Cargando…

Identification of NHLRC1 as a Novel AKT Activator from a Lung Cancer Epigenome-Wide Association Study (EWAS)

Changes in DNA methylation identified by epigenome-wide association studies (EWAS) have been recently linked to increased lung cancer risk. However, the cellular effects of these differentially methylated positions (DMPs) are often unclear. Therefore, we investigated top differentially methylated po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Faltus, Christian, Lahnsteiner, Angelika, Barrdahl, Myrto, Assenov, Yassen, Hüsing, Anika, Bogatyrova, Olga, Laplana, Marina, Johnson, Theron, Muley, Thomas, Meister, Michael, Warth, Arne, Thomas, Michael, Plass, Christoph, Kaaks, Rudolf, Risch, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505874/ https://www.ncbi.nlm.nih.gov/pubmed/36142605 http://dx.doi.org/10.3390/ijms231810699

Ejemplares similares

Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers
por: Laplana, Marina, et al.
Publicado: (2021)

Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells
por: Schamschula, Esther, et al.
Publicado: (2021)

Epigenome-Wide Association Studies (EWAS) in Cancer
por: Verma, Mukesh
Publicado: (2012)

The EWAS Catalog: a database of epigenome-wide association studies
por: Battram, Thomas, et al.
Publicado: (2022)

pwrEWAS: a user-friendly tool for comprehensive power estimation for epigenome wide association studies (EWAS)
por: Graw, Stefan, et al.
Publicado: (2019)

Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study
por: Braun, Kim V. E., et al.
Publicado: (2017)

EWAS: epigenome-wide association study software 2.0
por: Xu, Jing, et al.
Publicado: (2018)

EWAS Atlas: a curated knowledgebase of epigenome-wide association studies
por: Li, Mengwei, et al.
Publicado: (2019)

The EpiDiverse Plant Epigenome-Wide Association Studies (EWAS) Pipeline
por: Can, Sultan Nilay, et al.
Publicado: (2021)

EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study
por: Xiong, Zhuang, et al.
Publicado: (2021)

Enrichment analysis with EpiAnnotator
por: Pageaud, Yoann, et al.
Publicado: (2018)

An interview with Ewa Czochrowska
por: Czochrowska, Ewa
Publicado: (2018)

Ten Years of EWAS
por: Wei, Siyu, et al.
Publicado: (2021)

Nhlrc2 is crucial during mouse gastrulation
por: Hiltunen, Anniina E., et al.
Publicado: (2022)

NHLRC2 expression is increased in idiopathic pulmonary fibrosis
por: Kreus, Mervi, et al.
Publicado: (2022)

Epigenome-wide association study (EWAS) for potential transgenerational disease epigenetic biomarkers in sperm following ancestral exposure to the pesticide methoxychlor
por: Nilsson, Eric E, et al.
Publicado: (2020)

Epigenome-Wide Association Study (EWAS) of Blood Lipids in Healthy Population from STANISLAS Family Study (SFS)
por: Xie, Ting, et al.
Publicado: (2019)

Circulating liver enzymes and risks of chronic diseases and mortality in the prospective EPIC-Heidelberg case-cohort study
por: Katzke, Verena, et al.
Publicado: (2020)

EWAS: epigenome-wide association studies software 1.0 – identifying the association between combinations of methylation levels and diseases
por: Xu, Jing, et al.
Publicado: (2016)

Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification
por: Melnik, Svitlana, et al.
Publicado: (2018)

Risk prediction models versus simplified selection criteria to determine eligibility for lung cancer screening: an analysis of German federal-wide survey and incidence data
por: Hüsing, Anika, et al.
Publicado: (2020)

Choice of surrogate tissue influences neonatal EWAS findings
por: Lin, Xinyi, et al.
Publicado: (2017)

A recurrent homozygous NHLRC1 variant in siblings with Lafora disease
por: Araya, Nami, et al.
Publicado: (2018)

High NHLRC2 expression is associated with shortened survival in lung adenocarcinoma
por: Kreus, Mervi A., et al.
Publicado: (2023)

Diversity in EWAS: current state, challenges, and solutions
por: Breeze, Charles E., et al.
Publicado: (2022)

Maftools: efficient and comprehensive analysis of somatic variants in cancer
por: Mayakonda, Anand, et al.
Publicado: (2018)

Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals
por: Chen, Yuqing, et al.
Publicado: (2021)

DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures
por: Gomez-Alonso, Monica del C., et al.
Publicado: (2021)

Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolism
por: Couarch, Philippe, et al.
Publicado: (2011)

Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease
por: Biterova, Ekaterina, et al.
Publicado: (2018)

Novel patients with NHLRC2 variants expand the phenotypic spectrum of FINCA disease
por: Tallgren, Antti, et al.
Publicado: (2023)

Ewa Orłowska on relational methods in logic and computer science
por: Golińska-Pilarek, Joanna, et al.
Publicado: (2018)

Lifestyle risk factors and residual life expectancy at age 40: a German cohort study
por: Li, Kuanrong, et al.
Publicado: (2014)

A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits
por: Battram, Thomas, et al.
Publicado: (2022)

An Environment-Wide Association Study (EWAS) on Type 2 Diabetes Mellitus
por: Patel, Chirag J., et al.
Publicado: (2010)

Novel mutation in the NHLRC1 gene in a Malian family with a severe phenotype of Lafora disease
por: Traoré, M., et al.
Publicado: (2009)

Broadening the phenotypic and molecular spectrum of FINCA syndrome: Biallelic NHLRC2 variants in 15 novel individuals
por: Sczakiel, Henrike L., et al.
Publicado: (2023)

Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML
por: Islam, Mirazul, et al.
Publicado: (2017)

Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation
por: Islam, Sumaiya A., et al.
Publicado: (2019)

Epigenetic screen identifies genotype- specific promoter DNA methylation and oncogenic potential of CHRNB4
por: Scherf, David B, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_lmo0kndu8evvdnr9veh917h51p