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Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation

Chronic constipation (CC) is a highly prevalent and burdensome gastrointestinal disorder. Accumulating evidence highlights the link between imbalances in the gut microbiome and constipation. However, the mechanisms by which the microbiome and microbial metabolites affect gut movement remain poorly u...

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Autores principales: Pan, Ruili, Wang, Linlin, Xu, Xiaopeng, Chen, Ying, Wang, Haojue, Wang, Gang, Zhao, Jianxin, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505360/
https://www.ncbi.nlm.nih.gov/pubmed/36145079
http://dx.doi.org/10.3390/nu14183704
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author Pan, Ruili
Wang, Linlin
Xu, Xiaopeng
Chen, Ying
Wang, Haojue
Wang, Gang
Zhao, Jianxin
Chen, Wei
author_facet Pan, Ruili
Wang, Linlin
Xu, Xiaopeng
Chen, Ying
Wang, Haojue
Wang, Gang
Zhao, Jianxin
Chen, Wei
author_sort Pan, Ruili
collection PubMed
description Chronic constipation (CC) is a highly prevalent and burdensome gastrointestinal disorder. Accumulating evidence highlights the link between imbalances in the gut microbiome and constipation. However, the mechanisms by which the microbiome and microbial metabolites affect gut movement remain poorly understood. In this review, we discuss recent studies on the alteration in the gut microbiota in patients with CC and the effectiveness of probiotics in treating gut motility disorder. We highlight the mechanisms that explain how the gut microbiome and its metabolism are linked to gut movement and how intestinal microecological interventions may counteract these changes based on the enteric nervous system, the central nervous system, the immune function, and the ability to modify intestinal secretion and the hormonal milieu. In particular, microbiota-based approaches that modulate the levels of short-chain fatty acids and tryptophan catabolites or that target the 5-hydroxytryptamine and Toll-like receptor pathways may hold therapeutic promise. Finally, we discuss the existing limitations of microecological management in treating constipation and suggest feasible directions for future research.
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spelling pubmed-95053602022-09-24 Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation Pan, Ruili Wang, Linlin Xu, Xiaopeng Chen, Ying Wang, Haojue Wang, Gang Zhao, Jianxin Chen, Wei Nutrients Review Chronic constipation (CC) is a highly prevalent and burdensome gastrointestinal disorder. Accumulating evidence highlights the link between imbalances in the gut microbiome and constipation. However, the mechanisms by which the microbiome and microbial metabolites affect gut movement remain poorly understood. In this review, we discuss recent studies on the alteration in the gut microbiota in patients with CC and the effectiveness of probiotics in treating gut motility disorder. We highlight the mechanisms that explain how the gut microbiome and its metabolism are linked to gut movement and how intestinal microecological interventions may counteract these changes based on the enteric nervous system, the central nervous system, the immune function, and the ability to modify intestinal secretion and the hormonal milieu. In particular, microbiota-based approaches that modulate the levels of short-chain fatty acids and tryptophan catabolites or that target the 5-hydroxytryptamine and Toll-like receptor pathways may hold therapeutic promise. Finally, we discuss the existing limitations of microecological management in treating constipation and suggest feasible directions for future research. MDPI 2022-09-08 /pmc/articles/PMC9505360/ /pubmed/36145079 http://dx.doi.org/10.3390/nu14183704 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pan, Ruili
Wang, Linlin
Xu, Xiaopeng
Chen, Ying
Wang, Haojue
Wang, Gang
Zhao, Jianxin
Chen, Wei
Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation
title Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation
title_full Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation
title_fullStr Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation
title_full_unstemmed Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation
title_short Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation
title_sort crosstalk between the gut microbiome and colonic motility in chronic constipation: potential mechanisms and microbiota modulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505360/
https://www.ncbi.nlm.nih.gov/pubmed/36145079
http://dx.doi.org/10.3390/nu14183704
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