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Experimental Phaeohyphomycosis of Curvularia lunata
Originally considered to be a plant pathogen, reports of phaeohyphomycosis due to Curvularia lunata (C. lunata) in animals and humans are increasing. However, studies on the pathogenesis, virulence, and epidemiology of C. lunata have rarely been discussed. In the present study, BALB/c mice were expe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505888/ https://www.ncbi.nlm.nih.gov/pubmed/36143037 http://dx.doi.org/10.3390/jcm11185393 |
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author | Al-Odaini, Najwa Pan, Kai-su Liao, Liu-wei Mo, Nan-fang Jiang, Zhi-wen Li, Tian-tian Li, Xiu-ying He, Xiao-juan Zheng, Dong-yan Cao, Cun-wei |
author_facet | Al-Odaini, Najwa Pan, Kai-su Liao, Liu-wei Mo, Nan-fang Jiang, Zhi-wen Li, Tian-tian Li, Xiu-ying He, Xiao-juan Zheng, Dong-yan Cao, Cun-wei |
author_sort | Al-Odaini, Najwa |
collection | PubMed |
description | Originally considered to be a plant pathogen, reports of phaeohyphomycosis due to Curvularia lunata (C. lunata) in animals and humans are increasing. However, studies on the pathogenesis, virulence, and epidemiology of C. lunata have rarely been discussed. In the present study, BALB/c mice were experimentally inoculated with C. lunata suspension by different routes and the course of infection was evaluated. In addition, the in vitro antifungal susceptibility of C. lunata against six commonly used antifungals was evaluated using the microdilution method. Inoculation resulted in skin lesions in animals inoculated intraperitonially and subcutaneously. Infection was confirmed by both mycological and histopathologic examination. C. lunata spores and hyphae were detected in the histopathologic sections stained with hexamine silver staining. In addition, voriconazole (VRC) demonstrated greater activity against C. lunata when compared to the other antifungals, whereas fluconazole (FLC) was the least active antifungal with a minimum inhibitory concentration (MIC) range of 8–16 μg/mL. Further studies are necessary to understand the pathogenicity of C. lunata and uncover the mystery of this fungus. |
format | Online Article Text |
id | pubmed-9505888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95058882022-09-24 Experimental Phaeohyphomycosis of Curvularia lunata Al-Odaini, Najwa Pan, Kai-su Liao, Liu-wei Mo, Nan-fang Jiang, Zhi-wen Li, Tian-tian Li, Xiu-ying He, Xiao-juan Zheng, Dong-yan Cao, Cun-wei J Clin Med Article Originally considered to be a plant pathogen, reports of phaeohyphomycosis due to Curvularia lunata (C. lunata) in animals and humans are increasing. However, studies on the pathogenesis, virulence, and epidemiology of C. lunata have rarely been discussed. In the present study, BALB/c mice were experimentally inoculated with C. lunata suspension by different routes and the course of infection was evaluated. In addition, the in vitro antifungal susceptibility of C. lunata against six commonly used antifungals was evaluated using the microdilution method. Inoculation resulted in skin lesions in animals inoculated intraperitonially and subcutaneously. Infection was confirmed by both mycological and histopathologic examination. C. lunata spores and hyphae were detected in the histopathologic sections stained with hexamine silver staining. In addition, voriconazole (VRC) demonstrated greater activity against C. lunata when compared to the other antifungals, whereas fluconazole (FLC) was the least active antifungal with a minimum inhibitory concentration (MIC) range of 8–16 μg/mL. Further studies are necessary to understand the pathogenicity of C. lunata and uncover the mystery of this fungus. MDPI 2022-09-14 /pmc/articles/PMC9505888/ /pubmed/36143037 http://dx.doi.org/10.3390/jcm11185393 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Al-Odaini, Najwa Pan, Kai-su Liao, Liu-wei Mo, Nan-fang Jiang, Zhi-wen Li, Tian-tian Li, Xiu-ying He, Xiao-juan Zheng, Dong-yan Cao, Cun-wei Experimental Phaeohyphomycosis of Curvularia lunata |
title | Experimental Phaeohyphomycosis of Curvularia lunata |
title_full | Experimental Phaeohyphomycosis of Curvularia lunata |
title_fullStr | Experimental Phaeohyphomycosis of Curvularia lunata |
title_full_unstemmed | Experimental Phaeohyphomycosis of Curvularia lunata |
title_short | Experimental Phaeohyphomycosis of Curvularia lunata |
title_sort | experimental phaeohyphomycosis of curvularia lunata |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505888/ https://www.ncbi.nlm.nih.gov/pubmed/36143037 http://dx.doi.org/10.3390/jcm11185393 |
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