.
Publicado: (2021)

Klebsiella phage KP34gp57 capsular depolymerase structure and function: from a serendipitous finding to the design of active mini-enzymes against K. pneumoniae
por: Maciejewska, Barbara, et al.
Publicado: (2023)

A Response to Article “Distribution of Mcr-1 Harboring Hypervirulent Klebsiella Pneumoniae in Clinical Specimens and Lytic Activity of Bacteriophage KpnM Against Isolates” [Letter]
por: Panjaitan, Novaria Sari Dewi, et al.
Publicado: (2022)

Depolymerase improves gentamicin efficacy during Klebsiella pneumoniae induced murine infection
por: Bansal, Shruti, et al.
Publicado: (2014)

Aeromonas punctata derived depolymerase improves susceptibility of Klebsiella pneumoniae biofilm to gentamicin
por: Bansal, Shruti, et al.
Publicado: (2015)

Phage-Borne Depolymerases Decrease Klebsiella pneumoniae Resistance to Innate Defense Mechanisms
por: Majkowska-Skrobek, Grazyna, et al.
Publicado: (2018)

Identification of Two Depolymerases From Phage IME205 and Their Antivirulent Functions on K47 Capsule of Klebsiella pneumoniae
por: Liu, Yannan, et al.
Publicado: (2020)

Exploring the enzymatic activity of depolymerase gp531 from Klebsiella pneumoniae jumbo phage RaK2
por: Noreika, Algirdas, et al.
Publicado: (2023)

Characterization and comprehensive genome analysis of novel bacteriophage, vB_Kpn_ZCKp20p, with lytic and anti-biofilm potential against clinical multidrug-resistant Klebsiella pneumoniae
por: Zaki, Bishoy Maher, et al.
Publicado: (2023)

Why Hypothetical Protein KPN00728 of Klebsiella pneumoniae Should Be Classified as Chain C of Succinate Dehydrogenase?
por: Choi, Sy Bing, et al.
Publicado: (2009)

The Negative Effects of KPN00353 on Glycerol Kinase and Microaerobic 1,3-Propanediol Production in Klebsiella pneumoniae
por: Jeng, Wen-Yih, et al.
Publicado: (2017)

A Response to Article “Distribution of Mcr-1 Harboring Hypervirulent Klebsiella pneumoniae in Clinical Specimens and Lytic Activity of Bacteriophage KpnM Against Isolates” [Response to Letter]
por: Aslam, Bilal, et al.
Publicado: (2022)

Development of Klebsiella pneumoniae Capsule Polysaccharide-Conjugated Vaccine Candidates Using Phage Depolymerases
por: Lin, Tzu-Lung, et al.
Publicado: (2022)

Characteristics of Environmental Klebsiella pneumoniae and Klebsiella oxytoca Bacteriophages and Their Therapeutic Applications
por: Weber-Dąbrowska, Beata, et al.
Publicado: (2023)

Combination Therapy of Phage vB_KpnM_P-KP2 and Gentamicin Combats Acute Pneumonia Caused by K47 Serotype Klebsiella pneumoniae
por: Wang, Zijing, et al.
Publicado: (2021)

Isolation of Klebsiella pneumoniae Phage vB_KpnS_MK54 and Pathological Assessment of Endolysin in the Treatment of Pneumonia Mice Model
por: Lu, Biao, et al.
Publicado: (2022)

Identification of a phage-derived depolymerase specific for KL47 capsule of Klebsiella pneumoniae and its therapeutic potential in mice
por: Li, Min, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hnuu5lvf4oqftg5117ntf5a8ub