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Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative

Pharmacogenetics (PGx) has the potential to improve opioid medication management. Here, we present patient perception data, pharmacogenetic data and medication management trends in patients with chronic pain (arm 1) and opioid use disorder (arm 2) treated at Cooper University Health Care in Camden C...

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Autores principales: Kusic, Dara, Heil, Jessica, Zajic, Stefan, Brangan, Andrew, Dairo, Oluseun, Smith, Gretchen, Morales-Scheihing, Diego, Buono, Russell J., Ferraro, Thomas N., Haroz, Rachel, Salzman, Matthew, Baston, Kaitlan, Bodofsky, Elliot, Sabia, Michael, Resch, Alissa, Scheinfeldt, Laura B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505214/
https://www.ncbi.nlm.nih.gov/pubmed/36145611
http://dx.doi.org/10.3390/pharmaceutics14091863
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author Kusic, Dara
Heil, Jessica
Zajic, Stefan
Brangan, Andrew
Dairo, Oluseun
Smith, Gretchen
Morales-Scheihing, Diego
Buono, Russell J.
Ferraro, Thomas N.
Haroz, Rachel
Salzman, Matthew
Baston, Kaitlan
Bodofsky, Elliot
Sabia, Michael
Resch, Alissa
Scheinfeldt, Laura B.
author_facet Kusic, Dara
Heil, Jessica
Zajic, Stefan
Brangan, Andrew
Dairo, Oluseun
Smith, Gretchen
Morales-Scheihing, Diego
Buono, Russell J.
Ferraro, Thomas N.
Haroz, Rachel
Salzman, Matthew
Baston, Kaitlan
Bodofsky, Elliot
Sabia, Michael
Resch, Alissa
Scheinfeldt, Laura B.
author_sort Kusic, Dara
collection PubMed
description Pharmacogenetics (PGx) has the potential to improve opioid medication management. Here, we present patient perception data, pharmacogenetic data and medication management trends in patients with chronic pain (arm 1) and opioid use disorder (arm 2) treated at Cooper University Health Care in Camden City, NJ. Our results demonstrate that the majority of patients in both arms of the study (55% and 65%, respectively) are open to pharmacogenetic testing, and most (66% and 69%, respectively) believe that genetic testing has the potential to improve their medical care. Our results further support the potential for CYP2D6 PGx testing to inform chronic pain medication management for poor metabolizers (PMs) and ultrarapid metabolizers (UMs). Future efforts to implement PGx testing in chronic pain management, however, must address patient concerns about genetic test result access and genetic discrimination.
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spelling pubmed-95052142022-09-24 Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative Kusic, Dara Heil, Jessica Zajic, Stefan Brangan, Andrew Dairo, Oluseun Smith, Gretchen Morales-Scheihing, Diego Buono, Russell J. Ferraro, Thomas N. Haroz, Rachel Salzman, Matthew Baston, Kaitlan Bodofsky, Elliot Sabia, Michael Resch, Alissa Scheinfeldt, Laura B. Pharmaceutics Article Pharmacogenetics (PGx) has the potential to improve opioid medication management. Here, we present patient perception data, pharmacogenetic data and medication management trends in patients with chronic pain (arm 1) and opioid use disorder (arm 2) treated at Cooper University Health Care in Camden City, NJ. Our results demonstrate that the majority of patients in both arms of the study (55% and 65%, respectively) are open to pharmacogenetic testing, and most (66% and 69%, respectively) believe that genetic testing has the potential to improve their medical care. Our results further support the potential for CYP2D6 PGx testing to inform chronic pain medication management for poor metabolizers (PMs) and ultrarapid metabolizers (UMs). Future efforts to implement PGx testing in chronic pain management, however, must address patient concerns about genetic test result access and genetic discrimination. MDPI 2022-09-03 /pmc/articles/PMC9505214/ /pubmed/36145611 http://dx.doi.org/10.3390/pharmaceutics14091863 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kusic, Dara
Heil, Jessica
Zajic, Stefan
Brangan, Andrew
Dairo, Oluseun
Smith, Gretchen
Morales-Scheihing, Diego
Buono, Russell J.
Ferraro, Thomas N.
Haroz, Rachel
Salzman, Matthew
Baston, Kaitlan
Bodofsky, Elliot
Sabia, Michael
Resch, Alissa
Scheinfeldt, Laura B.
Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative
title Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative
title_full Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative
title_fullStr Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative
title_full_unstemmed Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative
title_short Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative
title_sort patient perceptions and potential utility of pharmacogenetic testing in chronic pain management and opioid use disorder in the camden opioid research initiative
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505214/
https://www.ncbi.nlm.nih.gov/pubmed/36145611
http://dx.doi.org/10.3390/pharmaceutics14091863
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