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Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects

Abnormality in myocardial copper homeostasis is believed to contribute to the development of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients with Wilson’s disease, demonstrates beneficial effects in patients with hypertrophic cardiomyopathy. This review aims to...

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Autores principales: Ramli, Fitri Fareez, Hashim, Syed Alhafiz Syed, Raman, Betty, Mahmod, Masliza, Kamisah, Yusof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505553/
https://www.ncbi.nlm.nih.gov/pubmed/36145368
http://dx.doi.org/10.3390/ph15091145
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author Ramli, Fitri Fareez
Hashim, Syed Alhafiz Syed
Raman, Betty
Mahmod, Masliza
Kamisah, Yusof
author_facet Ramli, Fitri Fareez
Hashim, Syed Alhafiz Syed
Raman, Betty
Mahmod, Masliza
Kamisah, Yusof
author_sort Ramli, Fitri Fareez
collection PubMed
description Abnormality in myocardial copper homeostasis is believed to contribute to the development of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients with Wilson’s disease, demonstrates beneficial effects in patients with hypertrophic cardiomyopathy. This review aims to present the updated development of the roles of trientine in hypertrophic cardiomyopathy. The drug has been demonstrated in animal studies to restore myocardial intracellular copper content. However, its mechanisms for improving the medical condition remain unclear. Thus, comprehending its mechanistic aspects in cardiomyopathy is crucial and could help to expedite future research.
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spelling pubmed-95055532022-09-24 Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects Ramli, Fitri Fareez Hashim, Syed Alhafiz Syed Raman, Betty Mahmod, Masliza Kamisah, Yusof Pharmaceuticals (Basel) Review Abnormality in myocardial copper homeostasis is believed to contribute to the development of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients with Wilson’s disease, demonstrates beneficial effects in patients with hypertrophic cardiomyopathy. This review aims to present the updated development of the roles of trientine in hypertrophic cardiomyopathy. The drug has been demonstrated in animal studies to restore myocardial intracellular copper content. However, its mechanisms for improving the medical condition remain unclear. Thus, comprehending its mechanistic aspects in cardiomyopathy is crucial and could help to expedite future research. MDPI 2022-09-14 /pmc/articles/PMC9505553/ /pubmed/36145368 http://dx.doi.org/10.3390/ph15091145 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ramli, Fitri Fareez
Hashim, Syed Alhafiz Syed
Raman, Betty
Mahmod, Masliza
Kamisah, Yusof
Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects
title Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects
title_full Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects
title_fullStr Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects
title_full_unstemmed Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects
title_short Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects
title_sort role of trientine in hypertrophic cardiomyopathy: a review of mechanistic aspects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505553/
https://www.ncbi.nlm.nih.gov/pubmed/36145368
http://dx.doi.org/10.3390/ph15091145
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