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Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids

Depressive disorders are among the most disabling diseases experienced around the world, and their incidence has significantly increased over the last few decades due to multiple environmental, social, and biological factors. The search for new pharmacological alternatives to treat depression is a g...

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Autores principales: German-Ponciano, León Jesús, Rosas-Sánchez, Gilberto Uriel, Cueto-Escobedo, Jonathan, Fernández-Demeneghi, Rafael, Guillén-Ruiz, Gabriel, Soria-Fregozo, César, Herrera-Huerta, Emma Virginia, Rodríguez-Landa, Juan Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505567/
https://www.ncbi.nlm.nih.gov/pubmed/36142808
http://dx.doi.org/10.3390/ijms231810896
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author German-Ponciano, León Jesús
Rosas-Sánchez, Gilberto Uriel
Cueto-Escobedo, Jonathan
Fernández-Demeneghi, Rafael
Guillén-Ruiz, Gabriel
Soria-Fregozo, César
Herrera-Huerta, Emma Virginia
Rodríguez-Landa, Juan Francisco
author_facet German-Ponciano, León Jesús
Rosas-Sánchez, Gilberto Uriel
Cueto-Escobedo, Jonathan
Fernández-Demeneghi, Rafael
Guillén-Ruiz, Gabriel
Soria-Fregozo, César
Herrera-Huerta, Emma Virginia
Rodríguez-Landa, Juan Francisco
author_sort German-Ponciano, León Jesús
collection PubMed
description Depressive disorders are among the most disabling diseases experienced around the world, and their incidence has significantly increased over the last few decades due to multiple environmental, social, and biological factors. The search for new pharmacological alternatives to treat depression is a global priority. In preclinical research, molecules obtained from plants, such as flavonoids, have shown promising antidepressant-like properties through several mechanisms of action that have not been fully elucidated, including crossing of the blood brain barrier (BBB). This review will focus on discussing the main findings related to the participation of the serotonergic system and brain-derived neurotrophic factor (BDNF) on the antidepressant-like effect of some flavonoids reported by behavioral, neurochemical, and molecular studies. In this sense, evidence shows that depressive individuals have low levels of serotonin and BDNF, while flavonoids can reverse it. Finally, the elucidation of the mechanism used by flavonoids to modulate serotonin and BDNF will contribute to our understanding of the neurobiological bases underlying the antidepressant-like effects produced by these natural compounds.
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spelling pubmed-95055672022-09-24 Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids German-Ponciano, León Jesús Rosas-Sánchez, Gilberto Uriel Cueto-Escobedo, Jonathan Fernández-Demeneghi, Rafael Guillén-Ruiz, Gabriel Soria-Fregozo, César Herrera-Huerta, Emma Virginia Rodríguez-Landa, Juan Francisco Int J Mol Sci Review Depressive disorders are among the most disabling diseases experienced around the world, and their incidence has significantly increased over the last few decades due to multiple environmental, social, and biological factors. The search for new pharmacological alternatives to treat depression is a global priority. In preclinical research, molecules obtained from plants, such as flavonoids, have shown promising antidepressant-like properties through several mechanisms of action that have not been fully elucidated, including crossing of the blood brain barrier (BBB). This review will focus on discussing the main findings related to the participation of the serotonergic system and brain-derived neurotrophic factor (BDNF) on the antidepressant-like effect of some flavonoids reported by behavioral, neurochemical, and molecular studies. In this sense, evidence shows that depressive individuals have low levels of serotonin and BDNF, while flavonoids can reverse it. Finally, the elucidation of the mechanism used by flavonoids to modulate serotonin and BDNF will contribute to our understanding of the neurobiological bases underlying the antidepressant-like effects produced by these natural compounds. MDPI 2022-09-17 /pmc/articles/PMC9505567/ /pubmed/36142808 http://dx.doi.org/10.3390/ijms231810896 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
German-Ponciano, León Jesús
Rosas-Sánchez, Gilberto Uriel
Cueto-Escobedo, Jonathan
Fernández-Demeneghi, Rafael
Guillén-Ruiz, Gabriel
Soria-Fregozo, César
Herrera-Huerta, Emma Virginia
Rodríguez-Landa, Juan Francisco
Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids
title Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids
title_full Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids
title_fullStr Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids
title_full_unstemmed Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids
title_short Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids
title_sort participation of the serotonergic system and brain-derived neurotrophic factor in the antidepressant-like effect of flavonoids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505567/
https://www.ncbi.nlm.nih.gov/pubmed/36142808
http://dx.doi.org/10.3390/ijms231810896
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