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Experimental Phaeohyphomycosis of Curvularia lunata

Originally considered to be a plant pathogen, reports of phaeohyphomycosis due to Curvularia lunata (C. lunata) in animals and humans are increasing. However, studies on the pathogenesis, virulence, and epidemiology of C. lunata have rarely been discussed. In the present study, BALB/c mice were expe...

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Autores principales: Al-Odaini, Najwa, Pan, Kai-su, Liao, Liu-wei, Mo, Nan-fang, Jiang, Zhi-wen, Li, Tian-tian, Li, Xiu-ying, He, Xiao-juan, Zheng, Dong-yan, Cao, Cun-wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505888/
https://www.ncbi.nlm.nih.gov/pubmed/36143037
http://dx.doi.org/10.3390/jcm11185393
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author Al-Odaini, Najwa
Pan, Kai-su
Liao, Liu-wei
Mo, Nan-fang
Jiang, Zhi-wen
Li, Tian-tian
Li, Xiu-ying
He, Xiao-juan
Zheng, Dong-yan
Cao, Cun-wei
author_facet Al-Odaini, Najwa
Pan, Kai-su
Liao, Liu-wei
Mo, Nan-fang
Jiang, Zhi-wen
Li, Tian-tian
Li, Xiu-ying
He, Xiao-juan
Zheng, Dong-yan
Cao, Cun-wei
author_sort Al-Odaini, Najwa
collection PubMed
description Originally considered to be a plant pathogen, reports of phaeohyphomycosis due to Curvularia lunata (C. lunata) in animals and humans are increasing. However, studies on the pathogenesis, virulence, and epidemiology of C. lunata have rarely been discussed. In the present study, BALB/c mice were experimentally inoculated with C. lunata suspension by different routes and the course of infection was evaluated. In addition, the in vitro antifungal susceptibility of C. lunata against six commonly used antifungals was evaluated using the microdilution method. Inoculation resulted in skin lesions in animals inoculated intraperitonially and subcutaneously. Infection was confirmed by both mycological and histopathologic examination. C. lunata spores and hyphae were detected in the histopathologic sections stained with hexamine silver staining. In addition, voriconazole (VRC) demonstrated greater activity against C. lunata when compared to the other antifungals, whereas fluconazole (FLC) was the least active antifungal with a minimum inhibitory concentration (MIC) range of 8–16 μg/mL. Further studies are necessary to understand the pathogenicity of C. lunata and uncover the mystery of this fungus.
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spelling pubmed-95058882022-09-24 Experimental Phaeohyphomycosis of Curvularia lunata Al-Odaini, Najwa Pan, Kai-su Liao, Liu-wei Mo, Nan-fang Jiang, Zhi-wen Li, Tian-tian Li, Xiu-ying He, Xiao-juan Zheng, Dong-yan Cao, Cun-wei J Clin Med Article Originally considered to be a plant pathogen, reports of phaeohyphomycosis due to Curvularia lunata (C. lunata) in animals and humans are increasing. However, studies on the pathogenesis, virulence, and epidemiology of C. lunata have rarely been discussed. In the present study, BALB/c mice were experimentally inoculated with C. lunata suspension by different routes and the course of infection was evaluated. In addition, the in vitro antifungal susceptibility of C. lunata against six commonly used antifungals was evaluated using the microdilution method. Inoculation resulted in skin lesions in animals inoculated intraperitonially and subcutaneously. Infection was confirmed by both mycological and histopathologic examination. C. lunata spores and hyphae were detected in the histopathologic sections stained with hexamine silver staining. In addition, voriconazole (VRC) demonstrated greater activity against C. lunata when compared to the other antifungals, whereas fluconazole (FLC) was the least active antifungal with a minimum inhibitory concentration (MIC) range of 8–16 μg/mL. Further studies are necessary to understand the pathogenicity of C. lunata and uncover the mystery of this fungus. MDPI 2022-09-14 /pmc/articles/PMC9505888/ /pubmed/36143037 http://dx.doi.org/10.3390/jcm11185393 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al-Odaini, Najwa
Pan, Kai-su
Liao, Liu-wei
Mo, Nan-fang
Jiang, Zhi-wen
Li, Tian-tian
Li, Xiu-ying
He, Xiao-juan
Zheng, Dong-yan
Cao, Cun-wei
Experimental Phaeohyphomycosis of Curvularia lunata
title Experimental Phaeohyphomycosis of Curvularia lunata
title_full Experimental Phaeohyphomycosis of Curvularia lunata
title_fullStr Experimental Phaeohyphomycosis of Curvularia lunata
title_full_unstemmed Experimental Phaeohyphomycosis of Curvularia lunata
title_short Experimental Phaeohyphomycosis of Curvularia lunata
title_sort experimental phaeohyphomycosis of curvularia lunata
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505888/
https://www.ncbi.nlm.nih.gov/pubmed/36143037
http://dx.doi.org/10.3390/jcm11185393
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