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Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects
Abnormality in myocardial copper homeostasis is believed to contribute to the development of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients with Wilson’s disease, demonstrates beneficial effects in patients with hypertrophic cardiomyopathy. This review aims to...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505553/ https://www.ncbi.nlm.nih.gov/pubmed/36145368 http://dx.doi.org/10.3390/ph15091145 |
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author | Ramli, Fitri Fareez Hashim, Syed Alhafiz Syed Raman, Betty Mahmod, Masliza Kamisah, Yusof |
author_facet | Ramli, Fitri Fareez Hashim, Syed Alhafiz Syed Raman, Betty Mahmod, Masliza Kamisah, Yusof |
author_sort | Ramli, Fitri Fareez |
collection | PubMed |
description | Abnormality in myocardial copper homeostasis is believed to contribute to the development of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients with Wilson’s disease, demonstrates beneficial effects in patients with hypertrophic cardiomyopathy. This review aims to present the updated development of the roles of trientine in hypertrophic cardiomyopathy. The drug has been demonstrated in animal studies to restore myocardial intracellular copper content. However, its mechanisms for improving the medical condition remain unclear. Thus, comprehending its mechanistic aspects in cardiomyopathy is crucial and could help to expedite future research. |
format | Online Article Text |
id | pubmed-9505553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95055532022-09-24 Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects Ramli, Fitri Fareez Hashim, Syed Alhafiz Syed Raman, Betty Mahmod, Masliza Kamisah, Yusof Pharmaceuticals (Basel) Review Abnormality in myocardial copper homeostasis is believed to contribute to the development of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients with Wilson’s disease, demonstrates beneficial effects in patients with hypertrophic cardiomyopathy. This review aims to present the updated development of the roles of trientine in hypertrophic cardiomyopathy. The drug has been demonstrated in animal studies to restore myocardial intracellular copper content. However, its mechanisms for improving the medical condition remain unclear. Thus, comprehending its mechanistic aspects in cardiomyopathy is crucial and could help to expedite future research. MDPI 2022-09-14 /pmc/articles/PMC9505553/ /pubmed/36145368 http://dx.doi.org/10.3390/ph15091145 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ramli, Fitri Fareez Hashim, Syed Alhafiz Syed Raman, Betty Mahmod, Masliza Kamisah, Yusof Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects |
title | Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects |
title_full | Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects |
title_fullStr | Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects |
title_full_unstemmed | Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects |
title_short | Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects |
title_sort | role of trientine in hypertrophic cardiomyopathy: a review of mechanistic aspects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505553/ https://www.ncbi.nlm.nih.gov/pubmed/36145368 http://dx.doi.org/10.3390/ph15091145 |
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