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Involvement of Inflammation and Its Resolution in Disease and Therapeutics

Inflammation plays a critical role in the response to and survival from injuries and/or infections. It occurs in two phases: initiation and resolution; however, when these events do not resolve and persist over time, the inflammatory response becomes chronic, prompting diseases that affect several s...

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Autores principales: Alfaro, Sebastián, Acuña, Vania, Ceriani, Ricardo, Cavieres, María Fernanda, Weinstein-Oppenheimer, Caroline Ruth, Campos-Estrada, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505300/
https://www.ncbi.nlm.nih.gov/pubmed/36142625
http://dx.doi.org/10.3390/ijms231810719
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author Alfaro, Sebastián
Acuña, Vania
Ceriani, Ricardo
Cavieres, María Fernanda
Weinstein-Oppenheimer, Caroline Ruth
Campos-Estrada, Carolina
author_facet Alfaro, Sebastián
Acuña, Vania
Ceriani, Ricardo
Cavieres, María Fernanda
Weinstein-Oppenheimer, Caroline Ruth
Campos-Estrada, Carolina
author_sort Alfaro, Sebastián
collection PubMed
description Inflammation plays a critical role in the response to and survival from injuries and/or infections. It occurs in two phases: initiation and resolution; however, when these events do not resolve and persist over time, the inflammatory response becomes chronic, prompting diseases that affect several systems and organs, such as the vasculature and the skin. Here, we reviewed inflammation that occurs in selected infectious and sterile pathologies. Thus, the immune processes induced by bacterial sepsis as well as T. cruzi and SARS-CoV-2 infections are shown. In addition, vaccine adjuvants as well as atherosclerosis are revised as examples of sterile-mediated inflammation. An example of the consequences of a lack of inflammation resolution is given through the revision of wound healing and chronic wounds. Then, we revised the resolution of the latter through advanced therapies represented by cell therapy and tissue engineering approaches, showing how they contribute to control chronic inflammation and therefore wound healing. Finally, new pharmacological insights into the management of chronic inflammation addressing the resolution of inflammation based on pro-resolving mediators, such as lipoxin, maresin, and resolvins, examining their biosynthesis, biological properties, and pharmacokinetic and pharmaceuticals limitations, are given. We conclude that resolution pharmacology and advanced therapies are promising tools to restore the inflammation homeostasis.
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spelling pubmed-95053002022-09-24 Involvement of Inflammation and Its Resolution in Disease and Therapeutics Alfaro, Sebastián Acuña, Vania Ceriani, Ricardo Cavieres, María Fernanda Weinstein-Oppenheimer, Caroline Ruth Campos-Estrada, Carolina Int J Mol Sci Review Inflammation plays a critical role in the response to and survival from injuries and/or infections. It occurs in two phases: initiation and resolution; however, when these events do not resolve and persist over time, the inflammatory response becomes chronic, prompting diseases that affect several systems and organs, such as the vasculature and the skin. Here, we reviewed inflammation that occurs in selected infectious and sterile pathologies. Thus, the immune processes induced by bacterial sepsis as well as T. cruzi and SARS-CoV-2 infections are shown. In addition, vaccine adjuvants as well as atherosclerosis are revised as examples of sterile-mediated inflammation. An example of the consequences of a lack of inflammation resolution is given through the revision of wound healing and chronic wounds. Then, we revised the resolution of the latter through advanced therapies represented by cell therapy and tissue engineering approaches, showing how they contribute to control chronic inflammation and therefore wound healing. Finally, new pharmacological insights into the management of chronic inflammation addressing the resolution of inflammation based on pro-resolving mediators, such as lipoxin, maresin, and resolvins, examining their biosynthesis, biological properties, and pharmacokinetic and pharmaceuticals limitations, are given. We conclude that resolution pharmacology and advanced therapies are promising tools to restore the inflammation homeostasis. MDPI 2022-09-14 /pmc/articles/PMC9505300/ /pubmed/36142625 http://dx.doi.org/10.3390/ijms231810719 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alfaro, Sebastián
Acuña, Vania
Ceriani, Ricardo
Cavieres, María Fernanda
Weinstein-Oppenheimer, Caroline Ruth
Campos-Estrada, Carolina
Involvement of Inflammation and Its Resolution in Disease and Therapeutics
title Involvement of Inflammation and Its Resolution in Disease and Therapeutics
title_full Involvement of Inflammation and Its Resolution in Disease and Therapeutics
title_fullStr Involvement of Inflammation and Its Resolution in Disease and Therapeutics
title_full_unstemmed Involvement of Inflammation and Its Resolution in Disease and Therapeutics
title_short Involvement of Inflammation and Its Resolution in Disease and Therapeutics
title_sort involvement of inflammation and its resolution in disease and therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505300/
https://www.ncbi.nlm.nih.gov/pubmed/36142625
http://dx.doi.org/10.3390/ijms231810719
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