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The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
Non-O blood groups are associated with decreased insulin sensitivity and risk of type 2 diabetes. A recent study pinpointed the associations between ABO blood groups and gut microbiome, which may serve as potential mediators for the observed increased disease risks. We aimed to characterize associat...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505353/ https://www.ncbi.nlm.nih.gov/pubmed/36144194 http://dx.doi.org/10.3390/metabo12090787 |
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author | Li-Gao, Ruifang Grubbs, Kirk Bertoni, Alain G. Hoffman, Kristi L. Petrosino, Joseph F. Ramesh, Gautam Wu, Martin Rotter, Jerome I. Chen, Yii-Der Ida Evans, Anne M. Robinson, Richard J. Sommerville, Laura Mook-Kanamori, Dennis Goodarzi, Mark O. Michelotti, Gregory A. Sheridan, Patricia A. |
author_facet | Li-Gao, Ruifang Grubbs, Kirk Bertoni, Alain G. Hoffman, Kristi L. Petrosino, Joseph F. Ramesh, Gautam Wu, Martin Rotter, Jerome I. Chen, Yii-Der Ida Evans, Anne M. Robinson, Richard J. Sommerville, Laura Mook-Kanamori, Dennis Goodarzi, Mark O. Michelotti, Gregory A. Sheridan, Patricia A. |
author_sort | Li-Gao, Ruifang |
collection | PubMed |
description | Non-O blood groups are associated with decreased insulin sensitivity and risk of type 2 diabetes. A recent study pinpointed the associations between ABO blood groups and gut microbiome, which may serve as potential mediators for the observed increased disease risks. We aimed to characterize associations between ABO haplotypes and insulin-related traits as well as potential mediating pathways. We assessed insulin homeostasis in African Americans (AAs; n = 109) and non-Hispanic whites (n = 210) from the Microbiome and Insulin Longitudinal Evaluation Study. The ABO haplotype was determined by six SNPs located in the ABO gene. Based on prior knowledge, we included 21 gut bacteria and 13 plasma metabolites for mediation analysis. In the white study cohort (60 ± 9 years, 42% male), compared to the O1 haplotype, A1 was associated with a higher Matsuda insulin sensitivity index, while a lower relative abundance of Bacteroides massiliensis and lactate levels. Lactate was a likely mediator of this association but not Bacteroides massiliensis. In the AAs group (57 ± 8 years, 33% male), we found no association between any haplotype and insulin-related traits. In conclusion, the A1 haplotype may promote healthy insulin sensitivity in non-Hispanic whites and lactate likely play a role in this process but not selected gut bacteria. |
format | Online Article Text |
id | pubmed-9505353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95053532022-09-24 The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) Li-Gao, Ruifang Grubbs, Kirk Bertoni, Alain G. Hoffman, Kristi L. Petrosino, Joseph F. Ramesh, Gautam Wu, Martin Rotter, Jerome I. Chen, Yii-Der Ida Evans, Anne M. Robinson, Richard J. Sommerville, Laura Mook-Kanamori, Dennis Goodarzi, Mark O. Michelotti, Gregory A. Sheridan, Patricia A. Metabolites Article Non-O blood groups are associated with decreased insulin sensitivity and risk of type 2 diabetes. A recent study pinpointed the associations between ABO blood groups and gut microbiome, which may serve as potential mediators for the observed increased disease risks. We aimed to characterize associations between ABO haplotypes and insulin-related traits as well as potential mediating pathways. We assessed insulin homeostasis in African Americans (AAs; n = 109) and non-Hispanic whites (n = 210) from the Microbiome and Insulin Longitudinal Evaluation Study. The ABO haplotype was determined by six SNPs located in the ABO gene. Based on prior knowledge, we included 21 gut bacteria and 13 plasma metabolites for mediation analysis. In the white study cohort (60 ± 9 years, 42% male), compared to the O1 haplotype, A1 was associated with a higher Matsuda insulin sensitivity index, while a lower relative abundance of Bacteroides massiliensis and lactate levels. Lactate was a likely mediator of this association but not Bacteroides massiliensis. In the AAs group (57 ± 8 years, 33% male), we found no association between any haplotype and insulin-related traits. In conclusion, the A1 haplotype may promote healthy insulin sensitivity in non-Hispanic whites and lactate likely play a role in this process but not selected gut bacteria. MDPI 2022-08-25 /pmc/articles/PMC9505353/ /pubmed/36144194 http://dx.doi.org/10.3390/metabo12090787 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li-Gao, Ruifang Grubbs, Kirk Bertoni, Alain G. Hoffman, Kristi L. Petrosino, Joseph F. Ramesh, Gautam Wu, Martin Rotter, Jerome I. Chen, Yii-Der Ida Evans, Anne M. Robinson, Richard J. Sommerville, Laura Mook-Kanamori, Dennis Goodarzi, Mark O. Michelotti, Gregory A. Sheridan, Patricia A. The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
title | The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
title_full | The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
title_fullStr | The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
title_full_unstemmed | The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
title_short | The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
title_sort | roles of gut microbiome and plasma metabolites in the associations between abo blood groups and insulin homeostasis: the microbiome and insulin longitudinal evaluation study (miles) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505353/ https://www.ncbi.nlm.nih.gov/pubmed/36144194 http://dx.doi.org/10.3390/metabo12090787 |
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