Photolyase Production and Current Applications: A Review

The photolyase family consists of flavoproteins with enzyme activity able to repair ultraviolet light radiation damage by photoreactivation. DNA damage by the formation of a cyclobutane pyrimidine dimer (CPD) and a pyrimidine-pyrimidone (6-4) photoproduct can lead to multiple affections such as cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Ramírez-Gamboa, Diana, Díaz-Zamorano, Ana Laura, Meléndez-Sánchez, Edgar Ricardo, Reyes-Pardo, Humberto, Villaseñor-Zepeda, Karen Rocio, López-Arellanes, Miguel E., Sosa-Hernández, Juan Eduardo, Coronado-Apodaca, Karina G., Gámez-Méndez, Ana, Afewerki, Samson, Iqbal, Hafiz M. N., Parra-Saldivar, Roberto, Martínez-Ruiz, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505440/
https://www.ncbi.nlm.nih.gov/pubmed/36144740
http://dx.doi.org/10.3390/molecules27185998
Descripción
Sumario:The photolyase family consists of flavoproteins with enzyme activity able to repair ultraviolet light radiation damage by photoreactivation. DNA damage by the formation of a cyclobutane pyrimidine dimer (CPD) and a pyrimidine-pyrimidone (6-4) photoproduct can lead to multiple affections such as cellular apoptosis and mutagenesis that can evolve into skin cancer. The development of integrated applications to prevent the negative effects of prolonged sunlight exposure, usually during outdoor activities, is imperative. This study presents the functions, characteristics, and types of photolyases, their therapeutic and cosmetic applications, and additionally explores some photolyase-producing microorganisms and drug delivery systems.

Ejemplares similares