Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity

To discover novel herbicidal compounds with favorable activity, a range of phenylpyridine-moiety-containing α-trifluorothioanisole derivatives were designed, synthesized, and identified via NMR and HRMS. Preliminary screening of greenhouse-based herbicidal activity revealed that compound 5a exhibite...

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Autores principales: Cai, Zengfei, Zhang, Wenliang, Yan, Zhongjie, Du, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505602/
https://www.ncbi.nlm.nih.gov/pubmed/36144624
http://dx.doi.org/10.3390/molecules27185879
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author Cai, Zengfei
Zhang, Wenliang
Yan, Zhongjie
Du, Xiaohua
author_facet Cai, Zengfei
Zhang, Wenliang
Yan, Zhongjie
Du, Xiaohua
author_sort Cai, Zengfei
collection PubMed
description To discover novel herbicidal compounds with favorable activity, a range of phenylpyridine-moiety-containing α-trifluorothioanisole derivatives were designed, synthesized, and identified via NMR and HRMS. Preliminary screening of greenhouse-based herbicidal activity revealed that compound 5a exhibited >85% inhibitory activity against broadleaf weeds Amaranthus retroflexus, Abutilon theophrasti, and Eclipta prostrate at 37.5 g a.i./hm(2), which was slightly superior to that of fomesafen. The current study suggests that compound 5a could be further optimized as an herbicide candidate to control various broadleaf weeds.
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spelling pubmed-95056022022-09-24 Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity Cai, Zengfei Zhang, Wenliang Yan, Zhongjie Du, Xiaohua Molecules Article To discover novel herbicidal compounds with favorable activity, a range of phenylpyridine-moiety-containing α-trifluorothioanisole derivatives were designed, synthesized, and identified via NMR and HRMS. Preliminary screening of greenhouse-based herbicidal activity revealed that compound 5a exhibited >85% inhibitory activity against broadleaf weeds Amaranthus retroflexus, Abutilon theophrasti, and Eclipta prostrate at 37.5 g a.i./hm(2), which was slightly superior to that of fomesafen. The current study suggests that compound 5a could be further optimized as an herbicide candidate to control various broadleaf weeds. MDPI 2022-09-10 /pmc/articles/PMC9505602/ /pubmed/36144624 http://dx.doi.org/10.3390/molecules27185879 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cai, Zengfei
Zhang, Wenliang
Yan, Zhongjie
Du, Xiaohua
Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
title Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
title_full Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
title_fullStr Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
title_full_unstemmed Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
title_short Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
title_sort synthesis of novel α-trifluorothioanisole derivatives containing phenylpyridine moieties with herbicidal activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505602/
https://www.ncbi.nlm.nih.gov/pubmed/36144624
http://dx.doi.org/10.3390/molecules27185879
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AT yanzhongjie synthesisofnovelatrifluorothioanisolederivativescontainingphenylpyridinemoietieswithherbicidalactivity
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