Cargando…
Anti-HBc IgG Responses Occurring at the Early Phase of Infection Correlate Negatively with HBV Replication in a Mouse Model
Anti-HBc IgG is usually recognized as a diagnostic marker of hepatitis B, while the functional role anti-HBc IgG in HBV infection has not been fully elucidated. In this study, we firstly investigated the relationship between the anti-HBc IgG responses and the replication of HBV using AAV8-1.3HBV inf...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505635/ https://www.ncbi.nlm.nih.gov/pubmed/36146817 http://dx.doi.org/10.3390/v14092011 |
_version_ | 1784796522023485440 |
---|---|
author | Wang, Xuyang Zhang, Yumeng Ben, Yinyin Qiu, Chao Wu, Jing Zhang, Wenhong Wan, Yanmin |
author_facet | Wang, Xuyang Zhang, Yumeng Ben, Yinyin Qiu, Chao Wu, Jing Zhang, Wenhong Wan, Yanmin |
author_sort | Wang, Xuyang |
collection | PubMed |
description | Anti-HBc IgG is usually recognized as a diagnostic marker of hepatitis B, while the functional role anti-HBc IgG in HBV infection has not been fully elucidated. In this study, we firstly investigated the relationship between the anti-HBc IgG responses and the replication of HBV using AAV8-1.3HBV infected C57BL/6N mice. Our data showed that the anti-HBc IgG responses at the early phase of infection correlated negatively with the concentrations of circulating HBsAg and HBV DNA at both the early and chronic phases of infection. This observation was confirmed by an independent experiment using AAV8-1.3HBV infected C57BL/6J mice. Furthermore, to comprehend the potential causal relationship between the anti-HBc IgG responses and HBV infection, mice were treated with an anti-HBc monoclonal antibody at three days post AAV8-1.3HBV infection. Our data showed that the anti-HBc mAb significantly suppressed the fold increase of circulating HBsAg level, and the protective effect was not affected by NK cell depletion. Collectively, our study demonstrated that anti-HBc antibodies occurring at the early phase of HBV infection may contribute to the constraint of the virus replication, which might be developed as an immunotherapy for hepatitis B. |
format | Online Article Text |
id | pubmed-9505635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95056352022-09-24 Anti-HBc IgG Responses Occurring at the Early Phase of Infection Correlate Negatively with HBV Replication in a Mouse Model Wang, Xuyang Zhang, Yumeng Ben, Yinyin Qiu, Chao Wu, Jing Zhang, Wenhong Wan, Yanmin Viruses Article Anti-HBc IgG is usually recognized as a diagnostic marker of hepatitis B, while the functional role anti-HBc IgG in HBV infection has not been fully elucidated. In this study, we firstly investigated the relationship between the anti-HBc IgG responses and the replication of HBV using AAV8-1.3HBV infected C57BL/6N mice. Our data showed that the anti-HBc IgG responses at the early phase of infection correlated negatively with the concentrations of circulating HBsAg and HBV DNA at both the early and chronic phases of infection. This observation was confirmed by an independent experiment using AAV8-1.3HBV infected C57BL/6J mice. Furthermore, to comprehend the potential causal relationship between the anti-HBc IgG responses and HBV infection, mice were treated with an anti-HBc monoclonal antibody at three days post AAV8-1.3HBV infection. Our data showed that the anti-HBc mAb significantly suppressed the fold increase of circulating HBsAg level, and the protective effect was not affected by NK cell depletion. Collectively, our study demonstrated that anti-HBc antibodies occurring at the early phase of HBV infection may contribute to the constraint of the virus replication, which might be developed as an immunotherapy for hepatitis B. MDPI 2022-09-11 /pmc/articles/PMC9505635/ /pubmed/36146817 http://dx.doi.org/10.3390/v14092011 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Xuyang Zhang, Yumeng Ben, Yinyin Qiu, Chao Wu, Jing Zhang, Wenhong Wan, Yanmin Anti-HBc IgG Responses Occurring at the Early Phase of Infection Correlate Negatively with HBV Replication in a Mouse Model |
title | Anti-HBc IgG Responses Occurring at the Early Phase of Infection Correlate Negatively with HBV Replication in a Mouse Model |
title_full | Anti-HBc IgG Responses Occurring at the Early Phase of Infection Correlate Negatively with HBV Replication in a Mouse Model |
title_fullStr | Anti-HBc IgG Responses Occurring at the Early Phase of Infection Correlate Negatively with HBV Replication in a Mouse Model |
title_full_unstemmed | Anti-HBc IgG Responses Occurring at the Early Phase of Infection Correlate Negatively with HBV Replication in a Mouse Model |
title_short | Anti-HBc IgG Responses Occurring at the Early Phase of Infection Correlate Negatively with HBV Replication in a Mouse Model |
title_sort | anti-hbc igg responses occurring at the early phase of infection correlate negatively with hbv replication in a mouse model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505635/ https://www.ncbi.nlm.nih.gov/pubmed/36146817 http://dx.doi.org/10.3390/v14092011 |
work_keys_str_mv | AT wangxuyang antihbciggresponsesoccurringattheearlyphaseofinfectioncorrelatenegativelywithhbvreplicationinamousemodel AT zhangyumeng antihbciggresponsesoccurringattheearlyphaseofinfectioncorrelatenegativelywithhbvreplicationinamousemodel AT benyinyin antihbciggresponsesoccurringattheearlyphaseofinfectioncorrelatenegativelywithhbvreplicationinamousemodel AT qiuchao antihbciggresponsesoccurringattheearlyphaseofinfectioncorrelatenegativelywithhbvreplicationinamousemodel AT wujing antihbciggresponsesoccurringattheearlyphaseofinfectioncorrelatenegativelywithhbvreplicationinamousemodel AT zhangwenhong antihbciggresponsesoccurringattheearlyphaseofinfectioncorrelatenegativelywithhbvreplicationinamousemodel AT wanyanmin antihbciggresponsesoccurringattheearlyphaseofinfectioncorrelatenegativelywithhbvreplicationinamousemodel |