Cargando…

Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania

Measles is a highly infectious and sometimes deadly illness that is preventable with vaccination. The present research aims to analyze the most recent measles epidemic from Romania that occurred in a population with a falling desire to receive immunizations, by detailing the clinical picture and bio...

Descripción completa

Detalles Bibliográficos
Autores principales: Turaiche, Mirela, Feciche, Bogdan, Gluhovschi, Adrian, Bratosin, Felix, Bogdan, Iulia, Bota, Adrian Vasile, Grigoras, Mirela Loredana, Gurban, Camelia Vidita, Cerbu, Bianca, Toma, Ana-Olivia, Gurumurthy, Srivathsava, Wulandari, Prima Hapsari, Marincu, Iosif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505879/
https://www.ncbi.nlm.nih.gov/pubmed/36145449
http://dx.doi.org/10.3390/pathogens11091018
_version_ 1784796583485767680
author Turaiche, Mirela
Feciche, Bogdan
Gluhovschi, Adrian
Bratosin, Felix
Bogdan, Iulia
Bota, Adrian Vasile
Grigoras, Mirela Loredana
Gurban, Camelia Vidita
Cerbu, Bianca
Toma, Ana-Olivia
Gurumurthy, Srivathsava
Wulandari, Prima Hapsari
Marincu, Iosif
author_facet Turaiche, Mirela
Feciche, Bogdan
Gluhovschi, Adrian
Bratosin, Felix
Bogdan, Iulia
Bota, Adrian Vasile
Grigoras, Mirela Loredana
Gurban, Camelia Vidita
Cerbu, Bianca
Toma, Ana-Olivia
Gurumurthy, Srivathsava
Wulandari, Prima Hapsari
Marincu, Iosif
author_sort Turaiche, Mirela
collection PubMed
description Measles is a highly infectious and sometimes deadly illness that is preventable with vaccination. The present research aims to analyze the most recent measles epidemic from Romania that occurred in a population with a falling desire to receive immunizations, by detailing the clinical picture and biological profile of hospitalized patients. A secondary goal of the present research is to identify characteristics that increase the likelihood of a longer hospitalization and the development of measles-related pneumonia. A retrospective cohort study was conducted to follow the course and effects of measles virus infection in adult hospitalized patients who were divided into two groups based on whether they had been in the hospital for more than 6 days or fewer than 6 days. A total of 114 adult patients with measles were eligible to participate in the trial if they had a positive measles-specific IgM antibody test resulting from the study. The average age in the short hospital stay group was 28.1 years, while the average age in the long hospital stay group was 31.9 years. There was a statistically significant difference in the number of Roma persons in the research groups, with 17.4 percent of them having a lengthy hospital stay compared to 5.9 percent in the group with a short hospital stay, according to the findings. It was observed that many patients had a long hospitalization associated with chronic lung disease (OR = 1.07), liver damage (OR = 1.66), Roma ethnicity (OR = 1.79), a long duration elapsed from the last MMR dose (OR = 2.02), elevated c-reactive protein (OR = 2.17), the presence of bilateral pulmonary condensations on X-ray (OR = 3.13), and elevated procalcitonin (OR = 3.49). The same significant independent risk factors were also associated with the development of pneumonia. It is of imperative need to address these risk factors in a patient with measles, moreover in association with an unknown status of vaccination. Vaccination awareness against measles must be pushed in Romania to determine a higher than 95% coverage. Significant efforts are still needed to ensure improved protection against measles epidemics within a specific region or population and, more importantly, in patients with significant risk factors for complications, as described in this study.
format Online
Article
Text
id pubmed-9505879
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95058792022-09-24 Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania Turaiche, Mirela Feciche, Bogdan Gluhovschi, Adrian Bratosin, Felix Bogdan, Iulia Bota, Adrian Vasile Grigoras, Mirela Loredana Gurban, Camelia Vidita Cerbu, Bianca Toma, Ana-Olivia Gurumurthy, Srivathsava Wulandari, Prima Hapsari Marincu, Iosif Pathogens Article Measles is a highly infectious and sometimes deadly illness that is preventable with vaccination. The present research aims to analyze the most recent measles epidemic from Romania that occurred in a population with a falling desire to receive immunizations, by detailing the clinical picture and biological profile of hospitalized patients. A secondary goal of the present research is to identify characteristics that increase the likelihood of a longer hospitalization and the development of measles-related pneumonia. A retrospective cohort study was conducted to follow the course and effects of measles virus infection in adult hospitalized patients who were divided into two groups based on whether they had been in the hospital for more than 6 days or fewer than 6 days. A total of 114 adult patients with measles were eligible to participate in the trial if they had a positive measles-specific IgM antibody test resulting from the study. The average age in the short hospital stay group was 28.1 years, while the average age in the long hospital stay group was 31.9 years. There was a statistically significant difference in the number of Roma persons in the research groups, with 17.4 percent of them having a lengthy hospital stay compared to 5.9 percent in the group with a short hospital stay, according to the findings. It was observed that many patients had a long hospitalization associated with chronic lung disease (OR = 1.07), liver damage (OR = 1.66), Roma ethnicity (OR = 1.79), a long duration elapsed from the last MMR dose (OR = 2.02), elevated c-reactive protein (OR = 2.17), the presence of bilateral pulmonary condensations on X-ray (OR = 3.13), and elevated procalcitonin (OR = 3.49). The same significant independent risk factors were also associated with the development of pneumonia. It is of imperative need to address these risk factors in a patient with measles, moreover in association with an unknown status of vaccination. Vaccination awareness against measles must be pushed in Romania to determine a higher than 95% coverage. Significant efforts are still needed to ensure improved protection against measles epidemics within a specific region or population and, more importantly, in patients with significant risk factors for complications, as described in this study. MDPI 2022-09-07 /pmc/articles/PMC9505879/ /pubmed/36145449 http://dx.doi.org/10.3390/pathogens11091018 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Turaiche, Mirela
Feciche, Bogdan
Gluhovschi, Adrian
Bratosin, Felix
Bogdan, Iulia
Bota, Adrian Vasile
Grigoras, Mirela Loredana
Gurban, Camelia Vidita
Cerbu, Bianca
Toma, Ana-Olivia
Gurumurthy, Srivathsava
Wulandari, Prima Hapsari
Marincu, Iosif
Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania
title Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania
title_full Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania
title_fullStr Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania
title_full_unstemmed Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania
title_short Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania
title_sort biological profile and clinical features as determinants for prolonged hospitalization in adult patients with measles: a monocentric study in western romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505879/
https://www.ncbi.nlm.nih.gov/pubmed/36145449
http://dx.doi.org/10.3390/pathogens11091018
work_keys_str_mv AT turaichemirela biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT fecichebogdan biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT gluhovschiadrian biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT bratosinfelix biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT bogdaniulia biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT botaadrianvasile biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT grigorasmirelaloredana biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT gurbancameliavidita biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT cerbubianca biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT tomaanaolivia biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT gurumurthysrivathsava biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT wulandariprimahapsari biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania
AT marincuiosif biologicalprofileandclinicalfeaturesasdeterminantsforprolongedhospitalizationinadultpatientswithmeaslesamonocentricstudyinwesternromania