Role of the Guanidinium Groups in Ligand–Receptor Binding of Arginine-Containing Short Peptides to the Slow Sodium Channel: Quantitative Approach to Drug Design of Peptide Analgesics

Several arginine-containing short peptides have been shown by the patch-clamp method to effectively modulate the Na(V)1.8 channel activation gating system, which makes them promising candidates for the role of a novel analgesic medicinal substance. As demonstrated by the organotypic tissue culture m...

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Detalles Bibliográficos
Autores principales: Plakhova, Vera B., Samosvat, Dmitriy M., Zegrya, Georgy G., Penniyaynen, Valentina A., Kalinina, Arina D., Ke, Ma, Podzorova, Svetlana A., Krylov, Boris V., Rogachevskii, Ilya V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505852/
https://www.ncbi.nlm.nih.gov/pubmed/36142549
http://dx.doi.org/10.3390/ijms231810640

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