An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native Pigs

Pigs are promising donors of biological materials for xenotransplantation; however, cell surface carbohydrate antigens, including galactose-alpha-1,3-galactose (α-Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd blood group antigens, play a significant role in porcine xenograft rejection. Inactivati...

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Detalles Bibliográficos
Autores principales: Yoon, Seungwon, Lee, Seulgi, Park, Chungyu, Choi, Hyunyong, Yoo, Minwoo, Lee, Sang Chul, Hyun, Cheol-Ho, Kim, Nameun, Kang, Taeyoung, Son, Eugene, Ghosh, Mrinmoy, Son, Young-Ok, Hur, Chang-Gi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505423/
https://www.ncbi.nlm.nih.gov/pubmed/36146581
http://dx.doi.org/10.3390/vaccines10091503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505423/
https://www.ncbi.nlm.nih.gov/pubmed/36146581
http://dx.doi.org/10.3390/vaccines10091503

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