New 11-Methoxymethylgermacranolides from the Whole Plant of Carpesium divaricatum

Eight new 11-methoxymethylgermacranolides (1–8) were isolated from the ethanol extract of the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 was establish...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Zhang, Haixin, Lin, Chunyu, Fu, Lu, Zou, Zhongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505371/
https://www.ncbi.nlm.nih.gov/pubmed/36144722
http://dx.doi.org/10.3390/molecules27185991
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author Zhang, Tao
Zhang, Haixin
Lin, Chunyu
Fu, Lu
Zou, Zhongmei
author_facet Zhang, Tao
Zhang, Haixin
Lin, Chunyu
Fu, Lu
Zou, Zhongmei
author_sort Zhang, Tao
collection PubMed
description Eight new 11-methoxymethylgermacranolides (1–8) were isolated from the ethanol extract of the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 was established by electronic circular dichroism (ECD) spectrum and X-ray crystallographic analysis, and the stereochemistry of the new compounds 2–8 were determined by similar ECD data with 1. The absolute configurations of 5 and 7 were further confirmed by using quantum chemical electronic circular dichroism (ECD) calculations. Compound 4 exhibited weak cytotoxicity against MCF-7 cells. Compound 8 could potently decrease PGE2 productions in LPS-induced RAW 264.7 cells.
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spelling pubmed-95053712022-09-24 New 11-Methoxymethylgermacranolides from the Whole Plant of Carpesium divaricatum Zhang, Tao Zhang, Haixin Lin, Chunyu Fu, Lu Zou, Zhongmei Molecules Article Eight new 11-methoxymethylgermacranolides (1–8) were isolated from the ethanol extract of the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 was established by electronic circular dichroism (ECD) spectrum and X-ray crystallographic analysis, and the stereochemistry of the new compounds 2–8 were determined by similar ECD data with 1. The absolute configurations of 5 and 7 were further confirmed by using quantum chemical electronic circular dichroism (ECD) calculations. Compound 4 exhibited weak cytotoxicity against MCF-7 cells. Compound 8 could potently decrease PGE2 productions in LPS-induced RAW 264.7 cells. MDPI 2022-09-14 /pmc/articles/PMC9505371/ /pubmed/36144722 http://dx.doi.org/10.3390/molecules27185991 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Tao
Zhang, Haixin
Lin, Chunyu
Fu, Lu
Zou, Zhongmei
New 11-Methoxymethylgermacranolides from the Whole Plant of Carpesium divaricatum
title New 11-Methoxymethylgermacranolides from the Whole Plant of Carpesium divaricatum
title_full New 11-Methoxymethylgermacranolides from the Whole Plant of Carpesium divaricatum
title_fullStr New 11-Methoxymethylgermacranolides from the Whole Plant of Carpesium divaricatum
title_full_unstemmed New 11-Methoxymethylgermacranolides from the Whole Plant of Carpesium divaricatum
title_short New 11-Methoxymethylgermacranolides from the Whole Plant of Carpesium divaricatum
title_sort new 11-methoxymethylgermacranolides from the whole plant of carpesium divaricatum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505371/
https://www.ncbi.nlm.nih.gov/pubmed/36144722
http://dx.doi.org/10.3390/molecules27185991
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