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Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study

Limited data concerning the development of autoimmune skin diseases after COVID-19 vaccination are currently available. Recently, a few reports described the development, worsening or recurrence of alopecia areata after the administration of COVID-19 vaccines. High variability in terms of disease on...

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Autores principales: Tassone, Francesco, Cappilli, Simone, Antonelli, Flaminia, Zingarelli, Ruggiero, Chiricozzi, Andrea, Peris, Ketty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505739/
https://www.ncbi.nlm.nih.gov/pubmed/36146545
http://dx.doi.org/10.3390/vaccines10091467
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author Tassone, Francesco
Cappilli, Simone
Antonelli, Flaminia
Zingarelli, Ruggiero
Chiricozzi, Andrea
Peris, Ketty
author_facet Tassone, Francesco
Cappilli, Simone
Antonelli, Flaminia
Zingarelli, Ruggiero
Chiricozzi, Andrea
Peris, Ketty
author_sort Tassone, Francesco
collection PubMed
description Limited data concerning the development of autoimmune skin diseases after COVID-19 vaccination are currently available. Recently, a few reports described the development, worsening or recurrence of alopecia areata after the administration of COVID-19 vaccines. High variability in terms of disease onset following vaccination as well as the heterogeneous topical and/or systemic treatment approaches have been described. Methods: All patient-related data and images were obtained as part of clinical routine. Diagnosis of alopecia areata was established according to clinical and trichoscopic findings, along with the exclusion of common differential diagnoses. Results. Twenty-four patients, 20 females (83.3%) and four males (16.7%), with a mean age of 39.1 years (age range: 14–66 years), were examined for the occurrence of alopecia areata within 16 weeks after COVID-19 vaccination. Out of 24, 14 patients (58.3%) experienced a patchy alopecia areata, while an extensive disease occurred in 10/24 patients (41.7%): six patients with whole scalp involvement (alopecia areata totalis) and four patients with the whole body affected (alopecia areata universalis). Twelve patients reported a history of autoimmune disease (50%). Treatment with topical corticosteroid was performed in almost all patients with patchy alopecia areata, whilst it was associated with systemic drugs (corticosteroids, minoxidil, cyclosporin) in the case of generalized alopecia areata and alopecia areata universalis. Mean baseline values of Severity of Alopecia Tool (SALT) score decreased from 43.4 to 36.6 after 12 weeks of treatment, with evidence of hair regrowth in 16/21 patients. Conclusion. This study described the occurrence of alopecia areata after COVID-19 vaccination and its management that implicates the use of both topical and systemic therapies.
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spelling pubmed-95057392022-09-24 Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study Tassone, Francesco Cappilli, Simone Antonelli, Flaminia Zingarelli, Ruggiero Chiricozzi, Andrea Peris, Ketty Vaccines (Basel) Case Report Limited data concerning the development of autoimmune skin diseases after COVID-19 vaccination are currently available. Recently, a few reports described the development, worsening or recurrence of alopecia areata after the administration of COVID-19 vaccines. High variability in terms of disease onset following vaccination as well as the heterogeneous topical and/or systemic treatment approaches have been described. Methods: All patient-related data and images were obtained as part of clinical routine. Diagnosis of alopecia areata was established according to clinical and trichoscopic findings, along with the exclusion of common differential diagnoses. Results. Twenty-four patients, 20 females (83.3%) and four males (16.7%), with a mean age of 39.1 years (age range: 14–66 years), were examined for the occurrence of alopecia areata within 16 weeks after COVID-19 vaccination. Out of 24, 14 patients (58.3%) experienced a patchy alopecia areata, while an extensive disease occurred in 10/24 patients (41.7%): six patients with whole scalp involvement (alopecia areata totalis) and four patients with the whole body affected (alopecia areata universalis). Twelve patients reported a history of autoimmune disease (50%). Treatment with topical corticosteroid was performed in almost all patients with patchy alopecia areata, whilst it was associated with systemic drugs (corticosteroids, minoxidil, cyclosporin) in the case of generalized alopecia areata and alopecia areata universalis. Mean baseline values of Severity of Alopecia Tool (SALT) score decreased from 43.4 to 36.6 after 12 weeks of treatment, with evidence of hair regrowth in 16/21 patients. Conclusion. This study described the occurrence of alopecia areata after COVID-19 vaccination and its management that implicates the use of both topical and systemic therapies. MDPI 2022-09-05 /pmc/articles/PMC9505739/ /pubmed/36146545 http://dx.doi.org/10.3390/vaccines10091467 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Tassone, Francesco
Cappilli, Simone
Antonelli, Flaminia
Zingarelli, Ruggiero
Chiricozzi, Andrea
Peris, Ketty
Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study
title Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study
title_full Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study
title_fullStr Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study
title_full_unstemmed Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study
title_short Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study
title_sort alopecia areata occurring after covid-19 vaccination: a single-center, cross-sectional study
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505739/
https://www.ncbi.nlm.nih.gov/pubmed/36146545
http://dx.doi.org/10.3390/vaccines10091467
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